Modulation of Fatty Acid Transport and Metabolism by Maternal Obesity in the Human Full-Term Placenta1
Abstract
Knowledge of the consequences of maternal obesity in human placental fatty acids (FA) transport and metabolism is limited. Animal studies suggest that placental uptake of maternal FA is altered by maternal overnutrition. We hypothesized that high maternal body mass index (BMI) affects human placental FA transport by modifying expression of key transporters. Full-term placentas were obtained by vaginal delivery from normal weight (BMI, 18.5-24.9 kg/m(2)) and obese (BMI > 30 kg/m(2)) women. Blood samples were collected from the mother at each trimester and from cord blood at delivery. mRNA and protein expression levels were evaluated with real-time RT-PCR and Western blotting. Lipoprotein lipase (LPL) activity was evaluated using enzyme fluorescence. In vitro linoleic acid transport was studied with isolated trophoblasts. Our results demonstrated that maternal obesity is associated with increased placental weight, decreased gestational age, decreased maternal high-density lipoprotein (HDL) levels during the first and third trimesters, increased maternal triglyceride levels during the second and third trimesters, and increased maternal T3 levels during all trimesters, and decreased maternal cholesterol (CHOL) and low-density lipoprotein (LDL) levels during the third trimester; and increased newborn CHOL, LDL, apolipoprotein B100, and T3 levels. Increases in placental CD36 mRNA and protein expression levels, decreased SLC27A4 and FABP1 mRNA and protein and FABP3 protein expression, and increased LPL activity and decreased villus cytotrophoblast linoleic acid transport were also observed. No changes were seen in expression of PPARA, PPARD, or PPARG mRNA and protein. Overall this study demonstrated that maternal obesity impacts placental FA uptake without affecting fetal growth. These changes, however, could modify the fetus metabolism and its predisposition to develop diseases later in life.
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There are changes in placental fatty acid transport and transporter expression in obese relative to lean women irrespective of the weight of their infants.
“There are also changes in placental fatty acid transport and transporter expression in obese relative to lean women irrespective of the weight of their infants (101, 156).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [156]
Cites
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038 · see citing works
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580 · see citing works
Wang, Y., Beydoun, M. A., Liang, L., Caballero, B. H., & Kumanyika, S. (2008) · Obesity · doi:10.1038/oby.2008.351 · Cited by 1,511 · see citing works
CD36 is a receptor for oxidized low density lipoprotein
Endemann, G., Stanton, L. W., Madden, K. S., Bryant, C. M., White, R. T., & Protter, A. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50272-1 · Cited by 1,282 · see citing works
Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
Schaffer, J. E., & Lodish, H. F. (1994) · Cell · doi:10.1016/0092-8674(94)90252-6 · Cited by 868 · see citing works
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 862 · see citing works
Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta
Challier, J. C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P. M., & Hauguel-de Mouzon, S. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.010 · Cited by 712 · cited 1× · see citing works
“Studies have reported mostly inflammatory changes in the placenta of obese women, such as an accumulation of immune cells (macrophages and neutrophils) and an increase in the expression of several inflammatory cytokines (interleukin-1 [IL-1], IL-6, tumor necrosis factor-a [TNF-a], IL-8) [40, 43, 44].”
BackgroundMaternal Obesity Is Associated with Dysregulation of Metabolic, Vascular, and Inflammatory Pathways
Ramsay, J. E., Ferrell, W. R., Crawford, L., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020311 · Cited by 659 · see citing works
Osmond, C., & Barker, D. J. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3545 · Cited by 656 · see citing works
Obesity and reproductive disorders in women
Pasquali, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg024 · Cited by 540 · see citing works
Serum Cholesterol in Young Men and Subsequent Cardiovascular Disease
Klag, M. J., Ford, D. E., Mead, L. A., He, J., Whelton, P. K., Liang, K., & Levine, D. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280504 · Cited by 518 · see citing works
Impact of maternal obesity on offspring obesity and cardiometabolic disease risk
Drake, A. J., & Reynolds, R. M. (2010) · Reproduction · doi:10.1530/rep-10-0077 · Cited by 501 · see citing works
Reinehr, T. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.06.005 · Cited by 500 · see citing works
Prepregnancy Obesity as a Risk Factor for Structural Birth Defects
Waller, D. K. (2007) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.161.8.745 · Cited by 466 · see citing works
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
Goldberg, I. J., Eckel, R. H., & Abumrad, N. A. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800085-jlr200 · Cited by 436 · see citing works
Increased neonatal fat mass, not lean body mass, is associated with maternal obesity
Sewell, M. F., Huston-Presley, L., Super, D. M., & Catalano, P. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.06.014 · Cited by 429 · see citing works
Zhang, H., Halbleib, M., Ahmad, F., Manganiello, V. C., & Greenberg, A. S. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2929 · Cited by 429 · see citing works
Identification of the Major Intestinal Fatty Acid Transport Protein
Stahl, A., Hirsch, D. J., Gimeno, R. E., Punreddy, S., Ge, P., Watson, N., Patel, S., Kotler, M., Raimondi, A., Tartaglia, L. A., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80332-9 · Cited by 424 · see citing works
Maternal metabolism and obesity: modifiable determinants of pregnancy outcome
Nelson, S. M., Matthews, P., & Poston, L. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp050 · Cited by 367 · see citing works
The effect of gestational weight gain by body mass index on maternal and neonatal outcomes
Crane, J. M. G., White, J., Murphy, P., Burrage, L., & Hutchens, D. (2009) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34050-6 · Cited by 363 · cited 1× · see citing works
“The rate of adverse outcomes such as hypertension and inadequate birth weight (,2500 g or 4000 g) is lower in obese women with low or recommended weight gain than in those with excess weight gain [41].”
