Acidification of the intimal fluid: the perfect storm for atherogenesis

Oxygen toxicity, oxygen radicals, transition metals and disease

Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026

On Respiratory Impairment in Cancer Cells

Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466

HIF-1α is essential for myeloid cell-mediated inflammation

Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.

van der Wal, A. C., Becker, A. E., van der Loos, C. M., & Das, P. K. (1994) · Circulation · doi:10.1161/01.cir.89.1.36 · Cited by 1,921

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341

The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity

Borén, J., & Williams, K. J. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000330 · Cited by 524

Targeting the Microenvironment of Vulnerable Atherosclerotic Plaques: An Emerging Diagnosis and Therapy Strategy for Atherosclerosis

Zhang, S., Liu, Y., Cao, Y., Zhang, S., Sun, J., Wang, Y., Song, S., & Zhang, H. (2022) · Advanced Materials · doi:10.1002/adma.202110660 · Cited by 192

A role for proteoglycans in vascular disease

Wight, T. N. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.019 · Cited by 167

Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis

Pham, L. M., Kim, E.-C., Ou, W., Phung, C. D., Nguyen, T. T., Pham, T. T., Poudel, K., Gautam, M., Nguyen, H. T., Jeong, J., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120677 · Cited by 136

Apolipoprotein B-containing lipoproteins in atherogenesis

Borén, J., Packard, C. J., & Binder, C. J. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01111-0 · Cited by 110

Oxidative stress biomarker triggered multiplexed tool for auxiliary diagnosis of atherosclerosis

Ma, Y., Sun, W. Y., Ye, Z., Liu, L., Li, M., Shang, J., Xu, X., Cao, H., Xu, L., Liu, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh1037 · Cited by 98

The role of Ca2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis

Wu, X., Ren, G., Zhou, R., Ge, J., & Chen, F. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0135-3 · Cited by 92

HDL functionality in reverse cholesterol transport — Challenges in translating data emerging from mouse models to human disease

Lee‐Rueckert, M., Escolá‐Gil, J. C., & Kovanen, P. T. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.03.004 · Cited by 93

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells

Teixeira, J., Basit, F., Swarts, H. G. P., Forkink, M., Oliveira, P. J., Willems, P. H. G. M., & Koopman, W. J. H. (2017) · Redox Biology · doi:10.1016/j.redox.2017.12.018 · Cited by 90

Atherosclerosis Treatment with Stimuli‐Responsive Nanoagents: Recent Advances and Future Perspectives

Maruf, A., Wang, Y., Yin, T., Huang, J., Wang, N., Durkan, C., Tan, Y., Wu, W., & Wang, G. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900036 · Cited by 85

Modified Lipoproteins Induce Arterial Wall Inflammation During Atherogenesis

Lorey, M. B., Öörni, K., & Kovanen, P. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.841545 · Cited by 82

Inflammatory endothelium-targeted and cathepsin responsive nanoparticles are effective against atherosclerosis

Fang, F., Ni, Y., Yu, H., Yin, H., Yang, F., Li, C., Sun, D., Pei, T., Ma, J., Li, D., et al. (2022) · Theranostics · doi:10.7150/thno.70896 · Cited by 79

Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism

Lee‐Rueckert, M., Canyelles, M., Tondo, M., Rotllán, N., Kovanen, P. T., Llorente‐Cortés, V., & Escolá‐Gil, J. C. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.05.002 · Cited by 68

Recent advances in targeted stimuli-responsive nano-based drug delivery systems combating atherosclerosis

Song, Y., Jing, H., Vong, L. B., Wang, J., & Li, N. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.10.055 · Cited by 66

Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View

Lee‐Rueckert, M., Lappalainen, J., Kovanen, P. T., & Escolá‐Gil, J. C. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.777822 · Cited by 59

Mitochondria orchestrate macrophage effector functions in atherosclerosis

Dumont, A., Lee, M., Barouillet, T., Murphy, A. J., & Yvan‐Charvet, L. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100922 · Cited by 60

Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

Liu, C.-L., Zhang, X., Liu, J., Wang, Y., Sukhova, G. K., Wojtkiewicz, G. R., Liu, T., Tang, R., Achilefu, S. A., Nahrendorf, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11983-3 · Cited by 52

Different Pathways of Cellular Cholesterol Efflux

Dergunov, A. D., & Baserova, V. B. (2022) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-022-01081-5 · Cited by 50

Functional role of extracellular vesicles and lipoproteins in the tumour microenvironment

Menard, J. A., Cerezo-Magaña, M., & Belting, M. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0480 · Cited by 50

Advances in Glycolysis Metabolism of Atherosclerosis

Xu, R., Yuan, W., & Wang, Z. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10311-3 · Cited by 41

Malate initiates a proton-sensing pathway essential for pH regulation of inflammation

Chen, Y., Shi, R.-C., Xiang, Y.-C., Li, F., Tang, H., He, G., Zhou, M. L., Feng, X.-Z., Tan, J.-D., Huang, P., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02076-9 · Cited by 38

Overfeeding Saturated Fat Increases LDL (Low-Density Lipoprotein) Aggregation Susceptibility While Overfeeding Unsaturated Fat Decreases Proteoglycan-Binding of Lipoproteins

Ruuth, M. K., Lahelma, M., Luukkonen, P. K., Lorey, M. B., Qadri, S. U., Sädevirta, S., Hyötyläinen, T., Kovanen, P. T., Hodson, L., Yki‐Järvinen, H., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315766 · Cited by 40

Aldose Reductase Inhibitor Engeletin Suppresses Pelvic Inflammatory Disease by Blocking the Phospholipase C/Protein Kinase C-Dependent/NF-κB and MAPK Cascades

Wang, C., La, L., Feng, H., Yang, Q. Z., Wu, F., Wang, C., Wu, J., Hou, L., Hou, C., & Liu, W. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05102 · Cited by 35

Aggregation Susceptibility of Low-Density Lipoproteins—A Novel Modifiable Biomarker of Cardiovascular Risk

Öörni, K., & Kovanen, P. T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081769 · Cited by 35

Dual‐Function Nanoscale Coordination Polymer Nanoparticles for Targeted Diagnosis and Therapeutic Delivery in Atherosclerosis

Lin, Y., Liu, J., Chong, S. Y., Ting, H. J., Tang, X., Yang, L., Zhang, S., Qi, X., Pei, P., Yi, Z., et al. (2024) · Small · doi:10.1002/smll.202401659 · Cited by 32

ApoB-100 Lipoprotein Complex Formation with Intima Proteoglycans as a Cause of Atherosclerosis and Its Possible Ex Vivo Evaluation as a Disease Biomarker

Hurt‐Camejo, E., & Camejo, G. (2018) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd5030036 · Cited by 32

Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA

Jayaraman, S., Haupt, C., & Gursky, O. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m071191 · Cited by 31

Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall

Öörni, K., Lehti, S., Sjövall, P., & Kovanen, P. T. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180530094819 · Cited by 28

Acyl Chain Disorder and Azelaoyl Orientation in Lipid Membranes Containing Oxidized Lipids

Ferreira, T. M., Sood, R., Bärenwald, R., Carlström, G., Topgaard, D., Saalwächter, K., Kinnunen, P. K. J., & Ollila, O. H. S. (2016) · Langmuir · doi:10.1021/acs.langmuir.6b00788 · Cited by 28

Targeting and promoting atherosclerosis regression using hybrid membrane coated nanomaterials via alleviated inflammation and enhanced autophagy

You, P., Mayier, A., Zhou, H., Yang, A., Fan, J., Ma, S., Liu, B., & Jiang, Y. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101386 · Cited by 27

Methionine oxidized apolipoprotein A‐I at the crossroads of HDL biogenesis and amyloid formation

Witkowski, A., Chan, G. K. L., Boatz, J. C., Li, N. J., Inoue, A. P., Wong, J. C., van der Wel, P. C. A., & Cavigiolio, G. (2018) · The FASEB Journal · doi:10.1096/fj.201701127r · Cited by 26

Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro

Ozawa, D., Nomura, R., Mangione, P. P., Hasegawa, K., Okoshi, T., Porcari, R., Bellotti, V., & Naiki, H. (2016) · Scientific Reports · doi:10.1038/srep29077 · Cited by 25

Pro-metastatic functions of lipoproteins and extracellular vesicles in the acidic tumor microenvironment

Bång-Rudenstam, A., Cerezo-Magaña, M., & Belting, M. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09786-5 · Cited by 25

Atherosclerosis treatment with nanoagent: potential targets, stimulus signals and drug delivery mechanisms

Luo, T., Zhang, Z., Xu, J., Liu, H., Cai, L., Huang, G., Wang, C., Chen, Y., Xia, L., Ding, X., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1205751 · Cited by 24

Enhanced Anti-Atherosclerotic Efficacy of pH-Responsively Releasable Ganglioside GM3 Delivered by Reconstituted High-Density Lipoprotein

Rong, T., Wei, B., Ao, M., Zhao, H., Li, Y., Zhang, Y., Qin, Y., Zhou, J., Zhou, F., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413624 · Cited by 22

Depletion of ATP and glucose in advanced human atherosclerotic plaques

Ekstrand, M., Widell, E., Hammar, A. K., Akyürek, L. M., Johansson, M., Fagerberg, B., Bergström, G. M. L., Levin, M. C., Fogelstrand, P., Borén, J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178877 · Cited by 22

Acidic extracellular pH promotes accumulation of free cholesterol in human monocyte-derived macrophages via inhibition of ACAT1 activity

Lee‐Rueckert, M., Lappalainen, J., Leinonen, H., Plihtari, R., Nordström, T., Åkerman, K. E. O., Öörni, K., & Kovanen, P. T. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.08.011 · Cited by 21

Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism

Li, X., Cai, P., Tang, X., Wu, Y., Zhang, Y., & Rong, X. (2024) · Metabolites · doi:10.3390/metabo14040217 · Cited by 23

Differential Effect of Extracellular Acidic Environment on IL-1β Released from Human and Mouse Phagocytes

Sušjan, P., Benčina, M., & Hafner‐Bratkovič, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197229 · Cited by 20

From iron-driven cell death to clot formation: The emerging role of ferroptosis in thrombogenesis

Ravari, F. K., Gorji, M. G., & Rafiei, A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118328 · Cited by 19

T-cell death-associated gene 8 accelerates atherosclerosis by promoting vascular smooth muscle cell proliferation and migration

Chen, L.-D., Zhu, W., Cheng, Y., Li, Z., Chen, Y.-Q., Yuan, Z., Lin, C.-Y., Jing, D.-D., Liu, Z., & Yan, P. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.01.017 · Cited by 19

Macrophages and Phospholipases at the Intersection between Inflammation and the Pathogenesis of HIV-1 Infection

Spadaro, F., Cecchetti, S., & Fantuzzi, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071390 · Cited by 20

Aldose reductase (AKR1B) deficiency promotes phagocytosis in bone marrow derived mouse macrophages

Singh, M., Kapoor, A., McCracken, J., Hill, B. G., & Bhatnagar, A. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.01.012 · Cited by 17

Coordinate effects of P2X7 and extracellular acidification in microglial cells

Sekar, P., Huang, D.-Y., Chang, S., & Lin, W. (2018) · Oncotarget · doi:10.18632/oncotarget.24331 · Cited by 17

Lipids and lipoproteins in the interstitial tissue fluid regulate the formation of dysfunctional tissue-resident macrophages: Implications for atherogenic, tumorigenic, and obesogenic processes

Lee‐Rueckert, M., Jauhiainen, M., Kovanen, P. T., & Escolá‐Gil, J. C. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.008 · Cited by 16

Plaque‐Specific Adhesive Balloons Coated with Calcium Phosphate Nanoparticles Loaded with Rapamycin for Atherosclerosis Therapy

