The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Barriers to Clinical Trial Participation by Older Women With Breast Cancer
Abstract
Purpose: Although 48% of breast cancer patients are 65 years old or older, these older patients are severely underrepresented in breast cancer clinical trials. This study tested whether older patients were offered trials significantly less often than younger patients and whether older patients who were offered trials were more likely to refuse participation than younger patients. Patients and Methods: In 10 Cancer and Leukemia Group B institutions, using a retrospective case-control design, breast cancer patients eligible for an open treatment trial were paired: less than 65 years old and ≥ 65 years old. Each of the 77 pairs were matched by disease stage and treating physician. Patients were interviewed as to their reasons for participating or refusing to participate in a trial. The treating physicians were also given questionnaires about their reasons for offering or not offering a trial. Results: Sixty-eight percent of younger stage II patients were offered a trial compared with 34% of the older patients (P = .0004). In multivariate analyses, disease stage and age remained highly significant in predicting trial offering (P = .0008), when controlling for physical functioning and comorbidity. Of those offered a trial, there was no significant difference in participation between younger (56%) and older (50%) patients (P = .67). Conclusion: In a multivariate analysis including comorbid conditions, age and stage were the only predictors of whether a patient was offered a trial. The greatest impediment to enrolling older women onto trials in the setting of this study was the physicians’ perceptions about age and tolerance of toxicity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fukuoka, M., Yano, S., Giaccone, G., Tamura, T., Nakagawa, K., Douillard, J.-Y., Nishiwaki, Y., Vansteenkiste, J., Kudoh, S., Rischin, D., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.10.038 · Cited by 2,874
Underrepresentation of Patients 65 Years of Age or Older in Cancer-Treatment Trials
Hutchins, L. F., Unger, J. M., Crowley, J. J., Coltman, C. A., & Albain, K. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912303412706 · Cited by 2,174
Fillenbaum, G. G. (1988) · Medical Entomology and Zoology · Cited by 769
Conceptualization and Measurement of Health for Adults in the Health Insurance Study
Stewart, A., Ware, J. E., Brook, R. H., & Davies, A. R. (1978) · Cited by 641
Lara, P. N., Higdon, R., Lim, N., Kwan, K., Tanaka, M., Lau, D. H. M., Wun, T., Welborn, J., Meyers, F. J., Christensen, S., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.6.1728 · Cited by 588
Cancer burden in the aged: an epidemiologic and demographic overview.
Yancik, R. (1997) · PubMed · Cited by 558
Cancer burden in the aged: An epidemiologic and demographic overview
Yancik, R. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19971001)80:7<1273::aid-cncr13>3.0.co;2-4 · Cited by 473
Representation of older patients in cancer treatment trials
Trimble, E. L., Cain, D., Ungerleider, R. S., Friedman, M. A., Carter, C. L., & Freidlin, B. (1994) · Cancer · doi:10.1002/1097-0142(19941001)74:7+<2208::aid-cncr2820741737>3.0.co;2-# · Cited by 343
Crivellari, D., Bonetti, M., Castiglione-Gertsch, M., Gelber, R. D., Rudenstam, C.-M., Thürlimann, B., Price, K. N., Coates, A. S., Hürny, C., Bernhard, J., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.7.1412 · Cited by 291
Tejeda, H. A., Green, S. B., Trimble, E. L., Ford, L., High, J. L., Ungerleider, R. S., Friedman, M. A., & Brawley, O. W. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.12.812 · Cited by 269
Cited by
Barriers to recruiting underrepresented populations to cancer clinical trials: a systematic review
Ford, J. G., Howerton, M. W., Lai, G. Y., Gary, T. L., Bolen, S., Gibbons, M. C., Tilburt, J., Baffi, C., Tanpitukpongse, T. P., Wilson, R. F., et al. (2008) · Cancer · doi:10.1002/cncr.23157 · Cited by 1,083
Talarico, L., Chen, G., & Pazdur, R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.02.175 · Cited by 727
The Role of Clinical Trial Participation in Cancer Research: Barriers, Evidence, and Strategies
Unger, J. M., Cook, E., Tai, E., & Bleyer, A. (2016) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_156686 · Cited by 665
Biganzoli, L., Wildiers, H., Oakman, C., Marotti, L., Loibl, S., Kunkler, I., Reed, M., Ciatto, S., Voogd, A. C., Brain, E., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70383-7 · Cited by 567
Adjuvant Chemotherapy in Older Women with Early-Stage Breast Cancer
Muss, H. B., Berry, D. A., Cirrincione, C. T., Theodoulou, M., Mauer, A. M., Kornblith, A. B., Partridge, A. H., Dressler, L. G., Cohen, H. J., Becker, H. P., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810266 · Cited by 554
Self-citation
Metadata
- Authors
- Kemeny, M. M., Peterson, B. L., Kornblith, A. B., Muss, H. B., Wheeler, J., Levine, E., Bartlett, N., Fleming, G., & Cohen, H. J.
- Venue
- Journal of Clinical Oncology
- Published
- 2003-06-15
- Volume
- 21
- Issue
- 12
- Pages
- 2268-2275
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1964543752
- Cited by
- 465
- References
- 22
- FWCI
- 22.75
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Barriers to Clinical Trial Participation by Older Women With Breast Cancer. https://app.cochat.ai/papers/10.1200/jco.2003.09.124
- The paper
- Kemeny, M. M., Peterson, B. L., Kornblith, A. B., Muss, H. B., Wheeler, J., Levine, E., Bartlett, N., Fleming, G., & Cohen, H. J. (2003). Barriers to Clinical Trial Participation by Older Women With Breast Cancer. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2003.09.124
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
