The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Cancer Care Ontario and American Society of Clinical Oncology Adjuvant Chemotherapy and Adjuvant Radiation Therapy for Stages I-IIIA Resectable Non–Small-Cell Lung Cancer Guideline
Abstract
Purpose: To determine the role of adjuvant chemotherapy and radiation therapy in patients with completely resected stage IA-IIIA non–small-cell lung cancer (NSCLC). Methods: The Cancer Care Ontario Program in Evidence-Based Care and the American Society of Clinical Oncology convened a Joint Expert Panel in August 2006 to review the evidence and draft recommendations for these therapies. Results: Available data support the use of adjuvant cisplatin-based chemotherapy in completely resected NSCLC; however, the strength of the data and consequent recommendations vary by disease stage. Adjuvant radiation therapy appears detrimental to survival in stages IB and II, with a possible modest benefit in stage IIIA. Conclusion: Adjuvant cisplatin-based chemotherapy is recommended for routine use in patients with stages IIA, IIB, and IIIA disease. Although there has been a statistically significant overall survival benefit seen in several randomized clinical trials (RCTs) enrolling a range of people with completely resected NSCLC, results of subset analyses for patient populations with stage IB disease were not significant, and adjuvant chemotherapy in stage IB disease is not currently recommended for routine use. To date, very few patients with stage IA NSCLC have been enrolled onto RCTs of adjuvant therapy; adjuvant chemotherapy is not recommended in these cases. Evidence from RCTs demonstrates a survival detriment for adjuvant radiotherapy with limited evidence for a reduction in local recurrence. Adjuvant radiation therapy appears detrimental to survival in stage IB and II, and may possibly confer a modest benefit in stage IIIA.
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Power and sample size calculations
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Vinorelbine plus Cisplatin vs. Observation in Resected Non–Small-Cell Lung Cancer
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Self-citationDNA Repair by ERCC1 in Non–Small-Cell Lung Cancer and Cisplatin-Based Adjuvant Chemotherapy
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Cited by
Non-small cell lung cancer: current treatment and future advances
Zappa, C., & Mousa, S. A. (2016) · Translational Lung Cancer Research · doi:10.21037/tlcr.2016.06.07 · Cited by 1,944
Azzoli, C. G., Baker, S., Temin, S., Pao, W., Aliff, T., Brahmer, J., Johnson, D. H., Laskin, J. L., Masters, G., Milton, D., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.5622 · Cited by 915
Self-citationSarraf, K. M., Belcher, E., Raevsky, E., Nicholson, A. G., Goldstraw, P., & Lim, E. (2009) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.05.046 · Cited by 555
Metadata
- Authors
- Pisters, K. M. W., Evans, W. K., Azzoli, C. G., Kris, M. G., Smith, C. A., Desch, C. E., Somerfield, M. R., Brouwers, M. C., Darling, G., Ellis, P. M., Gaspar, L. E., Pass, H. I., Spigel, D. R., Strawn, J. R., Ung, Y. C., & Shepherd, F. A.
- Venue
- Journal of Clinical Oncology
- Published
- 2007-12-01
- Volume
- 25
- Issue
- 34
- Pages
- 5506-5518
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2168150041
- Cited by
- 363
- References
- 44
- FWCI
- 21.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Pisters, K. M. W., Evans, W. K., Azzoli, C. G., Kris, M. G., Smith, C. A., Desch, C. E., Somerfield, M. R., Brouwers, M. C., Darling, G., Ellis, P. M., Gaspar, L. E., Pass, H. I., Spigel, D. R., Strawn, J. R., Ung, Y. C., & Shepherd, F. A. (2007). Cancer Care Ontario and American Society of Clinical Oncology Adjuvant Chemotherapy and Adjuvant Radiation Therapy for Stages I-IIIA Resectable Non–Small-Cell Lung Cancer Guideline. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2007.14.1226
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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