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Cited by 261

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Elevated Incidence of Lung Cancer Among HIV-Infected Individuals

Engels, Eric A., Brock, Malcolm V., Chen, Jinbo, Hooker, Craig M., Gillison, Maura, Moore, Richard D.·2006·Journal of Clinical Oncology
DOI 10.1200/jco.2005.03.4413
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Abstract

Purpose: People with HIV infection in the United States frequently smoke tobacco. We sought to characterize lung cancer incidence among HIV-infected individuals, examine whether cancer risk was related to HIV-induced immunosuppression, and assess whether the high prevalence of smoking explained elevated risk. Methods: We conducted a retrospective cohort study at an HIV specialty clinic in Baltimore, MD (1989-2003). Incident lung cancers were identified using hospital records. We used negative binomial regression to compare incidence across subgroups defined by demographics, use of highly active antiretroviral therapy (HAART), and HIV markers. Standardized incidence ratios (SIRs) compared incidence with an urban reference population (Detroit, MI). We adjusted SIRs for the effect of smoking, using smoking prevalences estimated from part of the cohort and the general population. 95% CIs and P values were two sided. Results: Thirty-three lung cancers were observed among 5,238 HIV-infected patients (incidence: 170 per 100,000 person-years). Incidence increased with age (P < .0001), but did not differ by sex, race, or CD4 count. Incidence tended to increase with calendar year (P = .09) and HAART use (P = .10), and was inversely related to HIV viral load (P = .03), but these associations were attenuated with age adjustment. The SIR was 4.7 (95% CI, 3.2 to 6.5) versus the general population. Twenty-eight lung cancer patients (85%) and 69% of the cohort were smokers. After smoking adjustment, risk remained elevated (SIR, 2.5; 95% CI, 1.6 to 3.5). Conclusion: Lung cancer risk was substantially elevated in HIV-infected individuals. Incidence was unrelated to HIV-induced immunosuppression. Notably, incidence remained high after adjustment for smoking, suggesting the involvement of additional factors.

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Metadata

Authors
Engels, E. A., Brock, M. V., Chen, J., Hooker, C. M., Gillison, M., & Moore, R. D.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2006-03-20
Volume
24
Issue
9
Pages
1383-1388
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2005.03.4413
OpenAlex
W2029527133
Cited by
261
References
25
FWCI
6.82
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Elevated Incidence of Lung Cancer Among HIV-Infected Individuals. https://app.cochat.ai/papers/10.1200/jco.2005.03.4413
The paper
Engels, E. A., Brock, M. V., Chen, J., Hooker, C. M., Gillison, M., & Moore, R. D. (2006). Elevated Incidence of Lung Cancer Among HIV-Infected Individuals. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2005.03.4413

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.