Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†

Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works

Nonalcoholic Fatty Liver Disease

Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works

Steatohepatitis: A tale of two “hits”?

Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works

Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions

Brunt, E. M., Janney, C. G., Di Bisceglie, A. M., Neuschwander-Tetri, B. A., & Bacon, B. R. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01377.x · Cited by 3,907 · see citing works

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834 · see citing works

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604 · see citing works

Molecular mediators of hepatic steatosis and liver injury

Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772 · see citing works

Cellular cholesterol trafficking and compartmentalization

Ikonen, E. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2336 · Cited by 1,455 · see citing works

A lipidomic analysis of nonalcoholic fatty liver disease

Puri, P., Baillie, R. A., Wiest, M. M., Mirshahi, F., Choudhury, J., Cheung, O., Sargeant, C., Contos, M. J., & Sanyal, A. J. (2007) · Hepatology · doi:10.1002/hep.21763 · Cited by 1,338 · see citing works

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

Repa, J. J., Turley, S. D., Lobaccaro, J. A., Medina, J. C., Li, L., Lustig, K. D., Shan, B., Heyman, R. A., Dietschy, J. M., & Mangelsdorf, D. J. (2000) · Science · doi:10.1126/science.289.5484.1524 · Cited by 1,303 · see citing works

Role of cholesterol and lipid organization in disease

Maxfield, F. R., & Tabas, I. A. (2005) · Nature · doi:10.1038/nature04399 · Cited by 1,298 · see citing works

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

Postic, C., & Girard, J. R. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34275 · Cited by 1,200 · see citing works

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works

Cytokines in Alcoholic and Nonalcoholic Steatohepatitis

Tilg, H., & Diehl, A. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011163432007 · Cited by 935 · see citing works

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M., Rong, J. X., Kuriakose, G., Fisher, E. A. A., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb1035 · Cited by 886 · see citing works

The role of TNFα and TNF receptors in obesity and insulin resistance

Hotamisligil, G. S. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00490.x · Cited by 780 · see citing works

Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients

Crespo, J., Cayón, A., Fernández-Gil, P. L., Hernández‐Guerra, M., Mayorga, M., Domínguez‐Díez, A., Fernández-Escalante, J. C., & Pons‐Romero, F. (2001) · Hepatology · doi:10.1053/jhep.2001.29628 · Cited by 693 · see citing works

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

Marı́, M., Caballero, F. G., Colell, A., Morales, A., Caballería, J., Fernandez, A., Enrich, C., Fernández-Checa, J. C., & García‐Ruiz, C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.006 · Cited by 605 · see citing works

Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet

Matsuzawa, N., Takamura, T., Kurita, S., Misu, H., Ota, T., Ando, H., Yokoyama, M., Honda, M., Zen, Y., Nakanuma, Y., et al. (2007) · Hepatology · doi:10.1002/hep.21874 · Cited by 516 · see citing works

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

Monetti, M., Levin, M. C., Watt, M. J., Sajan, M. P., Marmor, S., Hubbard, B. K., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.005 · Cited by 511 · see citing works

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis†

Wouters, K., van Gorp, P. J., Bieghs, V., Gijbels, M. J., Duimel, H., Lütjohann, D., Kerksiek, A., van Kruchten, R., Maeda, N., Staels, B., et al. (2008) · Hepatology · doi:10.1002/hep.22363 · Cited by 477 · see citing works

Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice

Tomita, K., Tamiya, G., Ando, S., Ohsumi, K., Chiyo, T., Mizutani, A., Kitamura, N., Toda, K., Kaneko, T., Horie, Y., et al. (2005) · Gut · doi:10.1136/gut.2005.071118 · Cited by 439 · see citing works

Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients

Ribeiro, P. S., Cortez‐Pinto, H., Solá, S., Castro, R. E., Ramalho, R. M., Baptista, A., de Moura, M. C., Camilo, M., & Rodrigues, C. M. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40009.x · Cited by 392 · see citing works

Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to Its Sterol-Sensing Domain

Sever, N., Yang, T., Brown, M. S., Goldstein, J. L., & DeBose‐Boyd, R. A. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00822-5 · Cited by 372 · see citing works

Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial

Lewis, J. H., Mortensen, M. E., Zweig, S., Fusco, M. J., Medoff, J. R., & Belder, R. (2007) · Hepatology · doi:10.1002/hep.21848 · Cited by 305 · see citing works