BackgroundPlacental efficiency and adaptation: endocrine regulation
Fowden, A. L., Sferruzzi-Perri, A. N., Coan, P. M., Constância, M., & Burton, G. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173013 · Cited by 359 · see citing works
Thyroid Hormone Regulation of Hepatic Genes in Vivo Detected by Complementary DNA Microarray
Feng, X., Jiang, Y. Y., Meltzer, P. S., & Yen, P. M. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.7.0470 · Cited by 354 · see citing works
Placental regulation of fatty acid delivery and its effect on fetal growth--a review.
Haggarty, P. (2002) · Placenta · doi:10.1053/plac.2002.0791 · Cited by 349 · see citing works
Transport of fatty acids across the human placenta: A review
Duttaroy, A. K. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.11.001 · Cited by 349 · see citing works
Fatty Acid Supply to the Human Fetus
Haggarty, P. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104742 · Cited by 336 · see citing works
Maternal Lipid Metabolism and Placental Lipid Transfer
Herrera, E., Amusquivar, E., López‐Soldado, I., & Ortega, H. (2006) · Hormone Research in Paediatrics · doi:10.1159/000091507 · Cited by 322 · see citing works
Fatty acids and early human development
Innis, S. M. (2007) · Early Human Development · doi:10.1016/j.earlhumdev.2007.09.004 · Cited by 312 · see citing works
Interleukin-6 stimulates hepatic triglyceride secretion in rats
Nonogaki, K., Fuller, G. M., Fuentes, N. L., Moser, A. H., Staprãns, I., Grünfeld, C., & Feingold, K. R. (1995) · Endocrinology · doi:10.1210/endo.136.5.7720663 · Cited by 305 · see citing works
Structural and functional analysis of fatty acid-binding proteins
Storch, J., & McDermott, L. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800084-jlr200 · Cited by 297 · see citing works
Herrera, E. (2002) · Placenta · doi:10.1053/plac.2002.0771 · Cited by 295 · see citing works
Placental structure and inflammation in pregnancies associated with obesity
Roberts, K., Riley, S. C., Reynolds, R. M., Barr, S., Evans, M., Statham, A., Hor, K., Jabbour, H. N., Norman, J. E., & Denison, F. C. (2011) · Placenta · doi:10.1016/j.placenta.2010.12.023 · Cited by 281 · see citing works
Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
Koonen, D. P. Y., Glatz, J. F. C., Bonen, A., & Luiken, J. J. F. P. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.08.018 · Cited by 238 · see citing works
Magnusson, A., Waterman, I. J., Wennergren, M., Jansson, T., & Powell, T. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032234 · Cited by 206 · see citing works
Nickerson, J. G., Alkhateeb, H. H., Benton, C. R., Lally, J., Nickerson, J., Han, X.-X., Wilson, M. H., Jain, S. S., Snook, L. A., Glatz, J. F. C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004788 · Cited by 197 · see citing works
Schaiff, W. T., Bildirici, İ., Cheong, M., Chern, P. L., Nelson, D. M., & Sadovsky, Y. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2265 · Cited by 173 · see citing works
Energy intake misreporting among children and adolescents: a literature review
Forrestal, S. G. (2010) · Maternal and Child Nutrition · doi:10.1111/j.1740-8709.2010.00270.x · Cited by 162 · see citing works
Larqué, E., Krauss‐Etschmann, S., Campoy, C., Hartl, D., Linde, J., Klingler, M., Demmelmair, H., Caño, Á., Gil, Á., Bondy, B., et al. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.853 · Cited by 154 · see citing works
LXR is crucial in lipid metabolism
Ulven, S. M., Dalen, K. T., Gustafsson, J.-Α., & Nebb, H. I. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.009 · Cited by 154 · see citing works
Holdsworth‐Carson, S. J., Lim, R., Mitton, A., Whitehead, C. L., Rice, G. E., Permezel, M., & Lappas, M. (2010) · Placenta · doi:10.1016/j.placenta.2009.12.009 · Cited by 153 · see citing works
Farley, D. M., Choi, J., Dudley, D. J., Li, C., Jenkins, S. L., Myatt, L., & Nathanielsz, P. W. (2010) · Placenta · doi:10.1016/j.placenta.2010.06.006 · Cited by 150 · see citing works
L-FABP directly interacts with PPARα in cultured primary hepatocytes
Hostetler, H. A., McIntosh, A. L., Atshaves, B. P., Storey, S. M., Payne, H. R., Kier, A. B., & Schroeder, F. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900058-jlr200 · Cited by 147 · see citing works
Metabolic programming of long‐term outcomes due to fatty acid nutrition in early life
Innis, S. M. (2011) · Maternal and Child Nutrition · doi:10.1111/j.1740-8709.2011.00318.x · Cited by 145 · see citing works
Targeted Deletion of Fatty Acid Transport Protein-4 Results in Early Embryonic Lethality
Gimeno, R. E., Hirsch, D. J., Punreddy, S., Sun, Y., Ortegon, A. M., Wu, H., Daniels, T., Stricker‐Krongrad, A., Lodish, H. F., & Stahl, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309759200 · Cited by 144 · see citing works
CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs
Li, W., Febbraio, M., Reddy, S. P., Yu, D. Y., Yamamoto, M. P., & Silverstein, R. L. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42823 · Cited by 143 · see citing works
Campbell, F., Bush, P. G., Veerkamp, J. H., & Dutta-Roy, A. K. (1998) · Placenta · doi:10.1016/s0143-4004(98)90081-9 · Cited by 140 · see citing works
