Antipsychotic-Induced Increase in Lipid Biosynthesis: Activation through Inhibition?
Open accessAbstract
Antipsychotic drugs have become indispensable in the treatment of schizophrenia since the introduction of first-generation antipsychotics (FGA; e.g., chlorpromazine and haloperidol) in the 1950s. Unfortunately, several of the commonly used drugs, particularly the second-generation antipsychotics (SGA) clozapine and olanzapine, induce metabolic disturbances, such as obesity, hypertriglyceridemia, glucose dysregulation, and in some studies, elevated serum cholesterol levels (1, 2). These adverse effects represent major challenges in the treatment of psychotic disorders, as they reduce compliance and contribute to increased cardiovascular mortality among patients (3).
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Antipsychotic drugs induce the transcriptional activation of cholesterol and FA biosynthesis genes under the control of the transcription factors SREBP1 and SREBP2.
“Antipsychotic drugs induce the transcriptional activation of cholesterol and FA biosynthesis genes under the control of the transcription factors SREBP1 and SREBP2 [129].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [129]
Treatment with antipsychotic drugs is associated with metabolic disturbances, including obesity, hypertriglyceridemia, and glucose dysregulation.
“Treatment with antipsychotic drugs has been associated with metabolic disturbances, and side effects of these drugs, such as obesity, hypertriglyceridemia, and glucose dysregulation, have been linked to these processes [129].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [129]
Antipsychotic drugs inhibit cholesterol biosynthesis, affecting the same enzymes with different relative activity: ziprasidone > haloperidol > risperidone.
“Antipsychotic drugs induce the inhibition of cholesterol biosynthesis, affecting the same enzymes with a different relative activity: ziprasidone > haloperidol > risperidone [129].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [129]
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- Authors
- Skrede, S., Steen, V. M., & Fern⊘, J.
- Affiliations
- Haukeland University Hospital (NO)
- Corresponding author
- Fern⊘, Johan
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 54
- Issue
- 2
- Pages
- 307-309
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC3588860
- OpenAlex
- W2103609043
- Cited by
- 23
- References
- 24
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2013: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- antipsychotic drugs, lipogenesis, atypical antipsychotics, typical antipsychotics, clozapine, olanzapine, metabolic side effects, hypertriglyceridemia, obesity, hypercholesterolemia, glucose dysregulation, schizophrenia
- MeSH terms
- Cholesterol, Fatty Acids, Humans, Antipsychotic Agents
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