The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Oxidative stress and lipotoxicity
Open accessAbstract
The α,β polyunsaturated lipid aldehydes are potent lipid electrophiles that covalently modify lipids, proteins, and nucleic acids. Recent work highlights the critical role these lipids play under both physiological and pathological conditions. Protein carbonylation resulting from nucleophilic attack of lysine, histidine, and cysteine residues is a major outcome of oxidative stress and functions as a redox-sensitive signaling mechanism with roles in autophagy, cell proliferation, transcriptional control, and apoptosis. In addition, protein carbonylation is implicated as an initiating factor in mitochondrial dysfunction and endoplasmic reticulum stress, providing a mechanistic connection between oxidative stress and metabolic disease. In this review, we discuss the generation and metabolism of reactive lipid aldehydes, as well as their signaling roles.
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The sites and topology of mitochondrial superoxide production
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Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011
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Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis
Imai, H., Matsuoka, M., Kumagai, T., Sakamoto, T., & Koumura, T. (2016) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2016_508 · Cited by 623
Arroyave-Ospina, J. C., Wu, Z., Geng, Y., & Moshage, H. (2021) · Antioxidants · doi:10.3390/antiox10020174 · Cited by 527
Obesity, Inflammation, and Immune System in Osteoarthritis
Nedunchezhiyan, U., Varughese, I., Sun, A. R., Wu, X., Crawford, R., & Prasadam, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907750 · Cited by 466
Oxidative Stress and Huntington’s Disease: The Good, the Bad, and the Ugly
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Metadata
- Authors
- Hauck, A. K., & Bernlohr, D. A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 57
- Issue
- 11
- Pages
- 1976-1986
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2311234333
- Cited by
- 298
- References
- 11
- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