Xiao, Y., Lin, J., Zhao, Y., Wang, X., Lv, Q., Li, W., Tang, R., & Fu, G. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202315317 · Cited by 16

Response to retention hypothesis as a source of targets for arterial wall-directed therapies to prevent atherosclerosis: A critical review

Kumarapperuma, H., Chia, Z.-J., Malapitan, S. M., Wight, T. N., Little, P. J., & Kamato, D. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118552 · Cited by 19

Iron-binding cellular profile of transferrin using label-free Raman hyperspectral imaging and singular value decomposition (SVD)

Tubbesing, K. E., Khoo, T. C., Jangjoo, S. B., Sharikova, A. V., Barroso, M., & Khmaladze, A. T. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.04.030 · Cited by 16

Structural changes induced by acidic pH in human apolipoprotein B-100

Fernández-Higuero, J. Á., Benito‐Vicente, A., Etxebarria, A., Milicua, J. C. G., Ostolaza, H., Arrondo, J. L. R., & Martı́n, C. (2016) · Scientific Reports · doi:10.1038/srep36324 · Cited by 16

On-Demand Drug Delivery: Recent Advances in Cardiovascular Applications

Genç, H., Efthimiadou, E. Κ., & Cicha, I. (2022) · Frontiers in Drug Delivery · doi:10.3389/fddev.2022.913225 · Cited by 14

Acid-sensing ion channels: Linking extracellular acidification with atherosclerosis

Zhang, R.-J., Yin, Y., Xie, X., & Gu, H. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.12.027 · Cited by 14

Advancements in dual-targeting nanoparticle strategies for enhanced atherosclerosis therapy: Overcoming limitations of single-targeting approaches

Yang, C., Mo, L., Zhang, G., Dai, Y., Li, B., Tan, Z., Guo, Y., Lu, S., Hong, Y., He, H., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.09.023 · Cited by 13

AFM detects the effects of acidic condition on the size and biomechanical properties of native/oxidized low-density lipoprotein

Wang, K., Gan, C., Wang, H., Ao, M., Fan, Y., & Chen, Y. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112053 · Cited by 13

Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications

Li, Z., Ren, Y., Jiang, F., Zhang, K., Meng, X., Zheng, Y., & He, M. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02899-y · Cited by 12

Scavenger receptor-AI targeted theranostic nanoparticles for regression of atherosclerotic plaques via ABCA1 modulation

Zhu, Y., Xu, Y., Han, D. C., Zhang, X., Qin, C., Liu, J., Tian, L., Xu, M., Fang, Y., Zhang, Y., et al. (2023) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2023.102672 · Cited by 12

Construction of a pH/TGase “Dual Key”-Responsive Gold Nano-radiosensitizer with Liver Tumor-Targeting Ability

Zhang, Z., Niu, X., Feng, X., Wang, X., Yu, L., Wang, W., & Yuan, Z. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00428 · Cited by 12

Macrophage-Targeted Nanomedicine for the Treatment of Atherosclerosis

Feng, Y., Chen, J., Guo, X., Qin, M., Wang, S., Jiang, D., Liu, X., & Mao, L. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s529988 · Cited by 12

Proteomic Profiling of Endothelial Cell Secretomes After Exposure to Calciprotein Particles Reveals Downregulation of Basement Membrane Assembly and Increased Release of Soluble CD59

Stepanov, A. D., Shishkova, D. K., Markova, V. E., Markova, Y. O., Frolov, A. V., Lazebnaya, A. A., Oshchepkova, K., Perepletchikova, D. A., Smirnova, D., Basovich, L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111382 · Cited by 11

Beyond cholesterol: linking the conformation of apolipoprotein B to atherogenesis

Öörni, K., & Lorey, M. B. (2025) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000997 · Cited by 11

Redox-responsive polyurethane-polyurea nanoparticles targeting to aortic endothelium and atherosclerosis

