The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Risk of hip fracture in patients with a history of schizophrenia
Open accessAbstract
Background: There is evidence of an association between decreased bone mineral density schizophrenia, and prolactin-raising antipsychotic medication. However, it is not known whether this is clinically significant. Aims: To investigate whether patients with a history of schizophrenia are at increased risk of hip fracture. Method: In a case-control study, we compared cases of ‘hip fracture’ on the General Practice Research Database (n=16 341) with matched controls (n=29 889). Results: Hip fracture was associated with schizophrenia (OR=1.73; 95% CI 1.32-2.28), and prolactin-raising antipsychotics (OR=2.6; 95% CI 2.432.78), in the univariate analysis. In the multivariate analysis, prolactin-raising antipsychotics were independently associated with hip fracture but schizophrenia was not. A significant interaction between gender and antipsychotics was found in the association with hip fracture (P=0.042); OR=2.12 (95% C11.73-2.59)for men, OR=l.93 (95% C11.78-2.10) for women. Conclusions: The association between prolactin-raising antipsychotic medication and hip fracture may have serious implications for public health. Mental health service patients may require preventive measures including dietary and lifestyle advice.
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“Other studies (506-510) have found significant increases (OR=1.2-2.6) in the risk of fractures associated with AP.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [506]
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“Other studies (506-510) have found significant increases (OR=1.”
BackgroundGoodwin, G., Haddad, P. M., Ferrier, I. N., Aronson, J., Barnes, T., Cipriani, A., Coghill, D., Fazel, S., Geddes, J. R., Grunze, H., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116636545 · Cited by 1,343
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“One case-control study investigated whether potential treatment-emergent decreases in bone mineral density could confer an increased risk of hip fractures in patients with a history of schizophrenia [87].”
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Metadata
- Authors
- Howard, L., Kirkwood, G., & Leese, M.
- Affiliations
- King's College London (GB)
- Corresponding author
- Howard, Louise
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2007-02
- Volume
- 190
- Issue
- 2
- Pages
- 129-134
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2166620991
- Cited by
- 158
- References
- 29
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 5 · 2014: 11 · 2013: 15 · 2012: 15
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- hip fracture, schizophrenia, bone mineral density, fracture risk, sex differences, fracture prevention, psychiatric patients
- MeSH terms
- Accidental Falls, Female, Hip Fractures, Humans, Male, Prolactin, Risk Factors, Schizophrenia, Antipsychotic Agents, Bone Density, Case-Control Studies
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