Hyperbaric Oxygen Therapy for Radionecrosis of the Jaw: A Randomized, Placebo-Controlled, Double-Blind Trial From the ORN96 Study Group
Abstract
Purpose: To determine the efficacy and safety of hyperbaric oxygen therapy (HBO) for overt mandibular osteoradionecrosis. Patients and Methods: This prospective, multicenter, randomized, double-blind, placebo-controlled trial was conducted at 12 university hospitals. Ambulatory adults with overt osteoradionecrosis of the mandible were assigned to receive 30 HBO exposures preoperatively at 2.4 absolute atmosphere for 90 minutes or a placebo, and 10 additional HBO dives postoperatively or a placebo. The main outcome measure was 1-year recovery rate from osteoradionecrosis. Secondary end points included time to treatment failure, time to pain relief, 1-year mortality rate, and treatment safety. Results: At the time of the second interim analysis, based on the triangular test, the study was stopped for potentially worse outcomes in the HBO arm. A total of 68 patients were enrolled and analyzed. At 1 year, six (19%) of 31 patients had recovered in the HBO arm and 12 (32%) of 37 in the placebo arm (relative risk = 0.60; 95% CI, 0.25 to 1.41; P = .23). Time to treatment failure (hazard ratio = 1.33; 95% CI, 0.68 to 2.60; P = .41) and time to pain relief (hazard ratio = 1.00; 95% CI, 0.52 to 1.89; P = .99) were similar between the two treatment arms. Conclusion: Patients with overt mandibular osteoradionecrosis did not benefit from hyperbaric oxygenation.
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In a trial, patients with pronounced osteoradionecrosis of the mandible did not benefit from HBO.
“The primary outcome measure was the 1‐year recovery rate from osteoradionecrosis, but the results showed that patients with pronounced osteoradionecrosis of the mandible did not benefit from HBO. 373”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [373]
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- Authors
- Annane, D., Depondt, J., Aubert, P., Villart, M., Géhanno, P., Gajdos, P., & Chevret, S.
- Affiliations
- Hôpital Raymond-Poincaré (FR)
- Venue
- Journal of Clinical Oncology
- Published
- 2004-12-15
- Volume
- 22
- Issue
- 24
- Pages
- 4893-4900
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2166297968
- Cited by
- 357
- References
- 22
- Citations by year
- 2026: 6 · 2025: 21 · 2024: 21 · 2023: 12 · 2022: 12 · 2021: 25 · 2020: 14 · 2019: 18 · 2018: 12 · 2017: 15 · 2016: 21 · 2015: 19 · 2014: 19 · 2013: 11 · 2012: 24
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Oral health in cancer treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- hyperbaric oxygen therapy, osteoradionecrosis of the jaw, mandible, radiotherapy complications, treatment failure, analgesia, treatment safety
- MeSH terms
- Double-Blind Method, Female, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Male, Mandibular Diseases, Middle Aged, Osteoradionecrosis, Placebos, Treatment Outcome
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