The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Chemoselection As a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated With HPV16 Copy Number
Open accessAbstract
Purpose: To test induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CRT) or surgery/radiotherapy (RT) for advanced oropharyngeal cancer and to assess the effect of human papilloma virus (HPV) on response and outcome. Patients and Methods: Sixty-six patients (51 male; 15 female) with stage III to IV squamous cell carcinoma of the oropharynx (SCCOP) were treated with one cycle of cisplatin (100 mg/m 2) or carboplatin (AUC 6) and with fluorouracil (1,000 mg/m 2/d for 5 days) to select candidates for CRT. Those achieving a greater than 50% response at the primary tumor received CRT (70 Gy; 35 fractions with concurrent cisplatin 100 mg/m 2 or carboplatin (AUC 6) every 21 days for three cycles). Adjuvant paclitaxel was given to patients who were complete histologic responders. Patients with a response of 50% or less underwent definitive surgery and postoperative radiation. Pretreatment biopsies from 42 patients were tested for high-risk HPV. Results: Fifty-four of 66 patients (81%) had a greater than 50% response after IC. Of these, 53 (98%) received CRT, and 49 (92%) obtained complete histologic response with a 73.4% (47 of 64) rate of organ preservation. The 4-year overall survival (OS) was 70.4%, and the disease-specific survival (DSS) was 75.8% (median follow-up, 64.1 months). HPV16, found in 27 of 42 (64.3%) biopsies, was associated with younger age (median, 55 v 63 years; P = .016), sex (22 of 30 males [73.3%] and five of 12 females [41.7%]; P = .08), and nonsmoking status (P = .037). HPV titer was significantly associated with IC response (P = .001), CRT response (P = .005), OS (P = .007), and DSS (P = .008). Conclusion: Although the numbers in this study are small, IC followed by CRT is an effective treatment for SCCOP, especially in patients with HPV-positive tumors; however, for patients who do not respond to treatment, alternative treatments must be developed.
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Cited by
Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer
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Metadata
- Authors
- Worden, F. P., Kumar, B., Lee, J. S., Wolf, G. T., Cordell, K. G., Taylor, J. M. G., Urba, S. G., Eisbruch, A., Teknos, T. N., Chepeha, D. B., Prince, M. E., Tsien, C. I., D’Silva, N. J., Yang, K., Kurnit, D. M., Mason, H. L., Miller, T. H., Wallace, N. E., Bradford, C. R., & Carey, T. E.
- Venue
- Journal of Clinical Oncology
- Published
- 2008-07-01
- Volume
- 26
- Issue
- 19
- Pages
- 3138-3146
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2122035130
- Cited by
- 357
- References
- 33
- FWCI
- 29.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Worden, F. P., Kumar, B., Lee, J. S., Wolf, G. T., Cordell, K. G., Taylor, J. M. G., Urba, S. G., Eisbruch, A., Teknos, T. N., Chepeha, D. B., Prince, M. E., Tsien, C. I., D’Silva, N. J., Yang, K., Kurnit, D. M., Mason, H. L., Miller, T. H., Wallace, N. E., Bradford, C. R., & Carey, T. E. (2008). Chemoselection As a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated With HPV16 Copy Number. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2007.12.7597
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
