The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Complete Pathologic Response After Preoperative Chemotherapy for Colorectal Liver Metastases: Myth or Reality?
Abstract
Purpose: Complete clinical response (CCR) of colorectal liver metastases (CLM) following chemotherapy is of limited predictive value for complete pathologic response (CPR) and cure of the disease. The objective of this study was to determine predictive factors of CPR as well as its impact on survival. Patients and Methods: From January 1985 to July 2006, 767 consecutive patients with CLM underwent liver resection after systemic chemotherapy. Patients with CPR were compared with patients without CPR. Results: Twenty-nine of 767 (4%) patients had CPR, and none of these 29 patients had CCR. Patients with CPR (mean age, 54 years) had a mean number of 3.3 metastases at diagnosis (mean size, 29.3 mm). Objective response and stable disease were observed in 79% and 21% of cases, respectively. Postoperative mortality rate was 0%. After a median follow-up of 52.2 months (range, 1.1 to 193.0 months), overall 5-year survival was 76% for patients with CPR compared with 45% for patients without CPR (P = .004). Independent predictive factors for CPR were: age ≤ 60 years, size of metastases ≤ 3 cm at diagnosis, carcinoembryonic antigen (CEA) level at diagnosis ≤ 30 ng/mL, and objective response following chemotherapy. The probability of CPR ranged from 0.2% when all factors were absent to 30.9% when all were present. Conclusion: CPR was observed in 4% of patients with CLM treated with preoperative chemotherapy. However, CPR may occur in almost one-third of objective responders age ≤ 60 years with metastases ≤ 3 cm and low CEA values. CPR is associated with uncommon high survival rates.
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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
New Guidelines to Evaluate the Response to Treatment in Solid Tumors
Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660
Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Baron, A., Griffing, S., Holmgren, E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032691 · Cited by 10,968
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Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer
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Covariance Analysis of Censored Survival Data
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Resection of colorectal liver metastases
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Adam, R., Delvart, V., Pascal, G., Valeanu, A., Castaing, D., Azoulay, D., Giacchetti, S., Paule, B., Kunstlinger, F., Ghémard, O., et al. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000141198.92114.f6 · Cited by 1,480
Self-citationLiver resection for colorectal metastases.
Fong, Y., Cohen, A. M., Fortner, J. G., Enker, W. E., Turnbull, A. D., Coit, D. G., Marrero, A. M., Prasad, M., Blumgart, L. H., & Brennan, M. F. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.3.938 · Cited by 1,284
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Cited by
Japanese Society for Cancer of the Colon and Rectum, Watanabe, T., Muro, K., Ajioka, Y., Hashiguchi, Y., Ito, Y., Saito, Y., Hamaguchi, T., Ishida, H., Ishiguro, M., et al. (2018) · International Journal of Clinical Oncology · doi:10.1007/s10147-017-1101-6 · Cited by 2,467
Hashiguchi, Y., Muro, K., Saito, Y., Ito, Y., Ajioka, Y., Hamaguchi, T., Hasegawa, K., Hotta, K., Ishida, H., Ishiguro, M., et al. (2020) · International Journal of Clinical Oncology · doi:10.1007/s10147-019-01485-z · Cited by 1,922
Kemeny, N. E., Melendez, F. D. H., Capanu, M., Paty, P. B., Fong, Y., Schwartz, L. H., Jarnagin, W. R., Patel, D., & D'Angelica, M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.1301 · Cited by 313
Allard, M.-A., Sebagh, M., Ruiz, A., Guettier, C., Paule, B., Vibert, E., Cunha, A. S., Cherqui, D., Samuel, D., Bismuth, H., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.01.023 · Cited by 137
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Metadata
- Authors
- Adam, R., Wicherts, D. A., de Haas, R. J., Aloia, T., Lévi, F., Paule, B., Guettier, C., Kunstlinger, F., Delvart, V., Azoulay, D., & Castaing, D.
- Venue
- Journal of Clinical Oncology
- Published
- 2008-04-01
- Volume
- 26
- Issue
- 10
- Pages
- 1635-1641
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2144727645
- Cited by
- 300
- References
- 24
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Adam, R., Wicherts, D. A., de Haas, R. J., Aloia, T., Lévi, F., Paule, B., Guettier, C., Kunstlinger, F., Delvart, V., Azoulay, D., & Castaing, D. (2008). Complete Pathologic Response After Preoperative Chemotherapy for Colorectal Liver Metastases: Myth or Reality? Journal of Clinical Oncology. https://doi.org/10.1200/jco.2007.13.7471
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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