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Cited by 52Estrogen and related hormone effectsThyroid Disorders and TreatmentsBreast Cancer Treatment Studies

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Thyroid function test changes with adjuvant tamoxifen therapy in postmenopausal women with breast cancer.

Mamby, C C, Love, R R, Lee, K E·1995·Journal of Clinical Oncology
DOI 10.1200/jco.1995.13.4.854
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Abstract

PURPOSE: While tamoxifen has been shown to alter concentration of many hormones and their binding globulins, there have been conflicting results regarding its effects on thyroid function tests. We sought to clarify these effects by studying subjects in a controlled clinical trial. PATIENTS AND METHODS: We evaluated a subset of postmenopausal women who had participated in a longitudinal, double-blind, randomized, placebo-controlled toxicity study of tamoxifen 10 mg orally, twice daily. There were 14 subjects in both the tamoxifen and placebo groups. Measurement of thyroid-binding globulin (TBG), thyroxine uptake (T-Uptake), thyroxine (T4), and thyroid-stimulating hormone (TSH), and an indirect estimate of the free T4 index (FTI), were made for each subject before and after 3 months of treatment. RESULTS: For T-Uptake, T4, and TBG, there were significant increases in the mean change from baseline to 3 months in the tamoxifen group compared with the placebo group (P = .02, .0001, and .003, respectively), while there were no significant changes in the measured TSH and in the calculated FTI. CONCLUSION: We conclude that tamoxifen therapy in postmenopausal women results in increased TBG, with secondary increases in measured T-Uptake and T4 following. However, TSH and FTI levels are unchanged, and treated women remain eumetabolic.

Overview

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Crossref · 10.1200/jco.1995.13.4.854

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7 of 7 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Mamby, C. C., Love, R. R., & Lee, K. E.
Affiliations
University of Wisconsin–Madison (US)
ORCID
Love, R R
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
1995-04
Volume
13
Issue
4
Pages
854-857
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.1995.13.4.854
OpenAlex
W1804300286
Cited by
52
References
7
Citations by year
2023: 2 · 2022: 4 · 2021: 1 · 2020: 6 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 2
FWCI
1.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2r01ca050243-03)
  • National Cancer Institute (CA 50243)
  • National Center for Research Resources (RR03186)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
tamoxifen, thyroid function tests, thyroxine-binding globulin, thyroxine uptake, thyroxine, thyroid-stimulating hormone, free T4 index, postmenopausal women, breast cancer, adjuvant endocrine therapy
MeSH terms
Breast Neoplasms, Double-Blind Method, Female, Humans, Longitudinal Studies, Middle Aged, Tamoxifen, Thyroid Function Tests, Thyroid Gland, Thyrotropin, Thyroxine, Thyroxine-Binding Proteins, Postmenopause

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CoChat. (2026). Citation check: Thyroid function test changes with adjuvant tamoxifen therapy in postmenopausal women with breast cancer. https://app.cochat.ai/papers/10.1200/jco.1995.13.4.854
The paper
Mamby, C. C., Love, R. R., & Lee, K. E. (1995). Thyroid function test changes with adjuvant tamoxifen therapy in postmenopausal women with breast cancer. Journal of Clinical Oncology. https://doi.org/10.1200/jco.1995.13.4.854

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.