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Hepatocyte sortilin 1 knockout and treatment with a sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice
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Hepatocyte sortilin modulates very low density lipoprotein (VLDL) secretion.
“In addition to facilitating PCSK9 secretion, hepatocyte sortilin has been shown to modulate very low density lipoprotein (VLDL) secretion;66–70”
From EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis (2025) · cites this paper as [66]
Hepatocyte-specific sortilin knockout mice have decreased plasma PCSK9 and increased liver LDLR.
“Similar to our hepatocyte EHBP1-silenced mice, hepatocyte-specific sortilin knockout mice have decreased plasma PCSK9 and increased liver LDLR.48,66”
From EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis (2025) · cites this paper as [66]
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From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
Musunuru, K., Strong, A., Frank-Kamenetsky, M., Lee, N. E., Ahfeldt, T., Sachs, K. V., Li, X., Li, H., Kuperwasser, N., Ruda, V. M., et al. (2010) · Nature · doi:10.1038/nature09266 · Cited by 1,140
Myocardial Infarction Genetics Consortium (2009) · Nature Genetics · doi:10.1038/ng.327 · Cited by 1,088
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH
Caballero, F., Fernández, A., De Lacy, A. M., Fernández-Checa, J. C., Caballería, J., & García-Ruiz, C. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.016 · Cited by 368
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
Strong, A., Ding, Q., Edmondson, A. C., Millar, J. S., Sachs, K. V., Li, X., Kumaravel, A., Wang, M. Y., Ai, D., Guo, L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63563 · Cited by 222
Macrophage Sortilin Promotes LDL Uptake, Foam Cell Formation, and Atherosclerosis
Patel, K. M., Strong, A., Tohyama, J., Jin, X., Morales, C. R., Billheimer, J., Millar, J., Kruth, H., & Rader, D. J. (2015) · Circulation Research · doi:10.1161/circresaha.116.305811 · Cited by 194
The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion
Gustafsen, C., Kjolby, M., Nyegaard, M., Mattheisen, M., Lundhede, J., Buttenschøn, H., Mors, O., Bentzon, J. F., Madsen, P., Nykjaer, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.006 · Cited by 170
Butkinaree, C., Canuel, M., Essalmani, R., Poirier, S., Benjannet, S., Asselin, M.-C., Roubtsova, A., Hamelin, J., Marcinkiewicz, J., Chamberland, A., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.647180 · Cited by 53
Flagged first, then by citations
Research works printed but not linked: 33
- Anstee, 2013, Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis, Nat. Rev. Gastroenterol. Hepatol., 10, 330, 10.1038/nrgastro.2013.41 · DOI · Paper page
- Lonardo, 2013, Cardiovascular and systemic risk in nonalcoholic fatty liver disease - atherosclerosis as a major player in the natural course of NAFLD, Curr. Pharm. Des., 19, 5177, 10.2174/1381612811319290003 · DOI
- Puri, 2007, A lipidomic analysis of nonalcoholic fatty liver disease, Hepatology., 46, 1081, 10.1002/hep.21763 · DOI · Paper page
- Marí, 2006, Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis, Cell Metab., 4, 185, 10.1016/j.cmet.2006.07.006 · DOI
- Matsuzawa, 2007, Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet, Hepatology., 46, 1392, 10.1002/hep.21874 · DOI
- Wouters, 2008, Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis, Hepatology., 48, 474, 10.1002/hep.22363 · DOI
- Van Rooyen, 2011, Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis, Gastroenterology., 141, 1393, 10.1053/j.gastro.2011.06.040 · DOI
- Leroux, 2012, Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis, J. Hepatol., 57, 141, 10.1016/j.jhep.2012.02.028 · DOI · Paper page
- Arguello, 2015, Recent insights on the role of cholesterol in non-alcoholic fatty liver disease, Biochim. Biophys. Acta., 1852, 1765, 10.1016/j.bbadis.2015.05.015 · DOI
- Walenbergh, 2013, Non-alcoholic steatohepatitis: the role of oxidized low-density lipoproteins, J. Hepatol., 58, 801, 10.1016/j.jhep.2012.11.014 · DOI
- Hermey, 2009, The Vps10p-domain receptor family, Cell. Mol. Life Sci., 66, 2677, 10.1007/s00018-009-0043-1 · DOI