Studies on the Biological Properties of Polyene Antibiotics

Norman, A. W., DEMEL, R. A., Kruyff, B. D., & Deenen, L. L. M. V. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45558-0 · Cited by 299 · see citing works

Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

Song, B., Javitt, N. B., & DeBose‐Boyd, R. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.001 · Cited by 283 · see citing works

Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma

Montero, J., Morales, A., Llacuna, L., Lluis, J. M., Terrones, O., Basáñez, G., Antonsson, B. E., Prìeto, J., García‐Ruiz, C., Colell, A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6161 · Cited by 276 · see citing works

Apoptosis in alcoholic and nonalcoholic steatohepatitis

Ariel, E. F. (2005) · Frontiers in bioscience · doi:10.2741/1765 · Cited by 203 · see citing works

Ursodeoxycholic Acid and Atorvastatin in the Treatment of Nonalcoholic Steatohepatitis

Kıyıcı, M., Gülten, M., Gurel, S., Nak, S. G., Dolar, E., Savcı, G., Adım, Ş. B., Yerci, Ö., & Memik, F. (2003) · Canadian Journal of Gastroenterology · doi:10.1155/2003/857869 · Cited by 199 · see citing works

Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study

Rallidis, L. S., Drakoulis, C., & Parasi, A. S. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.01.008 · Cited by 181 · see citing works

Animal models of steatohepatitis

Koteish, A. A., & Diehl, A. M. (2002) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2002.0332 · Cited by 175 · see citing works

Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein

Bose, M., Whittal, R. M., Miller, W. L., & Bose, H. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709221200 · Cited by 143 · see citing works

Mitochondrial cholesterol in health and disease.

García‐Ruiz, C., Marı́, M., Colell, A., Morales, A., Caballero, F. G., Montero, J., Terrones, O., Basáñez, G., & Fernández-Checa, J. C. (2009) · PubMed · doi:10.14670/hh-24.117 · Cited by 101 · see citing works

Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation

Marı́, M., Colell, A., Morales, A., Caballero, F., Moles, A., Fernández, A., Terrones, O., Basáñez, G., Antonsson, B. E., García‐Ruiz, C., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.073 · Cited by 96 · see citing works

Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells

Hall, E. A., Ren, S., Hylemon, P. B., Rodríguez‐Agudo, D., Redford, K. S., Marques, D., Kang, D., Gil, G., & Pandak, W. M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.01.004 · Cited by 65 · see citing works

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Mridha, A. R., Wree, A., Robertson, A. A. B., Yeh, M. M., Johnson, C. D., Van Rooyen, D. M., Haczeyni, F., Teoh, N. C.-H., Savard, C., Ioannou, G. N., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.01.022 · Cited by 1,110 · see citing works

Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease.

Lebeaupin, C., Vallée, D., Hazari, Y., Hetz, C., Chevet, É., & Bailly-maitre, B. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.06.008 · Cited by 835 · see citing works

Pathophysiology of diabetic dyslipidaemia: where are we?

Vergès, B. (2015) · Diabetologia · doi:10.1007/s00125-015-3525-8 · Cited by 708 · see citing works

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.003 · Cited by 678 · see citing works

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

Min, H., Kapoor, A., Fuchs, M. A., Mirshahi, F., Zhou, H., Maher, J. W., Kellum, J. M., Warnick, R., Contos, M. J., & Sanyal, A. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.004 · Cited by 653 · see citing works

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

Mota, M., Banini, B. A., Cazanave, S. C., & Sanyal, A. J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.014 · Cited by 570 · see citing works

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

Tsuchida, T., Lee, Y. A., Fujiwara, N., Ybanez, M., Allen, B., Martins, S., Fiel, M. I., Goossens, N., Chou, H.-I., Hoshida, Y., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.011 · Cited by 583 · see citing works

Glutathione and mitochondria

Ribas, V., García‐Ruiz, C., & Fernández-Checa, J. C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00151 · Cited by 572 · see citing works

Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

Duan, Y., Gong, K., Xu, S., Zhang, F., Meng, X., & Han, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01125-5 · Cited by 538 · see citing works

The Role of Cholesterol in the Pathogenesis of NASH

Ioannou, G. N. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.008 · Cited by 498 · see citing works

Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH

Pierantonelli, I., & Svegliati‐Baroni, G. (2018) · Transplantation · doi:10.1097/tp.0000000000002480 · Cited by 459 · see citing works

