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Treatment with antipsychotics and the risk of diabetes in clinical practice
Open accessAbstract
Background: Treatment with antipsychotics seems to increase the risk of developing diabetes but the association is poorly characterised in clinical practice. Aims: To investigate and characterise the incidence of diabetes for people treated with antipsychotic medication in clinical practice. Method: The study used the linkage of registers of all prescribed antipsychotics, antidiabetics and diagnoses of diabetes in Denmark during a period from 1996 to 2005 and identified all people treated with antipsychotics in Denmark and a random sample of about 30% of the total Danish population. Results: In total, 345 937 patients who purchased antipsychotics and 1 426 488 unexposed individuals were included in the study. Among the total population, 50 379 individuals subsequently developed incident diabetes. Compared with unexposed individuals, treatment with first- (rate ratio, RR = 1.53, 95% CI 1.49–1.56) as well as second-generation (RR = 1.32, 95% CI 1.22–1.42) antipsychotics was associated with increased risk of subsequent incident diabetes. The rate of incident diabetes varied substantially between individual second-generation antipsychotic drugs (olanzapine, risperidone clozapine compared with unexposed individuals: low to moderate rate ratio between 1.17 and 1.57; ziprasidone and sertindol: two or more times increased rate ratio; amisulpride, quetiapine and aripiprazole: no significantly increased rate ratio). For both first- and second-generation antipsychotics, the incidence of diabetes increased with the number of prescriptions. Additionally, the incidence of diabetes increased with the number of combined antipsychotic drugs. Conclusions: In clinical practice, treatment with first- and second-generation antipsychotics is associated with an increased risk of developing incident diabetes with large differences between individual drugs. The risk increases with the duration of treatment and with polypharmacy of antipsychotic drugs.
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“Variations in the risk for glucose abnormalities are evident in the literature, with the highest risk being associated with clozapine, olanzapine and quetiapine in carefully designed studies 25,34,35 .”
From Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis (2016) · cites this paper as [35]
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“antipsychotics with lower cardiometabolic risk profiles in short-term studies are often prescribed for higher risk patients in clinical care, which may lead to a not reduced or even increased cardiometabolic risk in naturalistic settings (42).”
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Cites
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892
The Danish National Hospital Register. A valuable source of data for modern health sciences.
Andersen, T. F., Madsen, M., Jørgensen, J. O. L., Mellemkjoer, L., & Olsen, J. H. (1999) · PubMed · Cited by 2,026
Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes
Boehm, G., Racoosin, J. A., LAUGHREN, T. P., & Katz, R. G. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.2088-a · Cited by 1,204
The Danish Psychiatric Central Register.
Munk‐Jørgensen, P., & Mortensen, P. B. (1997) · PubMed · Cited by 698
Prevalence and Correlates of Diabetes in National Schizophrenia Samples
Dixon, L. B., Weiden, P. J., Delahanty, J. C., Goldberg, R., Postrado, L. T., Lucksted, A. A., & Lehman, A. F. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033504 · Cited by 570
The Danish registers of causes of death.
Juel, K., & Helweg‐Larsen, K. (1999) · PubMed · Cited by 410
Diabetes mellitus in schizophrenic patients
Mukherjee, S., Decina, P., Bocola, V., Saraceni, F., & Scapicchio, P. L. (1996) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(96)90054-1 · Cited by 368
Regenold, W. T. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00456-6 · Cited by 290
Smith, M. J., Hopkins, D., Peveler, R., Holt, R. I. G., Woodward, M., & Ismail, K. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.037184 · Cited by 274
Gianfrancesco, F. D., Grogg, A. L., Mahmoud, R. A., Wang, R., & Nasrallah, H. A. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1010 · Cited by 238
Incidence of Newly Diagnosed Diabetes Attributable to Atypical Antipsychotic Medications
LESLIE, D. L., & Rosenheck, R. A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.9.1709 · Cited by 214
Jin, H., Meyer, J. M., & Jeste, D. V. (2002) · Annals of Clinical Psychiatry · doi:10.1023/a:1015228112495 · Cited by 213
Jin, H., Meyer, J. M., & Jeste, D. V. (2002) · Annals of Clinical Psychiatry · doi:10.3109/10401230209147399 · Cited by 203
A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States
Buse, J. B. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00588-7 · Cited by 176
The accelerating epidemic of childhood diabetes
Dabelea, D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60874-6 · Cited by 163
Spitzer, R. L. (1975) · American Journal of Psychiatry · doi:10.1176/ajp.132.8.881 · Cited by 160
Berger, B., Stenström, G., & Sundkvist, G. (1999) · Diabetes Care · doi:10.2337/diacare.22.5.773 · Cited by 137
The Atypical Antipsychotic Therapy and Metabolic Issues National Survey
Newcomer, J. W., Nasrallah, H. A., & Loebel, A. D. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000142281.85207.d5 · Cited by 133
Who Are the New Users of Antipsychotic Medications?
