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A novel role for ABCA1-generated large pre-β migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion

Chung, Soonkyu, Gebre, Abraham K., Seo, Jeongmin, Shelness, Gregory S., Parks, John S.·2010·Journal of Lipid Research
DOI 10.1194/jlr.m900083-jlr200
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  • When HDL generation by ABCA1 transporters at hepatocytes is compromised, VLDL secretion is rapidly reversed due to elevated triacylglycerol biogeneration in the liver.

    “It is thought that when HDL generation by ABCA1 transporters at hepatocytes is compromised, VLDL secretion is rapidly reversed due to elevated triacylglycerol biogeneration in the liver.22–26”

    From Clinical diversity and molecular mechanism of VPS35L-associated Ritscher-Schinzel syndrome (2023) · cites this paper as [24]

    The paper reports that ABCA1 silencing reduced large nascent HDL formation and increased VLDL triglyceride secretion in rat hepatoma cells. It does not support a rapid reversal of VLDL secretion or attribute the change to increased liver triglyceride synthesis: the discussion states that cellular TG synthesis did not increase and instead proposes reduced PI3-kinase-mediated HDL signaling. (LLM, conf=0.86)

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Metadata

Authors
Chung, S., Gebre, A. K., Seo, J., Shelness, G. S., & Parks, J. S.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2010-04
Volume
51
Issue
4
Pages
729-742
ISSN
0022-2275
DOI
10.1194/jlr.m900083-jlr200
Cited by
6
References
0
Language
en
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