Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Open accessAbstract
Obesity and diabetes are the most prevailing health concerns worldwide and their incidence is increasing at a high rate, resulting in enormous social costs. Obesity is a complex disease commonly accompanied by insulin resistance and increases in oxidative stress and inflammatory marker expression, leading to augmented fat mass in the body. Diabetes mellitus (DM) is a metabolic disorder characterized by the destruction of pancreatic β cells or diminished insulin secretion and action insulin. Obesity causes the development of metabolic disorders such as DM, hypertension, cardiovascular diseases, and inflammation-based pathologies. Flavonoids are the secondary metabolites of plants and have 15-carbon skeleton structures containing two phenyl rings and a heterocyclic ring. More than 5000 naturally occurring flavonoids have been reported from various plants and have been found to possess many beneficial effects with advantages over chemical treatments. A number of studies have demonstrated the potential health benefits of natural flavonoids in treating obesity and DM, and show increased bioavailability and action on multiple molecular targets. This review summarizes the current progress in our understanding of the anti-obesity and anti-diabetic potential of natural flavonoids and their molecular mechanisms for preventing and/or treating obesity and diabetes.
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Flavonoids are characterized by a flavone ring and exert anti-inflammation and antioxidant properties.
“Flavonoids, a class of benzo-gamma-pyrone derivatives abundant in foods and plants, are characterized by a flavone ring and exert anti-inflammation and antioxidant properties [108].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [108]
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- Authors
- Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G.
- Affiliations
- Department of Animal Biotechnology, Animal Resources Research Center, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea
- Konkuk University (KR)
- Corresponding author
- Cho, Ssang-Goo
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-04-15
- Volume
- 17
- Issue
- 4
- Pages
- 569
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4849025
- OpenAlex
- W2341834065
- Cited by
- 495
- References
- 213
- Citations by year
- 2026: 19 · 2025: 42 · 2024: 51 · 2023: 77 · 2022: 55 · 2021: 59 · 2020: 70 · 2019: 56 · 2018: 36 · 2017: 27 · 2016: 3
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Konkuk University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Keywords
- flavonoids, obesity, diabetes mellitus, anti-obesity mechanisms, antidiabetic mechanism, insulin resistance, oxidative stress, inflammation, pancreatic beta cells, bioavailability, plant secondary metabolites
- MeSH terms
- Animals, Diabetes Mellitus, Flavonoids, Humans, Hypoglycemic Agents, Obesity, Anti-Obesity Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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