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Cited by 300Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsOvarian cancer diagnosis and treatment

Relationship of chemotherapy-induced necrosis and surgical margins to local recurrence in osteosarcoma.

Picci, P, Sangiorgi, L, Rougraff, B T, Neff, J R, Casadei, R, Campanacci, M·1994·Journal of Clinical Oncology
DOI 10.1200/jco.1994.12.12.2699
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Abstract

PURPOSE AND METHODS: To assess patients with high-grade osteosarcoma treated at our institution for various prognostic factors for the development of local recurrence of disease. Follow-up data were available for all patients and the mean follow-up duration was 65 months in surviving patients. RESULTS: There were 28 local recurrences in this study (7%). Of these, only three patients (11%) were alive at the most recent follow-up point, 28, 53, and 54 months after local recurrence. None of 59 patients who were treated primarily with a radical amputation and none of 10 who underwent a rotationplasty developed local recurrence. Four of 48 patients (8%) who had wide amputations, one of whom had an intralesional amputation, and 23 of 237 (10%) who had limb-salvage surgery developed locally recurrent disease. Of 237 patients who underwent limb-sparing resection, three prognostic factors for local control were identified. The strongest association with local recurrence was chemotherapy response (P < .0001), followed closely by surgical margins (P = .0001). Older patients were more likely to have locally recurrent disease (P = .033), with each decade of life older than the first decade having a relative risk of 1.5 times greater per decade (SE = 0.16; 95% confidence interval, 0.034 to .0650). Factors that were not associated with local recurrence included sex, date of diagnosis, and anatomic site of disease. CONCLUSION: Chemotherapy-induced tumor necrosis and surgical margins are important prognostic factors for local control of patients with osteosarcoma.

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Crossref · 10.1200/jco.1994.12.12.2699

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22 of 22 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Osteosarcoma cells express high levels of GD2 antigen.

    “Osteosarcoma cells express high level GD2 antigen that can be a potential target [108].”

    From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [108]

  • Intralesional or marginal resections increase local recurrence rate, which is associated with reduced overall survival.

    “Otherwise, intralesional or marginal resections increase local recurrence rate, which is associated with reduced overall survival 2,134 .”

    From Osteosarcoma (2022) · cites this paper as [134]

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Authors
Picci, P., Sangiorgi, L., Rougraff, B. T., Neff, J. R., Casadei, R., & Campanacci, M.
Affiliations
Istituto Ortopedico Rizzoli (IT)
ORCID
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
1994-12
Volume
12
Issue
12
Pages
2699-2705
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.1994.12.12.2699
OpenAlex
W1911184691
Cited by
300
References
22
Citations by year
2026: 5 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 11 · 2020: 13 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 26 · 2013: 10 · 2012: 11
FWCI
4.22
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
  • Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
Keywords
osteosarcoma, local recurrence, surgical margins, limb-sparing surgery, amputation, rotationplasty, prognostic factors, chemotherapy response, age as risk factor, local control
MeSH terms
Adolescent, Adult, Age Factors, Aged, Amputation, Surgical, Antineoplastic Combined Chemotherapy Protocols, Bone Neoplasms, Child, Child, Preschool, Combined Modality Therapy, Follow-Up Studies, Humans, Middle Aged, Necrosis, Neoplasm Recurrence, Local, Prognosis, Retrospective Studies, Risk Factors, Osteosarcoma, Incidence, Survival Analysis

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