Krammer, J., Digel, M., Ehehalt, F., Stremmel, W., Füllekrug, J., & Ehehalt, R. (2011) · International Journal of Medical Sciences · doi:10.7150/ijms.8.599 · Cited by 121 · see citing works
Preferential uptake of long chain polyunsaturated fatty acids by isolated human placental membranes
Campbell, F., Gordon, M. J., & Duttaroy, A. K. (1996) · Molecular and Cellular Biochemistry · doi:10.1007/bf00714336 · Cited by 116 · see citing works
Hypoxia regulates the expression of fatty acid–binding proteins in primary term human trophoblasts
Biron‐Shental, T., Schaiff, W. T., Ratajczak, C. K., Bildirici, İ., Nelson, D. M., & Sadovsky, Y. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.03.066 · Cited by 115 · see citing works
Freeman, D. J. (2009) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2009.09.001 · Cited by 114 · see citing works
Jia, Z., Moulson, C. L., Pei, Z., Miner, J. H., & Watkins, P. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700568200 · Cited by 113 · see citing works
Campbell, F., Gordon, M. J., & Duttaroy, A. K. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00267-7 · Cited by 108 · see citing works
Effect of IL-6 and TNF-α on fatty acid uptake in cultured human primary trophoblast cells
Lager, S., Jansson, N., Olsson, A., Wennergren, M., Jansson, T., & Powell, T. L. (2010) · Placenta · doi:10.1016/j.placenta.2010.10.012 · Cited by 106 · see citing works
Induction of Human Liver X Receptor α Gene Expression Via an Autoregulatory Loop Mechanism
Li, Y., Bolten, C. W., Bhat, B. G., Woodring-Dietz, J., Li, S., Prayaga, S. K., Xia, C., & Lala, D. S. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.3.0789 · Cited by 97 · see citing works
Gene Expression Profiling and Its Relevance to the Blood-Epididymal Barrier in the Human Epididymis1
Dubé, É., Chan, P. T. K., Hermo, L., & Cyr, D. G. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.106.059246 · Cited by 92 · see citing works
Gestational and hormonal regulation of human placental lipoprotein lipase
Magnusson-Olsson, A. L., Hamark, B., Ericsson, A., Wennergren, M., Jansson, T., & Powell, T. L. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600098-jlr200 · Cited by 86 · see citing works
Prepregnancy Body Mass Index and Gestational Age-Dependent Changes in Lipid Levels During Pregnancy
Vahratian, A. M., Misra, V. K., Trudeau, S., & Misra, D. P. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181e45d23 · Cited by 74 · see citing works
Stability of reference proteins in human placenta: General protein stains are the benchmark
Lanoix, D., St‐Pierre, J., Lacasse, A., Viau, M., Lafond, J., & Vaillancourt, C. (2012) · Placenta · doi:10.1016/j.placenta.2011.12.008 · Cited by 74 · see citing works
Self-citationPaulussen, R. J. A., van Moerkerk, H. T. B., & Veerkam, J. H. (1990) · International Journal of Biochemistry · doi:10.1016/0020-711x(90)90142-p · Cited by 73 · see citing works
Melton, E. M., Cerny, R. L., Watkins, P. A., Dirusso, C., & Black, P. N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.226316 · Cited by 70 · see citing works
Plasma Membrane Fatty-Acid-Binding Protein in Human Placenta: Identification and Characterization
Campbell, F., Taffesse, S., Gordon, M. J., & Duttaroy, A. K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1598 · Cited by 65 · see citing works
Campbell, F., & Duttaroy, A. K. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01216-2 · Cited by 65 · see citing works
Xu, Y., Wang, Q., Cook, T. J., & Knipp, G. T. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20973 · Cited by 60 · see citing works
Liver X receptor-alpha gene expression is positively regulated by thyroid hormone.
Hashimoto, K., Matsumoto, S., Yamada, M., Satoh, T., & Mori, M. (2007) · Endocrinology · doi:10.1210/en.2007-0150 · Cited by 60 · see citing works
Han, S., & Sidell, N. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01404.x · Cited by 59 · see citing works
Daoud, G., Simoneau, L., Masse, A., Rassart, É., & Lafond, J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.11.017 · Cited by 54 · see citing works
Self-citationMaternal and umbilical fatty acid status in relation to maternal diet
Vriese, S. R. D., Matthys, C., Henauw, S. D., Backer, G. D., Dhont, M. A., & Christophe, A. B. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2002.0446 · Cited by 54 · see citing works
Matsuo, H., Maruo, T., Murata, K., & Mochizuki, M. (1993) · European Journal of Endocrinology · doi:10.1530/acta.0.1280225 · Cited by 54 · see citing works
Liu, D., Zang, C., Liu, H., Possinger, K., Fan, S.-G., & Elstner, E. (2004) · PubMed · Cited by 53 · see citing works
Larqué, E., Demmelmair, H., Klingler, M., de Jonge, S., Bondy, B., & Koletzko, B. V. (2006) · Early Human Development · doi:10.1016/j.earlhumdev.2006.02.001 · Cited by 52 · see citing works
Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity
Yan, J., Gong, Y., She, Y., Wang, G., Roberts, M. S., & Burczynski, F. J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900177-jlr200 · Cited by 50 · see citing works
Obesity and oxidative stress: a direct link to preeclampsia?
