Cell Injury by Electric Forces
Abstract
A bstract: The molecular architecture of biological systems is heavily influenced by the highly polar interactions of water. Thus, macromolecules such as proteins that are highly water soluble must be electrically polar. Energy generation methods needed to support cell metabolic processes depend on compartmentalizing mobile ions and thus require electrical ion transport barriers such as membranes. One consequence of these biological design constraints is vulnerability to injury by electrical forces. Supraphysiological electric forces cause damage to cells and tissues by disrupting cell membranes and altering the conformation of biomolecules. In addition, prolonged passage of electrical current leads to damage by thermal mechanisms. This review will focus on the non‐thermal effects.
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NTIRE's effectiveness is limited by probe size and might not achieve complete decellularization alone.
“Its effectiveness is limited by probe size and might not achieve complete decellularization alone.”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [54]
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- Authors
- LEE, R. C.
- Affiliations
- University of Chicago (US)
- Corresponding author
- LEE, RAPHAEL C.
- ORCID
- LEE, RAPHAEL C.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 1066
- Issue
- 1
- Pages
- 85-91
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2168647633
- Cited by
- 100
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 9 · 2013: 8 · 2012: 3
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM064757, R01 GM64757, R01 GM61101, R01GM061101)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- electric force, cell damage, electric current, cell membrane damage, biomolecule conformation, water polarity, thermal damage, electroporation
- MeSH terms
- Cell Membrane, Cells, Electricity, Humans, Membrane Proteins, Protein Denaturation, Electroporation
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