Defining the Epithelial Stem Cell Niche in Skin
Open accessAbstract
Many adult regenerative cells divide infrequently but have high proliferative capacity. We developed a strategy to fluorescently label slow-cycling cells in a cell type–specific fashion. We used this method to purify the label-retaining cells (LRCs) that mark the skin stem cell (SC) niche. We found that these cells rarely divide within their niche but change properties abruptly when stimulated to exit. We determined their transcriptional profile, which, when compared to progeny and other SCs, defines the niche. Many of the >100 messenger RNAs preferentially expressed in the niche encode surface receptors and secreted proteins, enabling LRCs to signal and respond to their environment.
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Quiescent stem cells that regenerate hair follicles reside in the bulge.
“Quiescent stem cells that are responsible for regenerating the hair follicles lie within the bulge of the hair follicles21,31,32”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [21]
Initiation of a new anagen cycle depends upon activation of a small number of quiescent stem cells that reside in the bulge.
“Initiation of a new anagen cycle depends upon activation of a small number of quiescent stem cells that reside in the bulge, a niche at the follicle base15–19.”
From Conditional telomerase induction causes proliferation of hair follicle stem cells (2005) · cites this paper as [18]
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- Authors
- Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E.
- Affiliations
- Howard Hughes Medical Institute (US)
- Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10021, USA.
- Corresponding author
- Fuchs, Elaine
- Venue
- Science
- Published
- 2004-01-16
- Volume
- 303
- Issue
- 5656
- Pages
- 359-363
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2405920
- OpenAlex
- W2161092951
- Cited by
- 2,031
- References
- 33
- Citations by year
- 2026: 32 · 2025: 41 · 2024: 60 · 2023: 53 · 2022: 65 · 2021: 58 · 2020: 77 · 2019: 75 · 2018: 66 · 2017: 89 · 2016: 72 · 2015: 107 · 2014: 121 · 2013: 121 · 2012: 133
- FWCI
- 89.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institutes of Health (2r01ar050452-21)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR063663, R01-AR050452)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- skin stem cells, stem cell niche, label-retaining cells, slow-cycling cells, cell cycle, niche signaling, cell surface receptors, secreted proteins
- MeSH terms
- Epidermal Cells, Animals, Cell Cycle, Cell Division, Cell Separation, Epidermis, Epithelial Cells, Gene Expression Regulation, Histones, Luminescent Proteins, Mice, Transgenic, Microscopy, Fluorescence, RNA, Messenger, Transcription, Genetic, Keratinocytes, Hair Follicle, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Multipotent Stem Cells, Green Fluorescent Proteins, Mice
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