The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Palliative Thoracic Radiotherapy for Lung Cancer: A Systematic Review
Abstract
Purpose: The optimal dose of radiotherapy (RT) to palliate symptomatic advanced lung cancer is unclear. We systematically reviewed randomized controlled trials (RCTs) of palliative thoracic RT. Methods: RCTs comparing two or more dose fractionation schedules were reviewed using the random-effects model of a freely available information management system. The relative risk and 95% CI for each outcome were presented in Forrest plots. Exploratory analysis comparing dose schedules after conversion to the time-adjusted biologically equivalent dose (BED) was performed to investigate for a dose-response relationship. Results: A total of 13 RCTs involving 3,473 randomly assigned patients were identified. Outcomes included symptom palliation, overall survival, toxicity, and reirradiation rate. For symptom control in assessable patients, lower-dose (LD) RT was comparable with higher-dose (HD), except for the total symptom score (TSS): 65.4% of LD and 77.1% of HD patients had improved TSS (P = .003). Greater likelihood of symptom improvement was seen with schedules of 35 Gy 10 versus lower BED. At 1 year after HD and LD RT, 26.5% versus 21.7% of patients were alive, respectively (P = .002). Sensitivity analysis suggests this survival improvement was seen with 35 Gy 10 BED schedules compared with LDs. Physician-assessed dysphagia was significantly greater in the HD arm (20.5% v 14.9%; P = .01), and the likelihood of reirradiation was 1.2-fold higher after LD RT. Conclusion: No significant differences were observed for specific symptom-control end points, although improvement in survival favored HD RT. Consideration of palliative thoracic RT of at least 35 Gy 10 BED may therefore be warranted, but must be weighed against increased toxicity and greater time investment.
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Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Wu, J. S.-Y., Wong, R., Johnston, M., Bezjak, A., & Whelan, T. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04147-0 · Cited by 601
Self-citation(1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.8.2996 · Cited by 355
Chow, E., Wu, J. S. Y., Hoskin, P., Coia, L. R., Bentzen, S. M., & Blitzer, P. H. (2002) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(02)00170-6 · Cited by 314
Self-citationMedical Research Council Lung Cancer Working Party*, Bleehen, N., Girling, D., Machin, D., & Stephens, R. (1992) · British Journal of Cancer · doi:10.1038/bjc.1992.196 · Cited by 274
Medical Research Council Lung Cancer Working Party, Macbeth, F. R., Bolger, J. J., Hopwood, P., Bleehen, N. M., Cartmell, J., Girling, D. J., Machin, D., Stephens, R. J., & Bailey, A. J. (1996) · Clinical Oncology · doi:10.1016/s0936-6555(96)80041-0 · Cited by 228
Sundstrøm, S., Bremnes, R., Aasebø, U., Aamdal, S., Hatlevoll, R., Brunsvig, P., Johannessen, D. C., Klepp, O., Fayers, P. M., & Kaasa, S. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.06.123 · Cited by 175
Radiotherapy for palliation of symptoms in incurable cancer
Hoegler, D. (1997) · Current Problems in Cancer · doi:10.1016/s0147-0272(97)80004-9 · Cited by 171
Bezjak, A., Dixon, P., Brundage, M., Tu, D. S., Palmer, M. J., Blood, P., Grafton, C., Lochrin, C., Leong, C., Mulroy, L., et al. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)02989-9 · Cited by 168
Self-citationQuality of life after palliative radiotherapy in non-small cell lung cancer: a prospective study
Langendijk, J. A., ten Velde, G. P. M., Aaronson, N. K., Jong, J. M. A. D., Muller, M. J., & Wouters, E. F. �. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00540-4 · Cited by 155
Cited by
Dechartres, A., Boutron, I., Trinquart, L., Charles, P., & Ravaud, P. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-1-201107050-00006 · Cited by 307
Konstantinidou, G., Bey, E. A., Rabellino, A., Schuster, K., Maira, M. S., Gazdar, A. F., Amici, A., Boothman, D. A., & Scaglioni, P. P. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0823 · Cited by 142
Tang, K.-J., Constanzo, J. D., Venkateswaran, N., Melegari, M., Ilcheva, M., Morales, J. C., Skoulidis, F., Heymach, J. V., Boothman, D. A., & Scaglioni, P. P. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2603 · Cited by 91
Lee, J. Y., Sun, J.-M., Lim, S. H., Kim, H. S., Yoo, K. H., Jung, K. S., Song, H.-N., Ku, B. M., Koh, J., Bae, Y.-H., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1653 · Cited by 36
“confirmed the minimal toxicity of nimotuzumab in combination with thoracic radiation, and also demonstrated favorable results compared with historical controls in a NSCLC (25-27).”
Result
Metadata
- Authors
- Fairchild, A., Harris, K., Barnes, E., Wong, R., Lutz, S., Bezjak, A., Cheung, P., & Chow, E.
- Venue
- Journal of Clinical Oncology
- Published
- 2008-08-20
- Volume
- 26
- Issue
- 24
- Pages
- 4001-4011
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1990811913
- Cited by
- 270
- References
- 14
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fairchild, A., Harris, K., Barnes, E., Wong, R., Lutz, S., Bezjak, A., Cheung, P., & Chow, E. (2008). Palliative Thoracic Radiotherapy for Lung Cancer: A Systematic Review. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2007.15.3312
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
