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Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies

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Lally, John, Ajnakina, Olesya, Stubbs, Brendon, Cullinane, Michael, Murphy, Kieran C., Gaughran, Fiona, Murray, Robin M.·2017·British Journal of Psychiatry

DOI 10.1192/bjp.bp.117.201475

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Abstract

Background: Remission and recovery rates for people with first-episode psychosis (FEP) remain uncertain. Aims: To assess pooled prevalence rates of remission and recovery in FEP and to investigate potential moderators. Method: We conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission and recovery in FEP in longitudinal studies with more than 1 year of follow-up data, and conducted meta-regression analyses to investigate potential moderators. Results: Seventy-nine studies were included representing 19072 patients with FEP. The pooled rate of remission among 12301 individuals with FEP was 58% (60 studies, mean follow-up 5.5 years). Higher remission rates were moderated by studies from more recent years. The pooled prevalence of recovery among 9642 individuals with FEP was 38% (35 studies, mean follow-up 7.2 years). Recovery rates were higher in North America than in other regions. Conclusions: Remission and recovery rates in FEP may be more favourable than previously thought. We observed stability of recovery rates after the first 2 years, suggesting that a progressive deteriorating course of illness is not typical. Although remission rates have improved over time recovery rates have not, raising questions about the effectiveness of services in achieving improved recovery.

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Authors: Lally, J., Ajnakina, O., Stubbs, B., Cullinane, M., Murphy, K. C., Gaughran, F., & Murray, R. M.
Affiliations: University College Dublin (IE)
Corresponding author: Lally, John
ORCID: Lally, John
Ajnakina, Olesya
Stubbs, Brendon
Murphy, Kieran C.
Gaughran, Fiona
Murray, Robin M.
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2017-12
Volume: 211
Issue: 6
Pages: 350-358
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.117.201475
OpenAlex: W2761844088
Cited by: 335
References: 107
Citations by year: 2026: 27 · 2025: 37 · 2024: 41 · 2023: 39 · 2022: 37 · 2021: 51 · 2020: 36 · 2019: 39 · 2018: 26 · 2017: 2
FWCI: 4.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 32 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion, other-oa)
Funders: Eli Lilly and Company
Sunovion
National Institute for Health and Care Research (NF-SI-0512-10110, RP-PG-0606-1049)
H. Lundbeck A/S
Medical Research Council (MR/K004867/1, MR/K013807/1)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Health Sciences › Health Professions › General Health Professions › Mental Health and Patient Involvement
Keywords: first-episode psychosis, remission, recovery, long-term outcomes, prevalence rates, clinical course
MeSH terms: Adult, Humans, Psychotic Disorders, Outcome Assessment, Health Care

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Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies

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