The DOI matches its Crossref record; 250 of the 250 references it cites were found in a registry or an index.
Herbal Remedies in the United States: Potential Adverse Interactions With Anticancer Agents
Abstract
Purpose: Interest in the use of herbal products has grown dramatically in the Western world. Recent estimates suggest an overall prevalence for herbal preparation use of 13% to 63% among cancer patients. With the narrow therapeutic range associated with most anticancer drugs, there is an increasing need for understanding possible adverse drug interactions in medical oncology. Methods: In this article, a literature overview is provided of known or suspected interactions of the 15 best-selling herbs in the United States with conventional allopathic therapies for cancer. Results: Herbs with the potential to significantly modulate the activity of drug-metabolizing enzymes (notably cytochrome P450 isozymes) and/or the drug transporter P-glycoprotein include garlic (Allium sativum), ginkgo (Ginkgo biloba), echinacea (Echinacea purpurea), ginseng (Panax ginseng), St John's wort (Hypericum perforatum), and kava (Piper methysticum). All of these products participate in potential pharmacokinetic interactions with anticancer drugs. Conclusion: It is suggested that health care professionals and consumers should be aware of the potential for adverse interactions with these herbs, question their patients on their use of them, especially among patients whose disease is not responding to treatments as expected, and urge patients to avoid herbs that could confound their cancer care.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Eisenberg, D. M., Davis, R. B., Ettner, S. L., Appel, S., Wilkey, S., Van Rompay, M., & Kessler, R. C. (1998) · JAMA · doi:10.1001/jama.280.18.1569 · Cited by 6,658
Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies
Lazarou, J., Pomeranz, B. H., & Corey, P. N. (1998) · JAMA · doi:10.1001/jama.279.15.1200 · Cited by 4,807
Why Patients Use Alternative Medicine: Results of a National Study
Astin, J. A. (1998) · JAMA · doi:10.1001/jama.279.19.1548 · Cited by 2,865
Kaufman, D. W., Kelly, J. P., Rosenberg, L., Anderson, T. E., & Mitchell, A. A. (2002) · JAMA · doi:10.1001/jama.287.3.337 · Cited by 1,845
Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T., & Kliewer, S. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3703 · Cited by 1,576
Schinkel, A. H., Wagenaar, E., van Deemter, L., Mol, C. A., & Borst, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118214 · Cited by 1,107
Quality of Life in Long-Term, Disease-Free Survivors of Breast Cancer: a Follow-up Study
Ganz, P. A. (2002) · CancerSpectrum Knowledge Environment · doi:10.1093/jnci/94.1.39 · Cited by 1,060
Richardson, M. A., Sanders, T., Palmer, J. L., Greisinger, A., & Singletary, S. E. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.13.2505 · Cited by 1,022
Genetic contribution to variable human CYP3A-mediated metabolism
Lamba, J. K., Lin, Y. S., Schuetz, E. G., & Thummel, K. E. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00066-2 · Cited by 990
Cited by
Ekor, M. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00177 · Cited by 3,919
de Man, F. M., Goey, A. K. L., van Schaik, R. H. N., Mathijssen, R. H. J., & Bins, S. (2018) · Clinical Pharmacokinetics · doi:10.1007/s40262-018-0644-7 · Cited by 421
Therapeutic Applications of Herbal Medicines for Cancer Patients
Yin, S.-Y., Wei, W.-C., Jian, F.-Y., & Yang, N.-S. (2013) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2013/302426 · Cited by 384
Johnson, S. B., Park, H. S., Gross, C. P., & Yu, J. B. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.2487 · Cited by 325
Exploring the Role of “Brahmi” (Bacopa monnieri and Centella asiatica) in Brain Function and Therapy
G.K., S., Muralidhara, & M.S. Bharath, M. (2011) · Recent Patents on Endocrine, Metabolic & Immune Drug Discovery · doi:10.2174/187221411794351833 · Cited by 131
Metadata
- Authors
- Sparreboom, A., Cox, M. C., Acharya, M. R., & Figg, W. D.
- Venue
- Journal of Clinical Oncology
- Published
- 2004-06-15
- Volume
- 22
- Issue
- 12
- Pages
- 2489-2503
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2041801408
- Cited by
- 473
- References
- 250
- FWCI
- 71.20
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Herbal Remedies in the United States: Potential Adverse Interactions With Anticancer Agents. https://app.cochat.ai/papers/10.1200/jco.2004.08.182
- The paper
- Sparreboom, A., Cox, M. C., Acharya, M. R., & Figg, W. D. (2004). Herbal Remedies in the United States: Potential Adverse Interactions With Anticancer Agents. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2004.08.182
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
