The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
Open accessAbstract
Black tea is one of the world's most popular beverages, and its health-promoting effects have been intensively investigated. The antiobesity and hypolipidemic effects of black tea have attracted increasing interest, but the mechanisms underlying these phenomena remain unclear. In the present study, the black tea major component theaflavins were assessed for their hepatic lipid-lowering potential when administered in fatty acid overload conditions both in cell culture and in an animal experimental model. We found that theaflavins significantly reduced lipid accumulation, suppressed fatty acid synthesis, and stimulated fatty acid oxidation. Furthermore, theaflavins also inhibited acetyl-coenzyme A carboxylase activities by stimulating AMP-activated protein kinase (AMPK) through the LKB1 and reactive oxygen species pathways. These observations support the idea that AMPK is a critical component of decreased hepatic lipid accumulation by theaflavin treatments. Our results show that theaflavins are bioavailable both in vitro and in vivo and may be active in the prevention of fatty liver and obesity.
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Cited by
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
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Impact of Dietary Polyphenols on Carbohydrate Metabolism
Hanhineva, K., Törrönen, R., Bondia-Pons, I., Pekkinen, J., Kolehmainen, M., Mykkänen, H., & Poutanen, K. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041365 · Cited by 1,157
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040569 · Cited by 495
Shen, C., Jiang, J., Yang, L., Wang, D., & Zhu, W. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13631 · Cited by 344
Wang, X., Liu, R., Zhang, W., Zhang, X., Liao, N., Wang, Z., Li, W., Qin, X., & Hai, C. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.014 · Cited by 172
Metadata
- Authors
- Lin, C.-L., Huang, H.-C., & Lin, J.-K.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 48
- Issue
- 11
- Pages
- 2334-2343
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2155730665
- Cited by
- 190
- References
- 6
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lin, C.-L., Huang, H.-C., & Lin, J.-K. (2007). Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. Journal of Lipid Research. https://doi.org/10.1194/jlr.m700128-jlr200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
