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Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies
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Background: Remission and recovery rates for people with first-episode psychosis (FEP) remain uncertain. Aims: To assess pooled prevalence rates of remission and recovery in FEP and to investigate potential moderators. Method: We conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission and recovery in FEP in longitudinal studies with more than 1 year of follow-up data, and conducted meta-regression analyses to investigate potential moderators. Results: Seventy-nine studies were included representing 19072 patients with FEP. The pooled rate of remission among 12301 individuals with FEP was 58% (60 studies, mean follow-up 5.5 years). Higher remission rates were moderated by studies from more recent years. The pooled prevalence of recovery among 9642 individuals with FEP was 38% (35 studies, mean follow-up 7.2 years). Recovery rates were higher in North America than in other regions. Conclusions: Remission and recovery rates in FEP may be more favourable than previously thought. We observed stability of recovery rates after the first 2 years, suggesting that a progressive deteriorating course of illness is not typical. Although remission rates have improved over time recovery rates have not, raising questions about the effectiveness of services in achieving improved recovery.
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Metadata
- Authors
- Lally, J., Ajnakina, O., Stubbs, B., Cullinane, M., Murphy, K. C., Gaughran, F., & Murray, R. M.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Lally, John
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2017-12
- Volume
- 211
- Issue
- 6
- Pages
- 350-358
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2761844088
- Cited by
- 335
- References
- 107
- Citations by year
- 2026: 27 · 2025: 37 · 2024: 41 · 2023: 39 · 2022: 37 · 2021: 51 · 2020: 36 · 2019: 39 · 2018: 26 · 2017: 2
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- Eli Lilly and Company
- Sunovion
- National Institute for Health and Care Research (NF-SI-0512-10110, RP-PG-0606-1049)
- H. Lundbeck A/S
- Medical Research Council (MR/K004867/1, MR/K013807/1)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Health Professions › General Health Professions › Mental Health and Patient Involvement
- Keywords
- first-episode psychosis, remission, recovery, long-term outcomes, prevalence rates, clinical course
- MeSH terms
- Adult, Humans, Psychotic Disorders, Outcome Assessment, Health Care
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