Zavalza-Gómez, A. B. (2010) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1753-1 · Cited by 50 · see citing works
Magnusson-Olsson, A. L., Lager, S., Jacobsson, B., Jansson, T., & Powell, T. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00571.2006 · Cited by 48 · see citing works
Obesity and gestational diabetes
Sathyapalan, T., Mellor, D. D., & Atkin, S. L. (2009) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2009.09.002 · Cited by 47 · see citing works
Circulating IL‐6 Concentrations and Abdominal Adipocyte Isoproterenol‐stimulated Lipolysis in Women
Morisset, A., Huot, C., Légaré, D., & Tchernof, A. (2008) · Obesity · doi:10.1038/oby.2008.242 · Cited by 47 · see citing works
Schreuder, Y. J., Hutten, B. A., van Eijsden, M., Jansen, E. H. J. M., Vissers, M. N., Twickler, M., & Vrijkotte, T. G. M. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.282 · Cited by 42 · see citing works
Rebholz, S. L., Burke, K. T., Yang, Q., Tso, P., & Woollett, L. A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00619.2010 · Cited by 42 · see citing works
Digel, M., Staffer, S., Ehehalt, F., Stremmel, W., Ehehalt, R., & Füllekrug, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00079.2011 · Cited by 37 · see citing works
Linoleic Acid Transport by Human Placental Syncytiotrophoblast Membranes
Lafond, J., Simoneau, L., Savard, R., & Gagnon, M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb20099.x · Cited by 33 · see citing works
Self-citationTriiodothyronine (T3) nuclear binding sites in human placenta and decidua
Banovac, K., Ryan, E. A., & O’Sullivan, M. J. (1986) · Placenta · doi:10.1016/s0143-4004(86)80140-0 · Cited by 28 · see citing works
Ethier-Chiasson, M., Forest, J., Giguère, Y., Masse, A., Marseille‐Tremblay, C., Levy, E. H., & Lafond, J. (2008) · Reproduction · doi:10.1530/rep-08-0082 · Cited by 27 · see citing works
Self-citationShafrir, E., Barash, V., Zederman, R., Kissilevitz, R., & Diamant, Y. Z. (1994) · PubMed · Cited by 18 · see citing works
Rosenson, R. S. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000168534.15085.5d · Cited by 17 · see citing works
Provost, P. R., & Tremblay, Y. (2010) · Early Human Development · doi:10.1016/j.earlhumdev.2010.06.013 · Cited by 9 · see citing works
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Catalano, P. M., & Shankar, K. (2017) · BMJ · doi:10.1136/bmj.j1 · Cited by 1,306 · see citing works
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Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Maternal–Fetal Nutrient Transport in Pregnancy Pathologies: The Role of the Placenta
Brett, K., Ferraro, Z. M., Yockell‐Lelièvre, J., Gruslin, A., & Adamo, K. B. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916153 · Cited by 459 · see citing works
Jansson, N., Rosario, F. J., Gaccioli, F., Lager, S., Jones, H. N., Roos, S., Jansson, T., & Powell, T. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2667 · Cited by 305 · see citing works
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Saben, J. L., Lindsey, F., Zhong, Y., Thakali, K. M., Badger, T. M., Andres, A., Gómez-Acevedo, H., & Shankar, K. (2014) · Placenta · doi:10.1016/j.placenta.2014.01.003 · Cited by 300 · see citing works
Tarrade, A., Panchenko, P., Junien, C., & Gabory, A. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110320 · Cited by 251 · see citing works
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Kelly, A. C., Powell, T. L., & Jansson, T. (2020) · Clinical Science · doi:10.1042/cs20190266 · Cited by 227 · see citing works
Xiong, L., Edwards, C. K., & Zhou, L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151017411 · Cited by 225 · see citing works
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Parlee, S. D., & MacDougald, O. A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.07.007 · Cited by 173 · see citing works
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Of the bugs that shape us: maternal obesity, the gut microbiome, and long-term disease risk
Gohir, W., Ratcliffe, E. M., & Sloboda, D. M. (2014) · Pediatric Research · doi:10.1038/pr.2014.169 · Cited by 150 · see citing works
Effect of Maternal Obesity on Placental Lipid Metabolism
Calabuig-Navarro, V., Haghiac, M., Minium, J., Glazebrook, P. A., Ranasinghe, G. C., Hoppel, C. L., Mouzon, S. H., Catalano, P., & O’Tierney-Ginn, P. (2017) · Endocrinology · doi:10.1210/en.2017-00152 · Cited by 144 · see citing works
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Larqué, E., Ruíz‐Palacios, M., & Koletzko, B. V. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835e3674 · Cited by 132 · see citing works
Placental transport in response to altered maternal nutrition
Gaccioli, F., Lager, S., Powell, T. L., & Jansson, T. (2013) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000529 · Cited by 129 · see citing works
Maternal Lipids and Fetal Overgrowth: Making Fat from Fat
