The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Determinants of body fat distribution in humans may provide insight about obesity-related health risks
Open accessAbstract
Obesity increases the risks of developing cardiovascular and metabolic diseases and degrades quality of life, ultimately increasing the risk of death. However, not all forms of obesity are equally dangerous: some individuals, despite higher percentages of body fat, are at less risk for certain chronic obesity-related complications. Many open questions remain about why this occurs. Data suggest that the physical location of fat and the overall health of fat dramatically influence disease risk; for example, higher concentrations of visceral relative to subcutaneous adipose tissue are associated with greater metabolic risks. As such, understanding the determinants of the location and health of adipose tissue can provide insight about the pathological consequences of obesity and can begin to outline targets for novel therapeutic approaches to combat the obesity epidemic. Although age and sex hormones clearly play roles in fat distribution and location, much remains unknown about gene regulation at the level of adipose tissue or how genetic variants regulate fat distribution. In this review, we discuss what is known about the determinants of body fat distribution, and we highlight the important roles of sex hormones, aging, and genetic variation in the determination of body fat distribution and its contribution to obesity-related comorbidities.
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Cites
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Cited by
Contribution of adipogenesis to healthy adipose tissue expansion in obesity
Vishvanath, L., & Gupta, R. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129191 · Cited by 558
The impact of aging on adipose function and adipokine synthesis
Mancuso, P., & Bouchard, B. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00137 · Cited by 314
The Prebiotic Potential of Inulin-Type Fructans: A Systematic Review
Hughes, R. L., Alvarado, D. A., Swanson, K. S., & Holscher, H. D. (2022) · Advances in Nutrition · doi:10.1093/advances/nmab119 · Cited by 293
Aging and plasma triglyceride metabolism
Spitler, K. M., & Davies, B. S. J. (2020) · Journal of Lipid Research · doi:10.1194/jlr.r120000922 · Cited by 104
Venkatesh, V. S., Grossmann, M., Zajac, J. D., & Davey, R. A. (2022) · Obesity Reviews · doi:10.1111/obr.13429 · Cited by 22
Metadata
- Authors
- Frank, A. P., de Souza Santos, R., Palmer, B. F., & Clegg, D. J.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 60
- Issue
- 10
- Pages
- 1710-1719
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2885775983
- Cited by
- 304
- References
- 125
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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