The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structural and functional analysis of fatty acid-binding proteins
Open accessAbstract
The mammalian FA-binding proteins (FABPs) bind long-chain FA with high affinity. The large number of FABP types is suggestive of distinct functions in specific tissues. Multiple experimental approaches have shown that individual FABPs possess both unique and overlapping functions, some of which are based on specific elements in the protein structure. Although FA binding affinities for all FABPs tend to correlate directly with FA hydrophobicity, structure-function studies indicate that subtle three-dimensional changes that occur upon ligand binding may promote specific protein-protein or protein-membrane interactions that ultimately determine the function of each FABP. The conformational changes are focused in the FABP helical/portal domain, a region that was identified by in vitro studies to be vital for the FA transport properties of the FABPs. Thus, the FABPs modulate intracellular lipid homeostasis by regulating FA transport in the nuclear and extra-nuclear compartments of the cell; in so doing, they also impact systemic energy homeostasis.
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Cites
Crystal Structure and Thermodynamic Analysis of Human Brain Fatty Acid-binding Protein
Balendiran, G. K., Schnütgen, F., Scapin, G., Börchers, T., Xhong, N., Lim, K., Godbout, R., Spener, F., & Sacchettini, J. C. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61478-x · Cited by 217
Schug, T. T., Berry, D. C., Toshkov, I. A., Cheng, L., Nikitin, A. Y., & Noy, N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709981105 · Cited by 172
Altered emotional behavioral responses in mice lacking brain‐type fatty acid‐binding protein gene
Owada, Y., Abdelwahab, S. A., Kitanaka, N., Sakagami, H., Takano, H., Sugitani, Y., Sugawara, M., Kawashima, H., Kiso, Y., Mobarakeh, J. I., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04855.x · Cited by 154
Cited by
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
Rakhshandehroo, M., Knoch, B., Müller, M., & Kersten, S. (2010) · PPAR Research · doi:10.1155/2010/612089 · Cited by 1,020
Role of the Gut in Lipid Homeostasis
Abumrad, N. A., & Davidson, N. O. (2012) · Physiological Reviews · doi:10.1152/physrev.00019.2011 · Cited by 355
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
Legrand-Poels, S., Esser, N., L’homme, L., Scheen, A., Paquot, N., & Piette, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.013 · Cited by 194
Dubé, E., Gravel, A., Martin, C., Desparois, G., Moussa, I., Ethier-Chiasson, M., Forest, J.-C., Giguère, Y., Masse, A., & Lafond, J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.098095 · Cited by 180
Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics
Smathers, R. L., Fritz, K. S., Galligan, J. J., Shearn, C. T., Reigan, P., Marks, M. J., & Petersen, D. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038459 · Cited by 61
Metadata
- Authors
- Storch, J., & McDermott, L.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 50
- Pages
- S126-S131
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2034937725
- Cited by
- 296
- References
- 3
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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