Zhou, Y., Hou, D., Cuscó, C., Bonelli, J., Rocas, P., Cheng, F., Yang, X., Rocas, J., Hamberg, N. M., & Han, J. (2022) · iScience · doi:10.1016/j.isci.2022.105390 · Cited by 11

Ligand-receptor interaction in the specific targeting of biomimetic peptide nanoparticles to lysophosphatidylcholine

Wang, A., Yue, K., Zhong, W., Zhang, G., Wang, L., Wang, H., Zhang, H., & Zhang, X. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.162 · Cited by 11

Recent Advances in Micro/Nanomotor for the Therapy and Diagnosis of Atherosclerosis

Qin, Y., Yi, J., Chen, Y.-J., Zhang, W., & Tang, S.-F. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c15165 · Cited by 10

Restoring cholesterol efflux in vascular smooth muscle cells transitioning into foam cells through Liver X receptor activation

Borràs, C., Rotllán, N., Griñán, R., Santos, D., Solé, A., Dong, C., Zhao, Q., Llorente‐Cortés, V., Mourín, M., Soto, B., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118178 · Cited by 10

Structural analysis of a natural apolipoprotein A-I variant (L60R) associated with amyloidosis

Gaddi, G. M., Gisonno, R. A., Rosu, S. A., Curto, L. M., Prieto, E. D., Schinella, G. R., Finarelli, G. S., Cortez, M. F., Bauzá, L., Elías, E. E., et al. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108347 · Cited by 10

Imaging and Targeting Coronary Artery Inflammation

West, H. W., & Antoniades, C. A. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8128 · Cited by 10

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

Demandt, J. A. F., Dubois, L. J., van Kuijk, K., Zaťovičová, M., Jin, H., Parkkila, S., van der Laan, S. W., Jelenska, L., Mees, B. M. E., Reutelingsperger, C. P. M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-79978-5 · Cited by 9

Inflammation in atherosclerosis: a Big Idea that has underperformed so far

Williams, K. J. (2025) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000973 · Cited by 9

Differential cardiovascular impacts of sodium salts: unveiling the distinct roles of sodium chloride and sodium bicarbonate—consequences for heart failure patients

Sadki, D., Fawaz, S., Liegey, J.-S., Pucheu, Y., Boulestreau, R., Beuque, G., Foucher, J., Hein, L., & Couffinhal, T. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf020 · Cited by 9

Whole-Transcriptome Sequencing: A Powerful Tool for Vascular Tissue Engineering and Endothelial Mechanobiology

Kutikhin, A. G., Sinitsky, M. Y., Yuzhalin, A. E., & Velikanova, E. A. (2018) · Microarrays · doi:10.3390/ht7010005 · Cited by 10

Enhanced Vascular Smooth Muscle Cell and Extracellular Matrix Repair Using a Metal‐Organic Framework‐Based Co‐Delivery System for Abdominal Aortic Aneurysm Therapy

Lei, J., Dong, X., Huang, Y. Z., Wu, Z., Peng, Z., Li, B., Wang, R., Pan, Y., Zheng, X., Zhao, Z., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402937 · Cited by 8

pH-Dependent Protonation of Histidine Residues Is Critical for Electrostatic Binding of Low-Density Lipoproteins to Human Coronary Arteries

Glise, L., Rutberg, M., Håversen, L., Levin, M. C., Levin, M., Jeppsson, A., Borén, J., & Fogelstrand, P. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.317868 · Cited by 8

mPEG@ELA-11 Alleviates Atherosclerosis via AKT-ER Stress-Mediated Macrophage Modulation

Li, X., Dou, N., Zhong, L., Wu, Y., Cai, Z., Zhao, Z., Qu, L., & Jiang, Q. (2025) · BME Frontiers · doi:10.34133/bmef.0203 · Cited by 8

Investigating layer-by-layer chitosan-dextran sulfate-coated mesoporous silica as a pH-sensitive drug delivery system

Hooshyar, M. R., Raygan, S., & Aghdam, R. M. (2024) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-024-06797-9 · Cited by 8

