The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation
Open accessAbstract
In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state. Importantly, BAT content and activity decline in obese subjects, mainly as a result of the conversion of brown adipocytes to white-like unilocular cells. Here, we show that BAT "whitening " is induced by multiple factors, including high ambient temperature, leptin receptor deficiency, β-adrenergic signaling impairment, and lipase deficiency, each of which is capable of inducing macrophage infiltration, brown adipocyte death, and crown-like structure (CLS) formation. Brown-to-white conversion and increased CLS formation were most marked in BAT from adipose triglyceride lipase ( Atgl )-deficient mice, where, according to transmission electron microscopy, whitened brown adipocytes contained enlarged endoplasmic reticulum, cholesterol crystals, and some degenerating mitochondria, and were surrounded by an increased number of collagen fibrils. Gene expression analysis showed that BAT whitening in Atgl -deficient mice was associated to a strong inflammatory response and NLRP3 inflammasome activation. Altogether, the present findings suggest that converted enlarged brown adipocytes are highly prone to death, which, by promoting inflammation in whitened BAT, may contribute to the typical inflammatory state seen in obesity.
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Cites
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Obesity is associated with macrophage accumulation in adipose tissue
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Brown Adipose Tissue: Function and Physiological Significance
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Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
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Inflammation, metaflammation and immunometabolic disorders
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Self-citation
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Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
Morigny, P., Boucher, J., Arner, P., & Langin, D. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00471-8 · Cited by 527
Taru, V., Szabo, G., Mehal, W., & Reiberger, T. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.06.016 · Cited by 344
Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action
Mohajer, N., Du, C. Y., Checkcinco, C., & Blumberg, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.780888 · Cited by 72
Worsch, S., Heikenwalder, M., Hauner, H., & Bader, B. L. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0291-x · Cited by 34
Metadata
- Authors
- Kotzbeck, P., Giordano, A., Mondini, E., Murano, I., Severi, I., Venema, W., Cecchini, M. P., Kershaw, E. E., Barbatelli, G., Haemmerle, G., Zechner, R., & Cinti, S.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2018
- Volume
- 59
- Issue
- 5
- Pages
- 784-794
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2795070658
- Cited by
- 293
- References
- 58
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kotzbeck, P., Giordano, A., Mondini, E., Murano, I., Severi, I., Venema, W., Cecchini, M. P., Kershaw, E. E., Barbatelli, G., Haemmerle, G., Zechner, R., & Cinti, S. (2018). Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation. Journal of Lipid Research. https://doi.org/10.1194/jlr.m079665
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