The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Impact of Late Treatment-Related Toxicity on Quality of Life Among Patients With Head and Neck Cancer Treated With Radiotherapy
Abstract
Purpose: To investigate the impact of treatment-related toxicity on health-related quality of life (HRQoL) among patients with head and neck squamous cell carcinoma treated with radiotherapy either alone or in combination with chemotherapy or surgery. Patients and Methods: The study sample was composed of 425 disease-free patients. Toxicity was scored according to the European Organisation for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) late radiation-induced morbidity scoring system. HRQoL was assessed using the EORTC Quality of Life Questionnaire C30. These assessments took place at 6, 12, 18, and 24 months after completion of radiotherapy. The analysis was performed using a multivariate analysis of variance. Results: Of the six RTOG scales investigated, two significantly affected self-reported HRQoL, salivary gland (RTOG xerostomia) and esophagus/pharynx (RTOG swallowing). Although RTOG xerostomia was reported most frequently, HRQoL was most affected by RTOG swallowing, particularly in the first 18 months after completion of radiotherapy. Conclusion: Late radiation-induced toxicity, particularly RTOG swallowing and RTOG xerostomia, has a significant impact on the more general dimensions of HRQoL. These findings suggest that the development of new radiation-induced delivery techniques should not only focus on reduction of the dose to the salivary glands, but also on anatomic structures that are involved in swallowing.
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Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer
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Late effects toxicity scoring: the SOMA scale
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Pretreatment, Preoperative Swallowing Exercises May Improve Dysphagia Quality of Life
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Cited by
Langendijk, J. A., Lambin, P., De Ruysscher, D., Widder, J., Bos, M., & Verheij, M. (2013) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.05.007 · Cited by 549
Self-citationHead and Neck Cancers, Version 2.2014
Pfister, D. G., Spencer, S., Brizel, D. M., Burtness, B., Busse, P. M., Caudell, J. J., Cmelak, A. J., Colevas, A. D., Dunphy, F., Eisele, D. W., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0142 · Cited by 283
Badr, H., Lipnick, D., Diefenbach, M. A., Posner, M., Kotz, T., Miles, B., & Genden, E. (2016) · European Journal of Cancer Care · doi:10.1111/ecc.12396 · Cited by 55
Leong Abdullah, M. F. I., Nik Jaafar, N. R., Zakaria, H., Rajandram, R. K., Mahadevan, R., Mohamad Yunus, M. R., & Shah, S. A. (2015) · Psycho-Oncology · doi:10.1002/pon.3740 · Cited by 44
Metadata
- Authors
- Langendijk, J. A., Doornaert, P., Verdonck-de Leeuw, I. M., Leemans, C. R., Aaronson, N. K., & Slotman, B. J.
- Venue
- Journal of Clinical Oncology
- Published
- 2008-08-01
- Volume
- 26
- Issue
- 22
- Pages
- 3770-3776
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2118772763
- Cited by
- 696
- References
- 17
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Impact of Late Treatment-Related Toxicity on Quality of Life Among Patients With Head and Neck Cancer Treated With Radiotherapy. https://app.cochat.ai/papers/10.1200/jco.2007.14.6647
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- Langendijk, J. A., Doornaert, P., Verdonck-de Leeuw, I. M., Leemans, C. R., Aaronson, N. K., & Slotman, B. J. (2008). Impact of Late Treatment-Related Toxicity on Quality of Life Among Patients With Head and Neck Cancer Treated With Radiotherapy. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2007.14.6647
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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