The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Molecular Biology of the Ewing’s Sarcoma/Primitive Neuroectodermal Tumor Family
Abstract
ABSTRACT: Ewing’s sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor family consistently associated with chromosomal translocation and functional fusion of the EWS gene to any of several structurally related transcription factor genes. Similar gene fusion events occur in other mesenchymal and hematopoietic tumors and are tumor-specific. The resulting novel transcription factor–like chimeric proteins are believed to contribute to tumor biology by aberrant regulation of gene expression altering critical controls of cell proliferation and differentiation. These tumor-specific molecular rearrangements are useful for primary diagnosis, may provide prognostic information, and present potential therapeutic targets. The recent advances in our understanding of the molecular biology of ES and PNET represent a paradigm for the application of the basic biology of neoplasia to clinical management of patients.
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Cites
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G., et al. (1992) · Nature · doi:10.1038/359162a0 · Cited by 1,907
Conserved Structures and Diversity of Functions of RNA-Binding Proteins
Burd, C. G., & Dreyfuss, G. (1994) · Science · doi:10.1126/science.8036511 · Cited by 1,877
Delattre, O., Zucman, J., Melot, T., Garau, X. S., Zucker, J.-M., Lenoir, G. M., Ambros, P. F., Sheer, D., Turc-Carel, C., Triche, T. J., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408043310503 · Cited by 1,107
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
Crozat, A., Åman, P., Mandahl, N., & Ron, D. (1993) · Nature · doi:10.1038/363640a0 · Cited by 894
The Ets family of transcription factors
WASYLYK, B., HAHN, S. L., & GIOVANE, A. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb19864.x · Cited by 842
Sorensen, P. H. B., Lessnick, S. L., Lopez-Terrada, D., Liu, X. F., Triche, T. J., & Denny, C. T. (1994) · Nature Genetics · doi:10.1038/ng0294-146 · Cited by 747
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Ewing, J. (1972) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.22.2.95 · Cited by 583
May, W. A., Gishizky, M. L., Lessnick, S. L., Lunsford, L. B., Lewis, B. C., Delattre, O., Zucman, J., Thomas, G., & Denny, C. T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5752 · Cited by 574
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Cited by
Folpe, A. L., Hill, C. E., Parham, D. M., O'Shea, P. A., & Weiss, S. W. (2000) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200012000-00010 · Cited by 340
EWS–ETS oncoproteins: The linchpins of Ewing tumors
Janknecht, R. (2005) · Gene · doi:10.1016/j.gene.2005.08.007 · Cited by 173
Exposure on Cell Surface and Extensive Arginine Methylation of Ewing Sarcoma (EWS) Protein
Belyanskaya, L. L., Gehrig, P. M., & Gehring, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011446200 · Cited by 86
Metadata
- Authors
- de Alava, E., & Gerald, W. L.
- Venue
- Journal of Clinical Oncology
- Published
- 2000-01-01
- Volume
- 18
- Issue
- 1
- Pages
- 204-204
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1838055093
- Cited by
- 360
- References
- 72
- FWCI
- 17.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- de Alava, E., & Gerald, W. L. (2000). Molecular Biology of the Ewing’s Sarcoma/Primitive Neuroectodermal Tumor Family. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2000.18.1.204
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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