The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dormant and Self‐Renewing Hematopoietic Stem Cells and Their Niches
Open accessAbstract
Abstract: In the mouse, over the last 20 years, a set of cell‐surface markers and activities have been identified, enabling the isolation of bone marrow (BM) populations highly enriched in hematopoietic stem cells (HSCs). These HSCs have the ability to generate multiple lineages and are capable of long‐term self‐renewal activity such that they are able to reconstitute and maintain a functional hematopoietic system after transplantation into lethally irradiated recipients. Using single‐cell reconstitution assays, various marker combinations can be used to achieve a functional HSC purity of almost 50%. Here we have used the differential expression of six of these markers (Sca1, c‐Kit, CD135, CD48, CD150, and CD34) on lineage‐depleted BM to refine cell hierarchies within the HSC population. At the top of the hierarchy, we propose a dormant HSC population (Lin−Sca1+c‐Kit+ CD48−CD150+CD34−) that gives rise to an active self‐renewing CD34+ HSC population. HSC dormancy, as well as the balance between self‐renewal and differentiation activity, is at least, in part, controlled by the stem cell niches individual HSCs are attached to. Here we review the current knowledge about HSC niches and propose that dormant HSCs are located in niches at the endosteum, whereas activated HSCs are in close contact to sinusoids of the BM microvasculature.
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Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362
Cited by
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Self-citationIFNα activates dormant haematopoietic stem cells in vivo
Essers, M. A. G., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A., & Trumpp, A. (2009) · Nature · doi:10.1038/nature07815 · Cited by 1,368
Self-citationIn Search of the In Vivo Identity of Mesenchymal Stem Cells
da Silva Meirelles, L., Caplan, A. I., & Nardi, N. B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1122 · Cited by 1,077
Cell cycle regulation in hematopoietic stem cells
Pietras, E. M., Warr, M. R., & Passegué, E. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102131 · Cited by 447
Mechanisms of Disease: Cancer stem cells--targeting the evil twin
Trumpp, A., & Wiestler, O. D. (2008) · Nature Clinical Practice Oncology · doi:10.1038/ncponc1110 · Cited by 199
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Metadata
- Authors
- WILSON, A., OSER, G. M., JAWORSKI, M., BLANCO‐BOSE, W. E., LAURENTI, E., ADOLPHE, C., ESSERS, M. A., MACDONALD, H. R., & TRUMPP, A.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2007-06
- Volume
- 1106
- Issue
- 1
- Pages
- 64-75
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2016818042
- Cited by
- 245
- References
- 3
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- green
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- WILSON, A., OSER, G. M., JAWORSKI, M., BLANCO‐BOSE, W. E., LAURENTI, E., ADOLPHE, C., ESSERS, M. A., MACDONALD, H. R., & TRUMPP, A. (2007). Dormant and Self‐Renewing Hematopoietic Stem Cells and Their Niches. Annals of the New York Academy of Sciences. https://doi.org/10.1196/annals.1392.021
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
