Cited by 495Natural Antidiabetic Agents StudiesPhytochemicals and Antioxidant ActivitiesFlavonoids in Medical Research

Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids

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Kawser Hossain, Mohammed, Abdal Dayem, Ahmed, Han, Jihae, Yin, Yingfu, Kim, Kyeongseok, Kumar Saha, Subbroto, Yang, Gwang-Mo, Choi, Hye +1 more·2016·International Journal of Molecular Sciences

Abstract

Obesity and diabetes are the most prevailing health concerns worldwide and their incidence is increasing at a high rate, resulting in enormous social costs. Obesity is a complex disease commonly accompanied by insulin resistance and increases in oxidative stress and inflammatory marker expression, leading to augmented fat mass in the body. Diabetes mellitus (DM) is a metabolic disorder characterized by the destruction of pancreatic β cells or diminished insulin secretion and action insulin. Obesity causes the development of metabolic disorders such as DM, hypertension, cardiovascular diseases, and inflammation-based pathologies. Flavonoids are the secondary metabolites of plants and have 15-carbon skeleton structures containing two phenyl rings and a heterocyclic ring. More than 5000 naturally occurring flavonoids have been reported from various plants and have been found to possess many beneficial effects with advantages over chemical treatments. A number of studies have demonstrated the potential health benefits of natural flavonoids in treating obesity and DM, and show increased bioavailability and action on multiple molecular targets. This review summarizes the current progress in our understanding of the anti-obesity and anti-diabetic potential of natural flavonoids and their molecular mechanisms for preventing and/or treating obesity and diabetes.

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  • Flavonoids are characterized by a flavone ring and exert anti-inflammation and antioxidant properties.

    “Flavonoids, a class of benzo-gamma-pyrone derivatives abundant in foods and plants, are characterized by a flavone ring and exert anti-inflammation and antioxidant properties [108].”

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Authors
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G.
Affiliations
  • Department of Animal Biotechnology, Animal Resources Research Center, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea
  • Konkuk University (KR)
Corresponding author
Cho, Ssang-Goo
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2016-04-15
Volume
17
Issue
4
Pages
569
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2341834065
Cited by
495
References
213
Citations by year
2026: 19 · 2025: 42 · 2024: 51 · 2023: 77 · 2022: 55 · 2021: 59 · 2020: 70 · 2019: 56 · 2018: 36 · 2017: 27 · 2016: 3
FWCI
5.99
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Konkuk University
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Keywords
flavonoids, obesity, diabetes mellitus, anti-obesity mechanisms, antidiabetic mechanism, insulin resistance, oxidative stress, inflammation, pancreatic beta cells, bioavailability, plant secondary metabolites
MeSH terms
Animals, Diabetes Mellitus, Flavonoids, Humans, Hypoglycemic Agents, Obesity, Anti-Obesity Agents

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