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis

Musso, G., Gambino, R., & Cassader, M. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.11.002 · Cited by 410 · see citing works

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

Alkhouri, N., Dixon, L. J., & Feldstein, A. E. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.09.32 · Cited by 400 · see citing works

NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

Farrell, G. C., Rooyen, D. M. V., Gan, L. T., & Chitturi, S. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.2.149 · Cited by 400 · see citing works

Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*

Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382 · see citing works

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., & Karin, M. (2018) · Cell · doi:10.1016/j.cell.2018.08.020 · Cited by 333 · see citing works

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

Rooyen, D. M. V., Larter, C. Z., Haigh, W. G., Yeh, M. M., Ioannou, G. N., Kuver, R., Lee, S. P., Teoh, N., & Farrell, G. C. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.040 · Cited by 345 · see citing works

Nonobese fatty liver disease

Kim, D., & Kim, W. R. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.08.028 · Cited by 341 · see citing works

Pathophysiology of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

Manne, V., Handa, P., & Kowdley, K. V. (2017) · Clinics in Liver Disease · doi:10.1016/j.cld.2017.08.007 · Cited by 336 · see citing works

Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

Pafili, K., & Roden, M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101122 · Cited by 330 · see citing works

Targeting the alternative bile acid synthetic pathway for metabolic diseases

Jia, W. P., Wei, M., Rajani, C., & Zheng, X. (2020) · Protein & Cell · doi:10.1007/s13238-020-00804-9 · Cited by 329 · see citing works

Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury

Roth, K., Yang, Z., Agarwal, M., Liu, W. J., Peng, Z., Long, Z., Birbeck, J. A., Westrick, J. A., Liu, W., & Petriello, M. C. (2021) · Environment International · doi:10.1016/j.envint.2021.106843 · Cited by 311 · see citing works

Recent insights on the role of cholesterol in non-alcoholic fatty liver disease

Argüello, G., Balboa, E., Arrese, M. A., & Zanlungo, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.05.015 · Cited by 306 · see citing works

Oxysterols in the pathogenesis of major chronic diseases

Poli, G., Biasi, F., & Leonarduzzi, G. (2013) · Redox Biology · doi:10.1016/j.redox.2012.12.001 · Cited by 304 · see citing works

Free radical biology for medicine: learning from nonalcoholic fatty liver disease

Serviddio, G., Bellanti, F., & Vendemiale, G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.174 · Cited by 269 · see citing works

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Cai, B., Dongiovanni, P., Corey, K. E., Wang, X., Shmarakov, I. O., Zheng, Z., Kasikara, C., Davra, V., Meroni, M., Chung, R. T., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.013 · Cited by 266 · see citing works

Cellular Mechanisms of Liver Fibrosis

Acharya, P., Chouhan, K., Weiskirchen, S., & Weiskirchen, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671640 · Cited by 252 · see citing works

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis

Caballero, F., Fernández, A., Matías, N., Martínez-Gili, L., Fucho, R., Elena, M., Caballería, J., Morales, A., Fernández-Checa, J. C., & García‐Ruiz, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.099333 · Cited by 238 · see citing works

Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver

Mihm, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103104 · Cited by 232 · see citing works

Role of Cholesterol‐Associated Steatohepatitis in the Development of NASH

Horn, C. L., Morales, A. L., Savard, C. E., Farrell, G. C., & Ioannou, G. N. (2021) · Hepatology Communications · doi:10.1002/hep4.1801 · Cited by 215 · see citing works

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.010 · Cited by 204 · see citing works

Molecular Pathogenesis of NASH

Caligiuri, A., Gentilini, A., & Marra, F. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091575 · Cited by 212 · see citing works

Non-alcoholic fatty liver disease: What the clinician needs to know

Machado, M. V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12956 · Cited by 209 · see citing works

Redox Control of Liver Function in Health and Disease

Marı́, M., Colell, A., Morales, A., von Montfort, C., García‐Ruiz, C., & Fernández-Checa, J. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2634 · Cited by 201 · see citing works

Mechanisms of Lipotoxicity in NAFLD and Clinical Implications

Ibrahim, S. H., Kohli, R., & Gores, G. J. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31822578db · Cited by 199 · see citing works

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

Gan, L. T., Rooyen, D. M. V., Koina, M. E., McCuskey, R. S., Teoh, N., & Farrell, G. C. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.024 · Cited by 199 · see citing works

Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease

García‐Ruiz, C., & Fernández-Checa, J. C. (2018) · Hepatology Communications · doi:10.1002/hep4.1271 · Cited by 197 · see citing works

Mitochondrial cholesterol: Metabolism and impact on redox biology and disease

Goicoechea, L., de la Rosa, L. C., Torres, S., García‐Ruiz, C., & Fernández-Checa, J. C. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102643 · Cited by 183 · see citing works

Pathogenesis of NASH: how metabolic complications of overnutrition favour lipotoxicity and pro-inflammatory fatty liver disease

Farrell, G. C., Haczeyni, F., & Chitturi, S. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-10-8684-7_3 · Cited by 178 · see citing works

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

Schierwagen, R., Maybüchen, L., Zimmer, S., Hittatiya, K., Bäck, C., Klein, S., Uschner, F., Reul, W., Boor, P., Nickenig, G., et al. (2015) · Scientific Reports · doi:10.1038/srep12931 · Cited by 176 · see citing works

New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis

Méndez‐Sánchez, N., Cruz-Ramón, V., Ramírez-Pérez, O., Hwang, J. P., Barranco-Fragoso, B., & Córdova‐Gallardo, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072034 · Cited by 174 · see citing works

Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective

Gusdon, A. M., Song, K., & Qu, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/637027 · Cited by 171 · see citing works

The mammalian START domain protein family in lipid transport in health and disease

Clark, B. J. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0313 · Cited by 163 · see citing works

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

Koh, E. H., Yoon, J. E., Ko, M. S., Leem, J., Yun, J.-Y., Hong, C. H., Cho, Y. K., Lee, S. E., Jang, J. E., Baek, J. Y., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-322509 · Cited by 156 · see citing works

Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity

Simonen, P. P., Kotronen, A., Hallikainen, M., Sevastianova, K., Makkonen, J., Hakkarainen, A., Lundbom, N. M. I., Miettinen, T. A., Gylling, H. K., & Yki‐Järvinen, H. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.037 · Cited by 153 · see citing works

Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities

Gambino, R., Musso, G., & Cassader, M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3058 · Cited by 146 · see citing works

miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR

Sun, C., Huang, F., LIU, X., Xiao, X., Yang, M., Hu, G. M., Liu, H., & Liao, L. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2076 · Cited by 147 · see citing works

Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease

Wang, J., He, W., Tsai, P.-J., Chen, P.-H., Ye, M., Guo, J., & Su, Z. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01210-0 · Cited by 147 · see citing works

Lipid Metabolism in Metabolic-Associated Steatotic Liver Disease (MASLD)

Syed‐Abdul, M. M. (2023) · Metabolites · doi:10.3390/metabo14010012 · Cited by 153 · see citing works

Lipidomics in non-alcoholic fatty liver disease

Kartsoli, S., Kostara, C. E., Tsimihodimos, V., Bairaktari, E. T., & Christodoulou, D. K. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i8.436 · Cited by 142 · see citing works

Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure

Torres, S., Baulies, A., Insausti-Urkia, N., Alarcón‐Vila, C., Fucho, R., Solsona‐Vilarrasa, E., Núñez, S., Robles, D., Ribas, V., Wakefield, L., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.04.023 · Cited by 138 · see citing works

Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis

Bellanti, F., Villani, R., Facciorusso, A., Vendemiale, G., & Serviddio, G. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.023 · Cited by 132 · see citing works

Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids

de Castro, G. S., & Calder, P. C. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.01.006 · Cited by 133 · see citing works

Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice

Ham, J. R., Lee, H.-I., Choi, R., Sim, M., Seo, K., & Lee, M. (2016) · Food & Function · doi:10.1039/c5fo01329a · Cited by 131 · see citing works

Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function

Martin, L. A., Kennedy, B. E., & Karten, B. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9592-6 · Cited by 128 · see citing works

The Role of Lipid and Lipoprotein Metabolism in Non‐Alcoholic Fatty Liver Disease

Perla, F. M., Prelati, M., Lavorato, M., Visicchio, D., & Anania, C. (2017) · Children · doi:10.3390/children4060046 · Cited by 129 · see citing works

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

Fernández-Checa, J. C., Bagnaninchi, P., Ye, H., Sancho‐Bru, P., Falcón‐Pérez, J. M., Royo, F., García‐Ruiz, C., Konu, Ö., Miranda, J. P., Lunov, O., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.06.021 · Cited by 129 · see citing works

Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

Rooyen, D. M. V., Gan, L. T., Yeh, M. M., Haigh, W. G., Larter, C. Z., Ioannou, G. N., Teoh, N., & Farrell, G. C. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.02.024 · Cited by 125 · see citing works

Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: Cause or consequence?