Barbour, L. A., & Hernandez, T. L. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.08.007 · Cited by 133 · see citing works
Lee, H., Jang, M. K., Kim, H., Kwak, W., Park, W., Hwang, J. Y., Lee, C., Jang, G. W., Park, M. N., Kim, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066267 · Cited by 118 · see citing works
Fernandez-Twinn, D. S., Gascoin, G., Musial, B., Carr, S., Duque-Guimaraes, D., Blackmore, H. L., Alfaradhi, M. Z., Loche, E., Sferruzzi-Perri, A. N., Fowden, A. L., et al. (2017) · Scientific Reports · doi:10.1038/srep44650 · Cited by 115 · see citing works
Prieto‐Sánchez, M. T., Ruíz‐Palacios, M., Blanco‐Carnero, J. E., Pagán, A., Hellmuth, C., Uhl, O., Peißner, W., Ruiz‐Alcaraz, A. J., Parrilla, J. J., Koletzko, B. V., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.01.014 · Cited by 113 · see citing works
Heerwagen, M. J. R., Stewart, M. S., de la Houssaye, B. A., Janssen, R. C., & Friedman, J. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067791 · Cited by 111 · see citing works
Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition
Segura, M. T., Demmelmair, H., Krauss‐Etschmann, S., Nathan, P., Dehmel, S., Padilla, M. C., Rueda, R., Koletzko, B. V., & Campoy, C. (2017) · Placenta · doi:10.1016/j.placenta.2017.07.001 · Cited by 110 · see citing works
Review: Placental transport and metabolism of energy substrates in maternal obesity and diabetes
Gallo, L. A., Barrett, H. L., & Nitert, M. D. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.006 · Cited by 88 · see citing works
Maternal obesity modulates intracellular lipid turnover in the human term placenta
Hirschmugl, B., Desoyé, G., Catalano, P., Klymiuk, I., Scharnagl, H., Payr, S., Kitzinger, E., Schliefsteiner, C., Lang, U. E., Wadsack, C., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.188 · Cited by 86 · see citing works
Gaccioli, F., Aye, I. L. M. H., Roos, S., Lager, S., Ramirez, V. I., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0054-8 · Cited by 85 · see citing works
Placental Fatty Acid Transfer: A Key Factor in Fetal Growth
Larqué, E., Pagán, A., Prieto‐Sánchez, M. T., Blanco‐Carnero, J. E., Gil-Sánchez, A., Moreno, M. Z., Ruíz‐Palacios, M., Gázquez, A., Demmelmair, H., Parrilla, J. J., et al. (2014) · Annals of Nutrition and Metabolism · doi:10.1159/000365028 · Cited by 82 · see citing works
Álvarez, D., Muñoz, Y., Ortíz, M., Maliqueo, M. A., Chouinard‐Watkins, R., & Valenzuela, R. (2020) · Nutrients · doi:10.3390/nu13010019 · Cited by 81 · see citing works
Barbour, L. A., & Hernandez, T. L. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1008-2 · Cited by 80 · see citing works
Panchenko, P. E., Voisin, S. A. C., Jouin, M., Jouneau, L., Prézelin, A., Lecoutre, S., Breton, C., Jammes, H., Junien, C., & Gabory, A. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0188-3 · Cited by 77 · see citing works
Placental oleic acid uptake is lower in male offspring of obese women
Brass, E. P., Hanson, E., & O’Tierney-Ginn, P. F. (2013) · Placenta · doi:10.1016/j.placenta.2013.03.009 · Cited by 77 · see citing works
Lager, S., Ramirez, V. I., Gaccioli, F., Jang, B., Jansson, T., & Powell, T. L. (2016) · Placenta · doi:10.1016/j.placenta.2016.02.010 · Cited by 78 · see citing works
Wadhwani, N. S., Patil, V., Pisal, H., Joshi, A. A., Mehendale, S. S., Gupte, S., Wagh, G. N., & Joshi, S. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.05.006 · Cited by 76 · see citing works
Huang, X., Anderle, P., Hostettler, L., Baumann, M., Surbek, D., Ontsouka, E., & Albrecht, C. (2018) · BMC Genomics · doi:10.1186/s12864-018-4518-z · Cited by 72 · see citing works
Qiao, L., Guo, Z., Bosco, C., Guidotti, S., Wang, Y., Wang, M., Parast, M., Schaack, J., Hay, W. W., Moore, T. R., et al. (2015) · Diabetes · doi:10.2337/db14-1627 · Cited by 75 · see citing works
Role of Insulin in Placental Transport of Nutrients in Gestational Diabetes Mellitus
Ruíz‐Palacios, M., Ruiz‐Alcaraz, A. J., Sánchez-Campillo, M., & Larqué, E. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000455904 · Cited by 75 · see citing works
Díaz, P., Harris, J., Rosario, F. J., Powell, T. L., & Jansson, T. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00385.2015 · Cited by 72 · see citing works
McGrath, R. T., Glastras, S. J., HOCKING, S. L., & Fulcher, G. R. (2018) · Diabetes Care · doi:10.2337/dc18-0551 · Cited by 70 · see citing works
Reijnders, I. F., Mulders, A. G. M. G. J., van der Windt, M., Steegers, E. A. P., & Steegers‐Theunissen, R. P. M. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy037 · Cited by 68 · see citing works
Chassen, S. S., & Jansson, T. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.024 · Cited by 66 · see citing works
Arroyo‐Jousse, V., Jaramillo, A., Castaño‐Moreno, E., Lépez, M., Carrasco‐Negüe, K., & Casanello, P. C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165558 · Cited by 68 · see citing works
Effect of ω-3 supplementation on placental lipid metabolism in overweight and obese women
