The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover
Open accessAbstract
Although neutral lipid storage droplets are ubiquitous in eukaryotic cells, very little is known about how their synthesis and turnover are controlled. Adipocyte differentiation-related protein (ADRP; also known as adipophilin) is found on the surface of lipid droplets in most mammalian cell types. To learn how ADRP affects lipid storage, we stably expressed the protein in human embryonic kidney 293 (HEK 293) cells, which express little endogenous ADRP. As expected, ADRP was targeted to the surface of lipid droplets and caused an increase in triacylglycerol (TAG) mass under both basal and oleate-supplemented conditions. At least part of the increased mass resulted from a 50% decrease in the rate of TAG hydrolysis in ADRP-expressing cells. Furthermore, ADRP expression increased the fraction of total cellular TAG that was stored in lipid droplets. ADRP expression induced a striking decrease in the association of adipose triglyceride lipase (ATGL) and mannose-6-phosphate receptor tail-interacting protein of 47 kDa with lipid droplets and also decreased the lipid droplet association of several other unknown proteins. Transient expression of ADRP in two other cell lines also reduced the lipid droplet association of catalytically inactive ATGL. We conclude that the reduced lipid droplet association of ATGL and/or other lipases may explain the decrease in TAG turnover observed in ADRP-expressing HEK 293 cells.
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Cites
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Cited by
Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
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Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.
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Not Just Fat: The Structure and Function of the Lipid Droplet
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Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling
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Metadata
- Authors
- Listenberger, L. L., Ostermeyer-Fay, A. G., Goldberg, E. B., Brown, W. J., & Brown, D. A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 48
- Issue
- 12
- Pages
- 2751-2761
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2131290128
- Cited by
- 301
- References
- 56
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Listenberger, L. L., Ostermeyer-Fay, A. G., Goldberg, E. B., Brown, W. J., & Brown, D. A. (2007). Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover. Journal of Lipid Research. https://doi.org/10.1194/jlr.m700359-jlr200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
