The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
No Downstaging After Short-Term Preoperative Radiotherapy in Rectal Cancer Patients
Open accessAbstract
PURPOSE: In retrospective studies, total mesorectal excision (TME) surgery has been demonstrated to result in a reduction in the number of local recurrences of rectal cancer. Reports on improved local control after preoperative, hypofractionated radiotherapy have led to the introduction of a randomized multicenter trial to evaluate the effect of TME surgery with and without preoperative radiotherapy. Treatment with preoperative radiotherapy might have an effect on the pathologic characteristics that determine staging of rectal cancer. We investigated the occurrence of downstaging in rectal cancer patients treated with and without preoperative radiotherapy. PATIENTS AND METHODS: We analyzed the differences in tumor size, number of examined lymph nodes, tumor-node-metastasis stage, and histopathologic features in 1,321 patients entered onto a randomized trial. The trial compared preoperative radiotherapy (5 × 5 Gy) followed by TME surgery with TME surgery alone. Patients who had an interval of more than 10 days between the start of radiotherapy and surgery were excluded from analysis. RESULTS: Differences were observed in tumor size (P < .001) and total number of examined lymph nodes (P < .001). No difference in tumor or node classification was detected. The irradiated group demonstrated more poorly differentiated tumors as well as more mucinous tumors. CONCLUSION: In rectal cancer patients, short-term, preoperative radiotherapy with 5 × 5 Gy does not lead to downstaging if the interval between the start of radiotherapy and surgery does not exceed 10 days.
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Cites
Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer
(1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361402 · Cited by 2,517
Cited by
Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer
Kapiteijn, E., Marijnen, C. A. M., Nagtegaal, I. D., Putter, H., Steup, W. H., Wiggers, T., Rutten, H. J. T., Pahlman, L., Glimelius, B., van Krieken, J. H. J. M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010580 · Cited by 4,205
Self-citationLow Rectal Cancer: A Call for a Change of Approach in Abdominoperineal Resection
Nagtegaal, I. D., van de Velde, C. J. H., Marijnen, C. A. M., van Krieken, J. H. J. M., & Quirke, P. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.9231 · Cited by 573
Self-citationS3-Leitlinie „Kolorektales Karzinom” – Aktualisierung 2008
Schmiegel, W., Reinacher-Schick, A., Arnold, D., Graeven, U., Heinemann, V, Porschen, R., Riemann, J., Rödel, C., Sauer, R., Wieser, M., et al. (2008) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2008-1027726 · Cited by 274
Metadata
- Authors
- Marijnen, C. A. M., Nagtegaal, I. D., Kranenbarg, E. K., Hermans, J., van de Velde, C. J. H., Leer, J. W. H., van Krieken, J. H. J. M., & for the Pathology Review Committee and the Cooperative Clinical Investigators
- Venue
- Journal of Clinical Oncology
- Published
- 2001-04-01
- Volume
- 19
- Issue
- 7
- Pages
- 1976-1984
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2105768073
- Cited by
- 328
- References
- 1
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Marijnen, C. A. M., Nagtegaal, I. D., Kranenbarg, E. K., Hermans, J., van de Velde, C. J. H., Leer, J. W. H., van Krieken, J. H. J. M., & for the Pathology Review Committee and the Cooperative Clinical Investigators. (2001). No Downstaging After Short-Term Preoperative Radiotherapy in Rectal Cancer Patients. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2001.19.7.1976
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