Denaturation of human plasma high-density lipoproteins by urea studied by apolipoprotein A-I dissociation

Dergunov, A. D., Litvinov, D. Y., Malkov, A. A., Baserova, V. B., Nosova, E. V., & Dergunova, L. V. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158814 · Cited by 7

AFM reveals differential effects of acidification on LDL– and oxidized LDL–receptor interactions: biomechanical implications in atherogenesis

Wang, K., Sun, C., Zhuang, H., Jiang, X., & Chen, Y. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00715-9 · Cited by 6

Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors

Dai, J., Ding, X., Miyahara, H., Xu, Z., Cui, X., Igarashi, Y., Sawashita, J., Mori, M., & Higuchi, K. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1263274 · Cited by 6

Effects of lysosomal low-density lipoprotein oxidation by ferritin on macrophage function

Ojo, O. O., & Leake, D. S. (2022) · Free Radical Research · doi:10.1080/10715762.2022.2133703 · Cited by 5

Machine learning using scRNA-seq Combined with bulk-seq to identify lactylation-related hub genes in carotid arteriosclerosis

Liu, G., Song, Y., Yin, S., Zhang, B., & Han, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-00834-5 · Cited by 4

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Bogdanov, L. A., Velikanova, E. A., Shishkova, D. K., Рашитович, Ш. А., & Кутихин, А. Г. (2020) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2020.04.20-30 · Cited by 4

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Baserova, V. B., & Dergunov, A. D. (2021) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2021.140614 · Cited by 4

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Mehta, S., Ahamad, N., Dewani, M., Bhardwaj, P., & Banerjee, R. (2021) · Wiley eBooks · doi:10.1002/9783527832095.ch7 · Cited by 2

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Gaddi, G. M. (2020) · doi:10.35537/10915/110676

Valvular heart disease

Kovanen, P. T., & Bäck, M. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198755777.003.0015

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van Kuijk, K. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20210604kk

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Gaddi, G. M., Gisonno, R., Rosu, S. A., Curto, L. M., Elías, E. E., Prieto, E. D., Schinella, G. R., Finarelli, G. S., Cortez, M. F., Ramella, N. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/520171

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Deng, H. (2026) · Biology · doi:10.3390/biology15080642 · Cited by 1

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Smith, J. P., Duncan, A. M., Ellis, C. M., Kerckhoffs, A., Langton, M. J., & Davis, J. J. (2026) · Chemical Science · doi:10.1039/d6sc05306h

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Tie, S., Kuang, H., Xu, H., Guo, Q., Li, J., & Chen, L. (2026) · Cells · doi:10.3390/cells15151416

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Fu, Y., Hilal, M. E., Guo, W., Huang, K., Li, W., Dekyvere, S., Ma, Z., Liao, J., Chaemchuen, S., Liu, Y. S., et al. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127301

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Iakubovskaia, A., Niemelä, A., Benković, A., House, A. H., Pasternack, A. H., Mäntyselkä, P., Kornmueller, K., Koivuniemi, A., Ritvos, O., & Öörni, K. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101149

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Akkerman, V., Juhl, A. D., Egebjerg, J. M., Pratsch, C., Werner, S., Schneider, G., Willms, T., Müller, P. (. 1., Kapishnikov, S., & Wüstner, D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.22.753145

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Plihtari, R. (2010) · Työväentutkimus Vuosikirja · Cited by 1

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Rajamäki, K., Nordström, T., Öörni, K., Åkerman, K. E. O., Kovanen, P. T., & Eklund, K. K. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.32.suppl_1.a484

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Morgan, J., & Leake, D. S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80669-l · Cited by 29

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Plihtari, R., Kovanen, P. T., & Öörni, K. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.04.013 · Cited by 17

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Lee‐Rueckert, M., Lappalainen, J., Leinonen, H., Plihtari, R., Nordström, T., Åkerman, K. E. O., Öörni, K., & Kovanen, P. T. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.08.011 · Cited by 21