The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Role of Iron in the Pathogenesis of Experimental Allergic Encephalomyelitis and Multiple Sclerosis
Abstract
A bstract: Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are autoimmune disorders resulting in demyelination in the central nervous system (CNS). Pathologically, the blood‐brain barrier becomes damaged, macrophages and T cells enter into the CNS, oligodendrocytes and myelin are destroyed, astrocytes and microglia undergo gliosis, and axons become transected. Data from several biochemical and pharmacological studies indicate that free radicals participate in the pathogenesis of EAE, and iron has been implicated as the catalyst leading to their formation. The primary focus of this article is the examination of the role of iron in the pathogenesis of MS and EAE. Particular attention will be paid to the role and distribution of iron and proteins involved with iron metabolism (e.g., transferrin, ferritin, heme oxygenase‐1, etc.) in normal and disease states of myelin. Furthermore, therapeutic interventions aimed at iron, iron‐binding proteins, and substrates or products of iron‐catalyzed reactions leading to free radical production will be discussed.
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Cites
Axonal transection in the lesions of multiple sclerosis
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Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains
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Ferritin as a source of iron for oxidative damage
Reif, D. W. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90091-t · Cited by 357
Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats
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Perivascular iron deposition and other vascular damage in multiple sclerosis.
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Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice
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Cited by
Oxidative Stress and Neurotoxicity
Sayre, L. M., Perry, G., & Smith, M. A. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700210j · Cited by 867
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla
Bagnato, F., Hametner, S., Yao, B., van Gelderen, P., Merkle, H., Cantor, F. K., Lassmann, H., & Duyn, J. H. (2011) · Brain · doi:10.1093/brain/awr278 · Cited by 351
Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging
Haacke, E. M., Makki, M., Ge, Y., Maheshwari, M., Sehgal, V., Hu, J., Selvan, M., Wu, Z., Latif, Z., Xuan, Y., et al. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21676 · Cited by 329
Metadata
- Authors
- LEVINE, S. M., & CHAKRABARTY, A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2004-03
- Volume
- 1012
- Issue
- 1
- Pages
- 252-266
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2164863629
- Cited by
- 159
- References
- 9
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- LEVINE, S. M., & CHAKRABARTY, A. (2004). The Role of Iron in the Pathogenesis of Experimental Allergic Encephalomyelitis and Multiple Sclerosis. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1306.021
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