Domino, M. E., & Swartz, M. S. (2008) · Psychiatric Services · doi:10.1176/appi.ps.59.5.507 · Cited by 118
Yood, M. U., DeLorenze, G. N., Quesenberry, C. P., Oliveria, S. A., Tsai, A., Willey, V. J., McQuade, R. D., Newcomer, J. W., & L'Italien, G. J. (2009) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1781 · Cited by 106
Saddichha, S., Manjunatha, N., Ameen, S., & Akhtar, S. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01158.x · Cited by 86
Special Section on Implications of CATIE: Who Are the New Users of Antipsychotic Medications?
Domino, M. E., & Swartz, M. S. (2008) · Psychiatric Services · doi:10.1176/ps.2008.59.5.507 · Cited by 79
Ramaswamy, K., Masand, P. S., & Nasrallah, H. A. (2006) · Annals of Clinical Psychiatry · doi:10.1080/10401230600801234 · Cited by 77
Gianfrancesco, F. D., Grogg, A. L., Mahmoud, R. A., Wang, R., & Meletiche, D. M. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)80073-5 · Cited by 63
New cases of diabetes mellitus in England and Wales, 1994–1998: Database study
Ryan, R. P., Newnham, A., Khunti, K. K., & Majeed, A. (2005) · Public Health · doi:10.1016/j.puhe.2005.03.011 · Cited by 21
[The prevalence of diabetes in Denmark. Development of a method for a registry-based assessment].
Drivsholm, T., Frederiksen, K., Olivarius, N. D. F., Ødegaard, B., & Kristensen, J. K. (2003) · PubMed · Cited by 14
Age-Specific Incidence and Duration of Known Diabetes: The Cremona Study
Garancini, M. P., Gobbi, C., Errera, A., Sergi, A., & Gallus, G. (1996) · Diabetes Care · doi:10.2337/diacare.19.11.1279 · Cited by 12
Research works printed but not linked: 6
- Kristensen, 2000, Identification of the Type 2 Diabetes Population in a Danish County and Evaluation of the Performed Care in a Five-Year Period
- 2009, National Diabetes Surveillance System
- Malig, 1996, The Civil Registration System in Denmark. Technical Paper No 66
- 2002, Medicinal Product Statistics
- 1993, International Statistical Classification of Diseases and Health Related Problems, 10th revision [Danish version]
- 2003, ATC Index with DDDs
Cited by
Sorted by citations
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488
Vancampfort, D., Stubbs, B., Mitchell, A. J., De Hert, M., Wampers, M., Ward, P. B., Rosenbaum, S., & Correll, C. U. (2015) · World Psychiatry · doi:10.1002/wps.20252 · Cited by 1,271
Metabolic and cardiovascular adverse effects associated with antipsychotic drugs.
De Hert, M., Detraux, J., van Winkel, R., Yu, W., & Correll, C. U. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.156 · Cited by 1,145
Vancampfort, D., Correll, C. U., Galling, B., Probst, M., De Hert, M., Ward, P. B., Rosenbaum, S., Gaughran, F., Lally, J., & Stubbs, B. (2016) · World Psychiatry · doi:10.1002/wps.20309 · Cited by 659
Barnes, T. R. E., Drake, R., Paton, C., Cooper, S. J., Deakin, J. F. W., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I. R., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 615
Metadata
- Authors
- Kessing, L. V., Thomsen, A. F., Mogensen, U. B., & Andersen, P. K.
- Affiliations
- Copenhagen University Hospital (DK)
- University of Copenhagen (DK)
- Corresponding author
- Kessing, Lars Vedel
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2010-10
- Volume
- 197
- Issue
- 4
- Pages
- 266-271
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2117234502
- Cited by
- 152
- References
- 26
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 12 · 2018: 17 · 2017: 8 · 2016: 10 · 2015: 13 · 2014: 11 · 2013: 8 · 2012: 18
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- antipsychotic drugs, diabetes mellitus, new-onset diabetes, atypical antipsychotics, typical antipsychotics, olanzapine, risperidone, clozapine, ziprasidone, sertindole, amisulpride, quetiapine, aripiprazole, polypharmacy, treatment duration, drug safety
- MeSH terms
- Adult, Aged, Blood Glucose, Denmark, Diabetes Mellitus, Epidemiologic Methods, Female, Humans, Hypoglycemic Agents, Male, Middle Aged, Drug Prescriptions, Antipsychotic Agents, Sex Distribution, Pharmacoepidemiology, Polypharmacy, Young Adult
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