Calabuig-Navarro, V., Puchowicz, M., Glazebrook, P. A., Haghiac, M., Minium, J., Catalano, P. M., Mouzon, S. H., & O’Tierney-Ginn, P. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.124651 · Cited by 64 · see citing works
Distribution of Fatty Acids and Lipids During Pregnancy
Chavan, P., Rani, A., & Freeman, D. J. (2018) · Advances in clinical chemistry · doi:10.1016/bs.acc.2017.12.006 · Cited by 64 · see citing works
Gagné-Ouellet, V., Houde, A.-A., Guay, S.-P., Perron, P., Gaudet, D., Guérin, R., Jean-Patrice, B., Hivert, M.-F., Brisson, D., & Bouchard, L. (2017) · Epigenetics · doi:10.1080/15592294.2017.1322254 · Cited by 63 · see citing works
Dubé, É., Éthier‐Chiasson, M., & Lafond, J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.112.105619 · Cited by 62 · see citing works
Self-citationEffects of obesity and gestational diabetes mellitus on placental phospholipids
Uhl, O., Demmelmair, H., Segura, M. T., Florido, J., Rueda, R., Campoy, C., & Koletzko, B. V. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.05.032 · Cited by 60 · see citing works
Segovia, S. A., Vickers, M. H., & Reynolds, C. M. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417000204 · Cited by 62 · see citing works
Maternal obesity: new placental paradigms unfolded
Brombach, C., Tong, W., & Giussani, D. A. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.05.013 · Cited by 56 · see citing works
Uebel, K., Pusch, K., Gedrich, K., Schneider, K.-T. M., Hauner, H., & Bader, B. (2014) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-14-138 · Cited by 55 · see citing works
Lendvai, Á., Deutsch, M. J., Plösch, T., & Ensenauer, R. E. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00372.2015 · Cited by 57 · see citing works
Maternal PUFAs, Placental Epigenetics, and Their Relevance to Fetal Growth and Brain Development
Basak, S., & Duttaroy, A. K. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00989-w · Cited by 51 · see citing works
Placental lipoprotein lipase activity is positively associated with newborn adiposity
Heerwagen, M. J. R., Gumina, D. L., Hernandez, T. L., Pelt, R. E. V., Kramer, A. W., Janssen, R. C., Jensen, D. R., Powell, T. L., Friedman, J. E., Winn, V. D., et al. (2018) · Placenta · doi:10.1016/j.placenta.2018.03.001 · Cited by 51 · see citing works
Extensive load of somatic CNVs in the human placenta
Kasak, L., Rull, K., Vaas, P., Teesalu, P., & Laan, M. (2015) · Scientific Reports · doi:10.1038/srep08342 · Cited by 48 · see citing works
Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota
Basak, S., Mallick, R., Boga, N. S., & Duttaroy, A. K. (2024) · Nutrients · doi:10.3390/nu16121860 · Cited by 53 · see citing works
Effect of maternal obesity on pregnancy outcomes and long-term metabolic consequences
Valsamakis, G., Kyriazi, E., Mouslech, Z., Siristatidis, C. S., & Mastorakos, G. P. (2015) · HORMONES · doi:10.14310/horm.2002.1590 · Cited by 47 · see citing works
Maternal Obesity and Gut Microbiota Are Associated with Fetal Brain Development
Basak, S., Das, R. K., Banerjee, A., Paul, S., Pathak, S., & Duttaroy, A. K. (2022) · Nutrients · doi:10.3390/nu14214515 · Cited by 50 · see citing works
Wang, B., Liu, J.-J., Wang, Y., Fu, L., Shen, R., Yu, Z., Wang, H., Chen, Y.-H., Zhang, C., Meng, X., et al. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx052 · Cited by 46 · see citing works
Easton, Z. J. W., & Regnault, T. R. H. (2020) · Nutrients · doi:10.3390/nu12103031 · Cited by 44 · see citing works
Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions
Peng, L., Yang, H., Yao, Y., Ma, Z., Kühn, C., Rahmeh, M., Mahner, S., Makrigiannakis, A., Jeschke, U., & von Schönfeldt, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010433 · Cited by 42 · see citing works
Obesity in mares promotes uterine inflammation and alters embryo lipid fingerprints and homeostasis†
Sessions, D. R., Heuberger, A. L., & Carnevale, E. M. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy107 · Cited by 41 · see citing works
Developmental Programming of Pediatric Non-Alcoholic Fatty Liver Disease: Redefining the ‘First-Hit’
Stewart, M. S., Heerwagen, M. J. R., & Friedman, J. (2013) · Clinical obstetrics and gynecology · doi:10.1097/grf.0b013e3182a09760 · Cited by 47 · see citing works
Altered materno-fetal transfer of 13C-polyunsaturated fatty acids in obese pregnant women
Gázquez, A., Prieto‐Sánchez, M. T., Blanco‐Carnero, J. E., Ruíz‐Palacios, M., Díaz, A. N., van Harskamp, D., Oosterink, J. E., Schierbeek, H., van Goudoever, J. B., Demmelmair, H., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.04.014 · Cited by 39 · see citing works
Basak, S., Vilasagaram, S., & Duttaroy, A. K. (2020) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2020.102109 · Cited by 39 · see citing works
Placental Lipases in Pregnancies Complicated by Gestational Diabetes Mellitus (GDM)
