The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Low Rectal Cancer: A Call for a Change of Approach in Abdominoperineal Resection
Open accessAbstract
Purpose: Despite the major improvements that have been made due to total mesorectal excision (TME), low rectal cancer still remains a challenge. Methods: By investigating a prospective randomized rectal cancer trial in which surgeons had undergone training in TME the factors responsible for the poor outcome were determined and a new method for assessing the quality of surgery was tested. Results: Survival differed greatly between abdominoperineal resection (APR) and anterior resection (AR; 38.5% v 57.6%, P = .008). Low rectal carcinomas have a higher frequency of circumferential margin involvement (26.5% v 12.6%, P < .001). More positive margins were present in the patients operated with APR (30.4%) compared to AR (10.7%, P = .002). Furthermore, more perforations were present in these specimens (13.7% v 2.5%, P < .001). The plane of resection lies within the sphincteric muscle, the submucosa or lumen in more than 1/3 of the APR cases, and in the remainder lay on the sphincteric muscles. Conclusion: We systematically described and investigated the pathologic properties of low rectal cancer in general, and APR in particular, in a prospective randomized trial including surgeons who had been trained in TME. The poor prognosis of the patients with an APR is ascribed to the resection plane of the operation leading to a high frequency of margin involvement by tumor and perforation with this current surgical technique. The clinical results of this operation could be greatly improved by adopting different surgical techniques and possibly greater use of radiochemotherapy.
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Cites
Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer
Kapiteijn, E., Marijnen, C. A. M., Nagtegaal, I. D., Putter, H., Steup, W. H., Wiggers, T., Rutten, H. J. T., Pahlman, L., Glimelius, B., van Krieken, J. H. J. M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010580 · Cited by 4,205
Self-citationThe mesorectum in rectal cancer surgery—the clue to pelvic recurrence?
Heald, R. J., Husband, E. M., & Ryall, R. D. H. (1982) · Journal of British Surgery · doi:10.1002/bjs.1800691019 · Cited by 2,917
LOCAL RECURRENCE OF RECTAL ADENOCARCINOMA DUE TO INADEQUATE SURGICAL RESECTION
Quirke, P., Dixon, M. F., Durdey, P., & Williams, N. S. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92612-7 · Cited by 1,973
Self-citationRole of circumferential margin involvement in the local recurrence of rectal cancer
Adam, I. J., Martin, I. G., Finan, P., Johnston, D., Mohamdee, M. O., Scott, N., Dixon, M. F., & Quirke, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92206-3 · Cited by 1,036
Self-citationNagtegaal, I. D., van de Velde, C. J. H., van der Worp, E., Kapiteijn, E., Quirke, P., van Krieken, J. H. J. M., & the Pathology Review Committee for the Cooperative Clinical Investigators of the Dutch Colorectal Cancer Group (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.07.010 · Cited by 922
Self-citationWibe, A., Møller, B., Norstein, J., Carlsen, E., Wiig, J. N., Heald, R. J., Langmark, F., Myrvold, H. E., & Søreide, O. (2002) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6317-7 · Cited by 570
The Modern Abdominoperineal Excision: The Next Challenge After Total Mesorectal Excision
Marr, R., Birbeck, K., Garvican, J., Macklin, C. P., Tiffin, N. J., Parsons, W. J., Dixon, M. F., Mapstone, N. P., Sebag-Montefiore, D., Scott, N., et al. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000167926.60908.15 · Cited by 436
Self-citationWibe, A., Syse, A., Andersen, E., Tretli, S., Myrvold, H. E., & Søreide, O. (2004) · Diseases of the Colon & Rectum · doi:10.1007/s10350-003-0012-y · Cited by 425
No Downstaging After Short-Term Preoperative Radiotherapy in Rectal Cancer Patients
Marijnen, C. A. M., Nagtegaal, I. D., Kranenbarg, E. K., Hermans, J., van de Velde, C. J. H., Leer, J. W. H., van Krieken, J. H. J. M., & for the Pathology Review Committee and the Cooperative Clinical Investigators (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.7.1976 · Cited by 328
Self-citationMarijnen, C. A. M., Nagtegaal, I. D., Kapiteijn, E., Kranenbarg, E. K., Noordijk, E. M., van Krieken, J. H. J. M., van de Velde, C. J. H., & Leer, J. W. H. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04291-8 · Cited by 261
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Battersby, N. J., Bouliotis, G., Emmertsen, K. J., Juul, T., Glynne-Jones, R., Branagan, G., Christensen, P., Laurberg, S., & Moran, B. J. (2018) · Gut · doi:10.1136/gutjnl-2016-312695 · Cited by 245
Metadata
- Authors
- Nagtegaal, I. D., van de Velde, C. J. H., Marijnen, C. A. M., van Krieken, J. H. J. M., & Quirke, P.
- Venue
- Journal of Clinical Oncology
- Published
- 2005-12-20
- Volume
- 23
- Issue
- 36
- Pages
- 9257-9264
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2150646677
- Cited by
- 573
- References
- 12
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nagtegaal, I. D., van de Velde, C. J. H., Marijnen, C. A. M., van Krieken, J. H. J. M., & Quirke, P. (2005). Low Rectal Cancer: A Call for a Change of Approach in Abdominoperineal Resection. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2005.02.9231
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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