The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The role of glycosphingolipid metabolism in the developing brain
Open accessAbstract
Glycosphingolipids (GSLs) are amphipathic lipids ubiquitously expressed in all vertebrate cells and body fluids, but they are especially abundant in the nervous system. The synthesis of GSLs generally is initiated in the endoplasmic reticulum and completed in the Golgi apparatus, followed by transportation to the plasma membrane surface as an integral component. The amount and expression patterns of GSLs change drastically in brains during the embryonic to postnatal stages. Recent studies have revealed that GSLs are highly localized in cell surface microdomains and function as important components that mediate signal transduction and cell adhesion. Also in developing brains, GSLs are suggested to play important roles in nervous system formation. Disturbance of GSL expression and metabolism affects brain function, resulting in a variety of diseases, particularly lysosomal storage diseases. In this review, we describe some aspects of the roles of GSLs, especially of gangliosides, in brain development.
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Cites
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Molecular machinery for non-vesicular trafficking of ceramide
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Hakomori, S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30565-3 · Cited by 879
The cell biology of lysosomal storage disorders
Futerman, A. H., & van Meer, G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1423 · Cited by 796
A vital role for glycosphingolipid synthesis during development and differentiation
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Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects
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Simpson, M. A., Cross, H., Proukakis, C., Priestman, D. A., Neville, D. C. A., Reinkensmeier, G., Wang, H., Wiznitzer, M., Gurtz, K., Verganelaki, A., et al. (2004) · Nature Genetics · doi:10.1038/ng1460 · Cited by 389
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Paranodal junction formation and spermatogenesis require sulfoglycolipids
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Cited by
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
Merrill, A. H. (2011) · Chemical Reviews · doi:10.1021/cr2002917 · Cited by 785
Structures, Biosynthesis, and Functions of Gangliosides-an Overview
Yu, R. K., Tsai, Y.-T., Ariga, T., & Yanagisawa, M. (2011) · Journal of Oleo Science · doi:10.5650/jos.60.537 · Cited by 416
Self-citationSphingolipids and gangliosides of the nervous system in membrane function and dysfunction
Posse de Chaves, E., & Sipione, S. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.12.010 · Cited by 274
Gangliosides: glycosphingolipids essential for normal neural development and function
Schengrund, C.-L. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.03.007 · Cited by 211
Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses
Kirkegaard, T., Gray, J., Priestman, D. A., Wallom, K.-L., Atkins, J., Olsen, O. D., Klein, A., Drndarski, S., Petersen, N. H. T., Ingemann, L., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9823 · Cited by 173
Metadata
- Authors
- Yu, R. K., Nakatani, Y., & Yanagisawa, M.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 50
- Pages
- S440-S445
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2045009404
- Cited by
- 268
- References
- 46
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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