Barrett, H. L., Kubala, M. H., Scholz‐Romero, K., Denny, K. J., Woodruff, T. M., McIntyre, D. H., Callaway, L. K., & Nitert, M. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104826 · Cited by 39 · see citing works
Placental lipid processing in response to a maternal high-fat diet and diabetes in rats
Louwagie, E. J., Larsen, T. D., Wachal, A. L., & Baack, M. L. (2017) · Pediatric Research · doi:10.1038/pr.2017.288 · Cited by 37 · see citing works
Zhang, N., Wang, L., Luo, G., Tang, X., Ma, L., Zheng, Y., Liu, S., Price, C. A., & Jiang, Z. (2019) · Animals · doi:10.3390/ani9060374 · Cited by 37 · see citing works
Diabetes Mellitus, Obesity, and the Placenta
Desoyé, G., & Cervar-Zivkovic, M. (2019) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2019.11.001 · Cited by 35 · see citing works
Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease
Myatt, L., & Thornburg, K. L. R. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_2 · Cited by 36 · see citing works
Alabduljabbar, S., Zaidan, S. A., Lakshmanan, A. P., & Terranegra, A. (2021) · Life · doi:10.3390/life11060467 · Cited by 34 · see citing works
O’Tierney-Ginn, P., Roberts, V. H. J., Gillingham, M. B., Walker, J., Glazebrook, P. A., Thornburg, K. L. R., Grove, K. L., & Frias, A. E. (2015) · Placenta · doi:10.1016/j.placenta.2015.06.002 · Cited by 33 · see citing works
Effects of Maternal Obesity On Placental Phenotype
Fowden, A. L., Camm, E. J., & Sferruzzi-Perri, A. N. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200513115316 · Cited by 35 · see citing works
Aparicio, E., Grau, C. M., Bedmar, C., Orus, N. S., Basora, J., Arija, V., & The ECLIPSES Study Group (2021) · Nutrients · doi:10.3390/nu13020317 · Cited by 32 · see citing works
The mystery of the life tree: the placentas
Shao, X., Yu, W., Yang, Y. Q., Wang, F., Yu, X., Wu, H., Ma, Y., Cao, B., & Wang, Y. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac095 · Cited by 32 · see citing works
Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy
Aparicio, E., Grau, C. M., Hernández‐Martínez, C., Voltas, N., Canals, J., & Arija, V. (2021) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-021-04251-0 · Cited by 31 · see citing works
Obesity downregulates lipid metabolism genes in first trimester placenta
Rasool, A., Mahmoud, T. G., Mathyk, B. A., Kaneko-Tarui, T., Roncari, D., White, K. O., & O’Tierney-Ginn, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-24040-9 · Cited by 30 · see citing works
The Effects of Maternal Obesity on Porcine Placental Efficiency and Proteome
Li, J.-W., Hu, J., Wei, M., Guo, Y., & Yan, P. (2019) · Animals · doi:10.3390/ani9080546 · Cited by 29 · see citing works
Human Placental Adaptive Changes in Response to Maternal Obesity: Sex Specificities
Santos, E. D., Hernández, M. H., Serazin-Leroy, V., Vialard, F., & Dieudonné, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119770 · Cited by 28 · see citing works
James‐Allan, L. B., Teal, S. B., Powell, T. L., & Jansson, T. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00173-y · Cited by 30 · see citing works
The Effect of Gestational Age on Angiogenic Gene Expression in the Rat Placenta
Vaswani, K., Hum, M., Chan, H., Ryan, J., Wood‐Bradley, R. J., Nitert, M. D., Mitchell, M. D., Armitage, J. A., & Rice, G. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083762 · Cited by 29 · see citing works
Min, Y., Djahanbakhch, O., Hutchinson, J., Bhullar, A. S., Raveendran, M., Hallot, A., Eram, S., Namugere, I., Nateghian, S., & Ghebremeskel, K. (2014) · Diabetic Medicine · doi:10.1111/dme.12524 · Cited by 30 · see citing works
Oxidative Stress Impairs Fatty Acid Oxidation and Mitochondrial Function in the Term Placenta
Thomas, M. M., Haghiac, M., Grozav, C., Minium, J., Calabuig-Navarro, V., & O’Tierney-Ginn, P. (2018) · Reproductive Sciences · doi:10.1177/1933719118802054 · Cited by 27 · see citing works
Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity
Solis‐Paredes, J. M., y Sosa, S. E., Estrada‐Gutiérrez, G., Nava-Salazar, S., Ortega-Castillo, V., Rodríguez‐Bosch, M., Bravo-Flores, E., Espejel-Núñez, A., Tolentino‐Dolores, M., Gaona-Estudillo, R., et al. (2016) · International Journal of Endocrinology · doi:10.1155/2016/7015626 · Cited by 27 · see citing works
Ferchaud‐Roucher, V., Barner, K., Jansson, T., & Powell, T. L. (2019) · The FASEB Journal · doi:10.1096/fj.201802444r · Cited by 26 · see citing works
Brett, K., Ferraro, Z. M., Holčı́k, M., & Adamo, K. B. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1049522 · Cited by 26 · see citing works
Sun, S., Cao, C., Li, J., Meng, Q., Cheng, B., Shi, B., & Shan, A. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202001148 · Cited by 25 · see citing works
Ramsden, C. E., Makrides, M., Yuan, Z., Horowitz, M. S., Zamora, D., Yelland, L. N., Best, K. P., Jensen, J., Taha, A. Y., & Gibson, R. A. (2019) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2019.102041 · Cited by 24 · see citing works
Placental mobilization of free fatty acids contributes to altered materno-fetal transfer in obesity
