Cited by 193Lipid metabolism and disordersParaoxonase enzyme and polymorphismsLipoproteins and Cardiovascular Health

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Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender and diet.

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Deeb, Samir S., Zambon, Alberto, Carr, Molly C., Ayyobi, Amir F., Brunzell, John D.·2003·Journal of Lipid Research

DOI 10.1194/jlr.r200017-jlr200

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Abstract

Hepatic lipase (HL) plays a central role in LDL and HDL remodeling. High HL activity is associated with small, dense LDL particles and with reduced HDL2 cholesterol levels. HL activity is determined by an HL gene promoter polymorphism, by gender (lower in premenopausal women), and by visceral obesity with insulin resistance. The activity is affected by dietary fat intake and selected medications. There is evidence for an interaction of the HL promoter polymorphism with visceral obesity, dietary fat intake, and with lipid-lowering medications in determining the level of HL activity. The dyslipidemia with high HL activity is a potentially proatherogenic lipoprotein profile in the metabolic syndrome, in Type 2 diabetes, and in familial combined hyperlipidemia.

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“This will ultimately lead to lower levels of HDL-C and a reduction in circulating HDL particles with impairment of reversed cholesterol transport [83].”
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“Small HDL in hypertriglyceridemia is associated with hypercatabolism of apolipoprotein A-I (47, 48), and it seems to be related to elevated hepatic lipase activity in central obesity and insulin resistance (49).”
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review Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet
Deeb, S. S., Zambon, A., Carr, M. C., Ayyobi, A. F., Brunzell, J. D., —deeb, C. H., Zambon, A., & Res, D. J. L. (2013)
A Hepatic Lipase Gene Promoter Polymorphism Attenuates the Increase in Hepatic Lipase Activity With Increasing Intra-abdominal Fat in Women
Carr, M. C., Hokanson, J. E., Deeb, S. S., Purnell, J. Q., Mitchell, E. S., & Brunzell, J. D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.11.2701 · Cited by 74
The Contribution of Intraabdominal Fat to Gender Differences in Hepatic Lipase Activity and Low/High Density Lipoprotein Heterogeneity
Carr, M. C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.6.2831 · Cited by 48
The Contribution of Intraabdominal Fat to Gender Differences in Hepatic Lipase Activity and Low/High Density Lipoprotein Heterogeneity1
Carr, M. C., Hokanson, J. E., Zambon, A., Deeb, S. S., Barrett, P. H. R., Purnell, J. Q., & Brunzell, J. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7586 · Cited by 120
Common Variants in the Promoter of the Hepatic Lipase Gene Are Associated With Lower Levels of Hepatic Lipase Activity, Buoyant LDL, and Higher HDL2Cholesterol
Zambon, A., Deeb, S. S., Hokanson, J. E., Brown, B. G., & Brunzell, J. D. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.11.1723 · Cited by 192
Association of variation in hepatic lipase activity with promoter variation in the hepatic lipase gene. The LOCAT Study Invsestigators.
Tahvanainen, E., Syvänne, M., Frick, M. H., Murtomäki-Repo, S., Antikainen, M., Kesäniemi, Y. A., Kauma, H., Pasternak, A., Taskinen, M., & Ehnholm, C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1144 · Cited by 117
The interactive effects of hepatic lipase gene promoter polymorphisms with sex and obesity on high-density-lipoprotein cholesterol levels in Taiwanese–Chinese
Ko, Y., Hsu, L., Hsu, K., Ko, Y.-H., & Lee, Y. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.09.013 · Cited by 52
Interactions of dietary fat intake and the hepatic lipase –480C→T polymorphism in determining hepatic lipase activity: the Hoorn Study
Bos, G., Dekker, J. M., Feskens, E. J. M., Ocké, M. C., Nijpels, G., Stehouwer, C. D. A., Bouter, L. M., Heine, R. J., & Jansen, H. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.4.911 · Cited by 19
Interactions of dietary fat intake and the hepatic lipase –480C3T polymorphism in determining hepatic lipase activity: the Hoorn Study1–3
Dekker, J. M., Feskens, E. J. M., Ocke, M. C., Nijpels, G., Stehouwer, C. D. A., Bouter, L. M., Heine, R. J., Jansen, H., & Nutr, J. C. (2015)
Gene-environment interaction in the regulation of HDL: The hepatic lipase gene promoter polymorpism modulates the physical activity associated increase in HDL
Hokanson, J. E., Hamman, R. F., Eckel, R. H., & Kamboh, M. I. (2001) · Circulation · doi:10.1161/circ.103.suppl_1.9998-8

Authors: Deeb, S. S., Zambon, A., Carr, M. C., Ayyobi, A. F., & Brunzell, J. D.
Affiliations: University of Washington (US)
Corresponding author: Deeb, Samir S.
ORCID: Zambon, Alberto
Brunzell, John D.
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 2003-07
Volume: 44
Issue: 7
Pages: 1279-1286
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1194/jlr.r200017-jlr200
OpenAlex: W2128832145
Cited by: 193
References: 80
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 12 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 8
FWCI: 2.51
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6267 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Heart, Lung, and Blood Institute (P01HL030086, HL3-0086, HL 64322, R01HL064322)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: hepatic lipase, dyslipidemia, visceral obesity, insulin resistance, dietary fat intake, gender differences, HDL cholesterol, small dense LDL, lipid-lowering drugs, metabolic syndrome, type 2 diabetes, familial combined hyperlipidemia, atherogenic lipoprotein profile
MeSH terms: Diabetes Mellitus, Type 2, Diet, Female, Haplotypes, Humans, Hyperlipidemias, Hyperlipidemia, Familial Combined, Lipase, Lipoproteins, LDL, Liver, Male, Models, Biological, Obesity, Polymorphism, Genetic, Promoter Regions, Genetic, Sex Factors, Genetic Variation

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Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender and diet.

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