García‐Ruiz, C., Baulies, A., Marı́, M., García-Rovés, P. M., & Fernández-Checa, J. C. (2013) · Free Radical Research · doi:10.3109/10715762.2013.830717 · Cited by 116 · see citing works

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death

Montero, J., Marı́, M., Colell, A., Morales, A., Basáñez, G., García‐Ruiz, C., & Fernández-Checa, J. C. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.010 · Cited by 112 · see citing works

Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding

Wu, N., Sarna, L. K., Hwang, S., Zhu, Q., Wang, P., Siow, Y. L., & Karmin, O. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.024 · Cited by 111 · see citing works

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice

Wouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lütjohann, D., Kerksiek, A., Staels, B., Hofker, M. H., & Shiri-Sverdlov, R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.046 · Cited by 109 · see citing works

Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding

Pihlajamäki, J., Grönlund, S., Simonen, M., Käkelä, P., Moilanen, L., Pääkkönen, M. E., Pirinen, E., Kolehmainen, M., Kärjä, V. J., Kainulainen, S., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.10.004 · Cited by 108 · see citing works

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation

Aylon, Y., Gershoni, A., Rotkopf, R., Biton, I. E., Porat, Z., Koh, A. P., Sun, X., Lee, Y., Fiel, M.-I., Hoshida, Y., et al. (2016) · European Journal of Cancer · doi:10.1016/s0959-8049(16)61580-0 · Cited by 105 · see citing works

Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity

Zhang, D., Tong, X., VanDommelen, K., Gupta, N., Stamper, K., Brady, G. F., Meng, Z., Lin, J. D., Rui, L., Omary, M. B., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89934 · Cited by 107 · see citing works

Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis

Zhao, L., Chen, Y., Tang, R., Chen, Y., Li, Q., 龚建平, Huang, A., Varghese, Z., Moorhead, J. F., & Ruan, X. Z. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06560.x · Cited by 102 · see citing works

Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins

Walenbergh, S. M. A., Koek, G. H., Bieghs, V., & Shiri‐Sverdlov, R. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.11.014 · Cited by 101 · see citing works

STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway

de la Rosa, L. C., García‐Ruiz, C., Vallejo, C., Baulies, A., Núñez, S., Monte, M. J., Marı́n, J. J. G., Baila-Rueda, L., Cenarro, A., Civeira, F., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.01.028 · Cited by 101 · see citing works

Genomic aspects of NAFLD pathogenesis

Naik, A., Košir, R., & Rozman, D. (2013) · Genomics · doi:10.1016/j.ygeno.2013.03.007 · Cited by 101 · see citing works

Prebiotic approach alleviates hepatic steatosis: Implication of fatty acid oxidative and cholesterol synthesis pathways

Pachikian, B. D., Essaghir, A., Demoulin, J., Catry, É., Neyrinck, A. M., Dewulf, E. M., Sohet, F. M., Portois, L., Clerbaux, L., Carpentier, Y., et al. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200364 · Cited by 99 · see citing works

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

Wang, Y., Gunewardena, S., Li, F., Matye, D. J., Chen, C., Chao, X., Jung, T., Zhang, Y., Czerwiński, M., Ni, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17363-6 · Cited by 99 · see citing works

Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment

Byrne, C. D., Armandi, A., Pellegrinelli, V., Vidal‐Puig, A., & Bugianesi, E. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01045-z · Cited by 109 · see citing works

Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease

Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052668 · Cited by 95 · see citing works

Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues

Gliozzi, M., Musolino, V., Bosco, F., Scicchitano, M., Scarano, F., Nucera, S., Zito, M. C., Ruga, S., Carresi, C., Macrì, R., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105215 · Cited by 92 · see citing works

The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis

Rangboo, V., Noroozi, M., Zavoshy, R., Rezadoost, S. A., & Mohammadpoorasl, A. (2016) · International Journal of Hepatology · doi:10.1155/2016/4030476 · Cited by 93 · see citing works

