Ketamine: stimulating antidepressant treatment?
Open accessAbstract
Summary: The appeal of ketamine – in promptly ameliorating depressive symptoms even in those with non-response – has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives – derived from evidence and clinical experience – and to consider strategies for future investigations.
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Four further patients in esketamine arms had non-fatal motor vehicle accidents.
“and 4 further patients on esketamine arms had non-fatal motor vehicle accidents.25”
From Are we repeating mistakes of the past? A review of the evidence for esketamine (2021) · cites this paper as [25]
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References 42 · Cited by 29
- Authors
- Malhi, G. S., Byrow, Y., Cassidy, F., Cipriani, A., Demyttenaere, K., Frye, M. A., Gitlin, M., Kennedy, S. H., Ketter, T. A., Lam, R. W., McShane, R., Mitchell, A. J., Ostacher, M. J., Rizvi, S. J., Thase, M. E., & Tohen, M.
- Affiliations
- The University of Sydney (AU)
- Royal North Shore Hospital (AU)
- Duke University (US)
- Oxford Health NHS Foundation Trust (GB)
- KU Leuven (BE)
- Mayo Clinic (US)
- University of California, Los Angeles (US)
- St. Michael's Hospital (CA)
- Stanford Medicine (US)
- University of British Columbia (CA)
- University of Leicester (GB)
- VA Palo Alto Health Care System (US)
- Philadelphia VA Medical Center (US)
- University of New Mexico (US)
- Corresponding author
- Malhi, Gin S.
- ORCID
- Venue
- BJPsych Open
- Publisher
- Royal College of Psychiatrists
- Published
- 2016-05
- Volume
- 2
- Issue
- 3
- Pages
- e5-e9
- ISSN
- 2056-4724 (ISSN-L)
- PMC
- PMC4995167
- OpenAlex
- W2385546112
- Cited by
- 29
- References
- 42
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 2
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BJPsych Open (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Sunovion
- ACADIA Pharmaceuticals
- National Institute for Health and Care Research (PB-PG-0408-16030)
- Oxford Health NHS Foundation Trust
- Janssen Pharmaceuticals
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- ketamine, depression, antidepressant treatment, treatment-resistant depression, off-label drug use, long-term administration, mood disorders, expert consensus
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