- Nykjaer, 2012, Sortilin: a receptor to regulate neuronal viability and function, Trends Neurosci., 35, 261, 10.1016/j.tins.2012.01.003 · DOI
- Lin, 1997, Sortilin is a major protein component of Glut4-containing vesicles, J. Biol. Chem., 272, 24145, 10.1074/jbc.272.39.24145 · DOI
- Shi, 2005, Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3–L1 adipocytes, Dev. Cell., 9, 99, 10.1016/j.devcel.2005.04.004 · DOI
- Tsuchiya, 2010, Palmitate-induced down-regulation of sortilin and impaired GLUT4 trafficking in C2C12 myotubes, J. Biol. Chem., 285, 34371, 10.1074/jbc.M110.128520 · DOI
- Kathiresan, 2008, Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans, Nat. Genet., 40, 189, 10.1038/ng.75 · DOI · Paper page
- Kjolby, 2010, Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export, Cell Metab., 12, 213, 10.1016/j.cmet.2010.08.006 · DOI · Paper page
- Li, 2017, Sortilin 1 modulates hepatic cholesterol lipotoxicity in mice via functional interaction with liver carboxylesterase 1, J. Biol. Chem., 292, 146, 10.1074/jbc.M116.762005 · DOI
- Mortensen, 2014, Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis, J. Clin. Invest., 124, 5317, 10.1172/JCI76002 · DOI
- Goettsch, 2016, Sortilin mediates vascular calcification via its recruitment into extracellular vesicles, J. Clin. Invest., 126, 1323, 10.1172/JCI80851 · DOI
- Strong, 2014, Sortilin and lipoprotein metabolism: making sense out of complexity, Curr. Opin. Lipidol., 25, 350, 10.1097/MOL.0000000000000110 · DOI
- Goettsch, 2018, Sortilin and its multiple roles in cardiovascular and metabolic diseases, Arterioscler. Thromb. Vasc. Biol., 38, 19, 10.1161/ATVBAHA.117.310292 · DOI
- Bachmanov, 2002, Food intake, water intake, and drinking spout side preference of 28 mouse strains, Behav. Genet., 32, 435, 10.1023/A:1020884312053 · DOI
- Li, 2018, Sortilin 1 loss-of-function protects against cholestatic liver injury by attenuating hepatic bile acid accumulation in bile duct ligated mice, Toxicol. Sci., 161, 34, 10.1093/toxsci/kfx078 · DOI
- Li, 2015, Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice, J. Biol. Chem., 290, 11526, 10.1074/jbc.M115.641225 · DOI
- Bi, 2013, Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice, J. Lipid Res., 54, 2754, 10.1194/jlr.M039347 · DOI
- Li, 2017, Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes, Biochim. Biophys. Acta Mol. Basis Dis., 1863, 2924, 10.1016/j.bbadis.2017.08.012 · DOI
- Feingold, 1996, Endotoxin, TNF, and IL-1 decrease cholesterol 7 alpha-hydroxylase mRNA levels and activity, J. Lipid Res., 37, 223, 10.1016/S0022-2275(20)37610-0 · DOI
- Miyake, 2000, Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase, J. Biol. Chem., 275, 21805, 10.1074/jbc.C000275200 · DOI
- Li, 2006, Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells, Hepatology., 43, 1202, 10.1002/hep.21183 · DOI
- Schrøder, 2014, The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin, Bioorg. Med. Chem. Lett., 24, 177, 10.1016/j.bmcl.2013.11.046 · DOI
- Herda, 2012, The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-gamma and granzyme A in T cells, Immunity., 37, 854, 10.1016/j.immuni.2012.07.012 · DOI
- Peterson, 2018, Macrophage-targeted therapeutics for metabolic disease, Trends Pharmacol. Sci., 39, 536, 10.1016/j.tips.2018.03.001 · DOI
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Sorted by citations
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis
Ma, F., Longo, M., Meroni, M., Bhattacharya, D., Paolini, E., Mughal, S., Hussain, S., Anand, S. K., Gupta, N., Zhu, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.01.020 · Cited by 29
Metadata
- Authors
- Chen, C., Li, J., Matye, D. J., Wang, Y., & Li, T.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 60
- Issue
- 3
- Pages
- 539-549
- ISSN
- 0022-2275
- Cited by
- 37
- References
- 7
- Language
- en
- Funders
- National Institutes of Health (1R01DK102487-01)
- American Diabetes Association
- National Center for Research Resources (5P20RR021940-07)
- National Institute of General Medical Sciences (8 P20 GM103549-07)
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