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Cited by 868

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Swedish Rectal Cancer Trial: Long Lasting Benefits From Radiotherapy on Survival and Local Recurrence Rate

Open access
Folkesson, Joakim, Birgisson, Helgi, Pahlman, Lars, Cedermark, Bjorn, Glimelius, Bengt, Gunnarsson, Ulf·2005·Journal of Clinical Oncology

Abstract

Purpose: To evaluate the long-term effects on survival and recurrence rates of preoperative radiotherapy in the treatment of curatively operated rectal cancer patients. Patients and Methods: Of 1,168 randomly assigned patients in the Swedish Rectal Cancer Trial between 1987 and 1990, 908 had curative surgery; 454 of these patients had surgery alone, and 454 were administered preoperative radiotherapy (25 Gy in 5 days) followed by surgery within 1 week. Follow-up was performed by matching against three Swedish nationwide registries (the Swedish Cancer Register, the Hospital Discharge Register, and the Cause of Death Register). Results: Median follow-up time was 13 years (range, 3 to 15 years). The overall survival rate in the irradiated group was 38% v 30% in the nonirradiated group (P = .008). The cancer-specific survival rate in the irradiated group was 72% v 62% in the nonirradiated group (P = .03), and the local recurrence rate was 9% v 26% (P < .001), respectively. The reduction of local recurrence rates was observed at all tumor heights, although it was not statistically significant for tumors greater than 10 cm from the anal verge. Conclusion: Preoperative radiotherapy with 25 Gy in 1 week before curative surgery for rectal cancer is beneficial for overall and cancer-specific survival and local recurrence rates after long-term follow-up.

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Metadata

Authors
Folkesson, J., Birgisson, H., Pahlman, L., Cedermark, B., Glimelius, B., & Gunnarsson, U.
Venue
Journal of Clinical Oncology
Published
2005-08-20
Volume
23
Issue
24
Pages
5644-5650
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
OpenAlex
W2156074757
Cited by
868
References
3
FWCI
12.86
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Swedish Rectal Cancer Trial: Long Lasting Benefits From Radiotherapy on Survival and Local Recurrence Rate. https://app.cochat.ai/papers/10.1200/jco.2005.08.144
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Folkesson, J., Birgisson, H., Pahlman, L., Cedermark, B., Glimelius, B., & Gunnarsson, U. (2005). Swedish Rectal Cancer Trial: Long Lasting Benefits From Radiotherapy on Survival and Local Recurrence Rate. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2005.08.144

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