Recent research trends and updates on nonalcoholic fatty liver disease

Yoo, J., Kim, W. K., Kim, M. Y., Jun, D. W., Kim, S. G., Yeon, J.-E., Lee, J. W., Cho, Y. K., Park, S. H., & Sohn, J. H. (2018) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2018.0037 · Cited by 92 · see citing works

Effects of High-Fat Diet on Steatosis, Endoplasmic Reticulum Stress and Autophagy in Liver of Tilapia (Oreochromis niloticus)

Jia, R., Cao, L., Du, J., He, Q., Gu, Z., Jeney, G., Xu, P., & Yin, G. (2020) · Frontiers in Marine Science · doi:10.3389/fmars.2020.00363 · Cited by 92 · see citing works

Chronic Alcohol Consumption Disrupted Cholesterol Homeostasis in Rats: Down‐Regulation of Low‐Density Lipoprotein Receptor and Enhancement of Cholesterol Biosynthesis Pathway in the Liver

Wang, Z., Yao, T., & Song, Z. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01111.x · Cited by 91 · see citing works

Lipoprotein subclass metabolism in nonalcoholic steatohepatitis

Männistö, V., Simonen, M., Soininen, P., Tiainen, M., Kangas, A. J., Kamińska, D., Venesmaa, S., Käkelä, P., Kärjä, V. J., Gylling, H., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.p054387 · Cited by 90 · see citing works

Hepatic iron loading in mice increases cholesterol biosynthesis†

Graham, R. M., Chua, A. C. G., Carter, K. W., Delima, R. D., Johnstone, D. M., Herbison, C. E., Firth, M. J., O’Leary, R., Milward, E. A., Olynyk, J. K., et al. (2010) · Hepatology · doi:10.1002/hep.23712 · Cited by 88 · see citing works

Testosterone Replacement Ameliorates Nonalcoholic Fatty Liver Disease in Castrated Male Rats

Nikolaenko, L., Jia, Y., Wang, C., Diaz‐Arjonilla, M., Yee, J. K., French, S. W., Liu, P. Y., Laurel, S., Chong, C., Lee, K., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1648 · Cited by 87 · see citing works

Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice

Jang, J. E., Park, H., Yoo, H. J., Baek, I., Yoon, J. E., Ko, M. S., Kim, A., Kim, H. S., Park, H., Lee, S. E., et al. (2017) · Hepatology · doi:10.1002/hep.29039 · Cited by 87 · see citing works

Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis

Bozaykut, P., Şahin, A., Karademir-Yilmaz, B., & Özer, N. K. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.07.001 · Cited by 86 · see citing works

Cholesterol Crystals in Hepatocyte Lipid Droplets Are Strongly Associated With Human Nonalcoholic Steatohepatitis

Ioannou, G. N., Landis, C. S., Jin, G., Haigh, W. G., Farrell, G. C., Kuver, R., Lee, S. P., & Savard, C. E. (2019) · Hepatology Communications · doi:10.1002/hep4.1348 · Cited by 84 · see citing works

Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways

García‐Ruiz, C., Mato, J. M., Vance, D. E., Kaplowitz, N., & Fernández-Checa, J. C. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.09.023 · Cited by 82 · see citing works

Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis

Chen, M., Xie, Y., Gong, S., Wang, Y., Yu, H., Zhou, T., Huang, F., Guo, X., Zhang, H., Huang, R., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105849 · Cited by 81 · see citing works

Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease

Wiering, L., Subramanian, P., & Hammerich, L. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.02.010 · Cited by 80 · see citing works

Chronic Administration of Proanthocyanidins or Docosahexaenoic Acid Reversess the Increase of miR-33a and miR-122 in Dyslipidemic Obese Rats

Baselga-Escudero, L., Arola-Arnal, A., Pascual-Serrano, A., Ribas-Latre, A., Casanova, E., Salvadó, M., Arola, L., & Bladé, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069817 · Cited by 80 · see citing works

Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease

Fengler, V. H., Macheiner, T., Kessler, S. M., Czepukojc, B., Gemperlein, K., Müller, R., Kiemer, A. K., Magnes, C., Haybaeck, J., Lackner, C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155163 · Cited by 78 · see citing works

Hypoxic Signaling and Cholesterol Lipotoxicity in Fatty Liver Disease Progression

Tirosh, O. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2548154 · Cited by 77 · see citing works

LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway

Chen, Z., Chen, L., Sun, B., Liu, D., He, Y., Qi, L., Li, G., Han, Z., Zhan, L., Zhang, S., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101230 · Cited by 77 · see citing works

Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors

Wang, K., Tanimoto, A., Yamada, S., Guo, X., Ding, Y., Watanabe, T., Watanabe, T., Kohno, K., Hirano, K., Tsukada, H., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091198 · Cited by 76 · see citing works

Hepatic miR‐33a/miR‐144 and their target gene ABCA1 are associated with steatohepatitis in morbidly obese subjects

Vega-Badillo, J., Gutiérrez-Vidal, R., Hernández-Pérez, H. A., Villamil-Ramírez, H., León-Mimila, P., Sánchez-Muñoz, F., Morán-Ramos, S., Larrieta‐Carrasco, E., Fernández-Silva, I., Méndez-Sánchez, N., et al. (2016) · Liver international (Print) · doi:10.1111/liv.13109 · Cited by 71 · see citing works

Lack of FGF21 promotes NASH-HCC transition via hepatocyte-TLR4-IL-17A signaling

Zheng, Q., Martin, R. C. G., Shi, X., Pandit, H., Yu, Y., Liu, X., Guo, W., Tan, M., Bai, O., Meng, X., et al. (2020) · Theranostics · doi:10.7150/thno.45988 · Cited by 73 · see citing works

Molecular Interactions between NAFLD and Xenobiotic Metabolism

Naik, A., Belič, A., Zanger, U. M., & Rozman, D. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00002 · Cited by 73 · see citing works

Hepatic Macrophage as a Key Player in Fatty Liver Disease

Xu, L., Liu, W., Bai, F., Xu, Y., Liang, X., Ma, C., & Gao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708978 · Cited by 72 · see citing works

Sterol Regulatory Element-Binding Factor 2 (SREBF-2) Predicts 7-Year NAFLD Incidence and Severity of Liver Disease and Lipoprotein and Glucose Dysmetabolism

Musso, G., Cassader, M., Bo, S., Michieli, F. D., & Gambino, R. (2012) · Diabetes · doi:10.2337/db12-0858 · Cited by 70 · see citing works

Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice

Wang, C., Yuan, R.-S., Zhuang, W., Sun, J., Wu, J., Li, H., & Chen, J. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0358-5 · Cited by 69 · see citing works

The future of liver transplantation

Feng, S., Roll, G. R., Rouhani, F. J., & Fueyo, A. S. (2024) · Hepatology · doi:10.1097/hep.0000000000000873 · Cited by 67 · see citing works

Nonalcoholic Fatty Liver Disease

Paredes, A. H., Torres, D. M., & Harrison, S. A. (2012) · Clinics in Liver Disease · doi:10.1016/j.cld.2012.03.005 · Cited by 68 · see citing works

917 METHIONINE DEFICIENCY ACCOUNTS FOR THE LIVER DAMAGE OBSERVED IN A NUTRITIONAL MODEL OF NONALCOHOLIC STEATOHEPATITIS

Caballero, F., Fernandez, A., Fernández-Checa, J. C., & García‐Ruiz, C. (2008) · Journal of Hepatology · doi:10.1016/s0168-8278(08)60919-8 · Cited by 1 · see citing works

918 PROGRESSION OF CAROTIC ATHEROSCLEROTIC DAMAGE IS RELATED TO ALT VALUES

Fracanzani, A. L., Valenti, L., Burdick, L., Bertelli, C., Fatta, E., Maraschi, A., Pulixi, E. A., & Fargion, S. (2008) · Journal of Hepatology · doi:10.1016/s0168-8278(08)60920-4

Cholesterol and nonalcoholic fatty liver disease: Renewed focus on an old villain

Kerr, T. A., Davidson, N. O., Groszmann, R. J., Iwakiri, Y., & Taddei, T. H. (2012) · Hepatology · doi:10.1002/hep.26088 · Cited by 55 · see citing works

Impact of cholesterol metabolism and the LXRα-SREBP-1c pathway on nonalcoholic fatty liver disease

Enjoji (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000170 · Cited by 78 · see citing works

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

Min, H., Kapoor, A., Fuchs, M. A., Mirshahi, F., Zhou, H., Maher, J. W., Kellum, J. M., Warnick, R., Contos, M. J., & Sanyal, A. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.004 · Cited by 653 · see citing works