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Cited by 102Multiple Sclerosis Research StudiesEstrogen and related hormone effectsPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 111 of the 112 references it cites were found in a registry or an index.

A Potential Role for Estrogen in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

OFFNER, HALINA, POLANCZYK, MAGDALENA·2006·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1386.021
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Abstract

Abstract: The extensive literature and the work from our laboratory illustrate the large number of complex processes affected by estrogen that might contribute to the striking ability of 17‐β estradiol (E2) and its derivatives to inhibit clinical and histological signs of experimental autoimmune encephalomyelitis (EAE) in mice. These effects require sustained exposure to relatively low doses of exogenous hormone and offer better protection when initiated prior to induction of EAE. The E2 mediates inhibition of encephalitogenic T cells, inhibition of cell migration into central nervous system tissue, and neuroprotective effects that promote axon and myelin survival. E2 effects on EAE are mediated through Esr‐1(α receptor for E2) but not Esr‐2(β receptor for E2), as are its anti‐inflammatory and neuroprotective effects. A novel finding is that E2 upregulated the expression of FoxP3 that contributes to the activity of CD4 + CD25 + T regulatory cells (Treg). The protective effects of E2 in EAE suggest its use as a therapy for multiple sclerosis (MS). Possible risks may be minimized by using sub‐pregnancy levels of exogenous E2 that produced synergistic effects when used in combination with another immunoregulatory therapy. Alternatively, one might envision using E2 derivatives alone or in combination therapies in both male and female MS patients.

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Crossref · 10.1196/annals.1386.021

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Research works printed but not linked: 4

  1. Smith M.E., 1996, Gender influences EAE both before and after sexual maturation, FASEB J., 10, A1353
  2. Stimson W.H., 1976, An investigation into the immunosuppressive properties of estrogen, J. Endocrinol., 69, 42
  3. 10.1002/1521-4141(200104)31:4<1122::AID-IMMU1122>3.0.CO;2-P · DOI
  4. Matejuk A., 2003, 17β‐estradiol treatment profoundly down‐regulates gene expression in spinal cord tissue in mice protected from experimental autoimmune encephalomyelitis, Archi. Immunol. Ther. Exp., 51, 185

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Metadata

Authors
OFFNER, H., & POLANCZYK, M.
Affiliations
Oregon Health & Science University (US)
Corresponding author
OFFNER, HALINA
ORCID
OFFNER, HALINA
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2006-11
Volume
1089
Issue
1
Pages
343-372
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1386.021
OpenAlex
W2090865102
Cited by
102
References
112
Citations by year
2026: 3 · 2025: 4 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 1 · 2012: 11
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 40 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Multiple Sclerosis Society
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
estrogen, estradiol, experimental autoimmune encephalomyelitis, multiple sclerosis, estrogen receptor alpha, estrogen receptor beta, Foxp3, regulatory T cells, neuroprotection, encephalitogenic T cells, anti-inflammatory activity, immunomodulatory therapy, sex differences
MeSH terms
Animals, Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Estradiol, Estrogens, Humans, Multiple Sclerosis, Cytokines, T-Lymphocytes, Regulatory, Mice

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