Hirschmugl, B., Perazzolo, S., Sengers, B. G., Lewis, R. M., Gruber, M., Desoyé, G., & Wadsack, C. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00781-x · Cited by 24 · see citing works
Placenta and Placental Transport Function
Sadovsky, Y., & Jansson, T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00039-9 · Cited by 24 · see citing works
Liang, T., Jinglong, X., Dong, S., & Wen, A. (2018) · Animal Science Journal · doi:10.1111/asj.13064 · Cited by 24 · see citing works
Gam, C. M. B. F., Larsen, L. H., Mortensen, O. H., Engelbrechtsen, L., Poulsen, S. S., Qvortrup, K., Mathiesen, E. R., Damm, P., & Quistorff, B. (2017) · The Journal of Physiology · doi:10.1113/jp274838 · Cited by 23 · see citing works
Hashemipour, S., Javadi, E. H. S., Maleki, F., Esmailzadehha, N., Movahed, F., & Yazdi, Z. (2018) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2018.01.008 · Cited by 23 · see citing works
Gázquez, A., & Larqué, E. (2021) · Nutrients · doi:10.3390/nu13020511 · Cited by 22 · see citing works
Pinto, T. J. P., Farias, D. R., Rebelo, F. M., Lepsch, J., Vaz, J. D. S., Moreira, J. D., da Cunha, G. M., & Kac, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121151 · Cited by 22 · see citing works
Physical Activity During Pregnancy Is Associated with Increased Placental FATP4 Protein Expression
Hutchinson, K. A., Vuong, N., Mohammad, S., Everest, C., Leung, M. L., Bhattacharjee, J., & Adamo, K. B. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00210-w · Cited by 21 · see citing works
Song, L., Wang, N., Peng, Y., Sun, B., & Cui, W. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.12.018 · Cited by 22 · see citing works
Sanches, A. P. V., de Oliveira, J. L., Ferreira, M. S., Lima, B. D. S., Miyamoto, J. É., Simino, L. A. D. P., Torsoni, M. A., Torsoni, A. S., Milanski, M., & Ignácio-Souza, L. M. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108977 · Cited by 21 · see citing works
Liang, T., Dong, S., Hu, J., Yao, J., & Yan, P. (2017) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12735 · Cited by 21 · see citing works
Kimber-Trojnar, Ż., Patro-Małysza, J., Trojnar, M. P., Skórzyńska-Dziduszko, K., Bartosiewicz, J., Oleszczuk, J., & Leszczyńska‐Gorzelak, B. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120505 · Cited by 21 · see citing works
Prospective association of fetal liver blood flow at 30 weeks gestation with newborn adiposity
Ikenoue, S., Waffarn, F., Ohashi, M., Sumiyoshi, K., Ikenoue, C., Buß, C., Gillen, D. L., Simhan, H. N., Entringer, S., & Wadhwa, P. D. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.04.022 · Cited by 21 · see citing works
Liang, T., Wen, A., Dong, S., & Yan, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051206 · Cited by 21 · see citing works
Robles, M., Couturier‐Tarrade, A., Derisoud, E., Geeverding, A., Dubois, C., Dahirel, M., Aı̈oun, J., Prézelin, A., Calvez, J., Richard, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42941-0 · Cited by 20 · see citing works
Maréchal, L., Sicotte, B., Caron, V., Brochu, M., & Tremblay, A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab496 · Cited by 19 · see citing works
Tarui, T., Rasool, A., & O’Tierney-Ginn, P. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113910 · Cited by 20 · see citing works
- Authors
- Dubé, E., Gravel, A., Martin, C., Desparois, G., Moussa, I., Ethier-Chiasson, M., Forest, J.-C., Giguère, Y., Masse, A., & Lafond, J.
- Affiliations
- Université du Québec à Montréal (CA)
- Hôpital Saint-François d'Assise (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Corresponding author
- Lafond, Julie
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07-01
- Volume
- 87
- Issue
- 1
- Pages
- 14, 1-11
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2113432131
- Cited by
- 180
- References
- 83
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 14 · 2020: 15 · 2019: 18 · 2018: 17 · 2017: 23 · 2016: 20 · 2015: 15 · 2014: 11 · 2013: 10 · 2012: 3
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biology of Reproduction (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- maternal obesity, placenta, fatty acid uptake, fatty acid metabolism, CD36, SLC27A4, FABP1, FABP3, lipoprotein lipase, trophoblast, HDL cholesterol, triglycerides, thyroid hormones, peroxisome proliferator-activated receptors, umbilical cord blood, fetal programming, body mass index
- MeSH terms
- Fatty Acid Binding Protein 3, Base Sequence, Biological Transport, Active, Fatty Acids, Female, Hormones, Humans, Infant, Newborn, Lipids, Lipoprotein Lipase, Maternal-Fetal Exchange, Models, Biological, Obesity, Placenta, Pregnancy, Pregnancy Complications, Case-Control Studies, DNA Primers, CD36 Antigens, Linoleic Acid, Peroxisome Proliferator-Activated Receptors, Fatty Acid-Binding Proteins, Fatty Acid Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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