The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Monosomal Karyotype in Acute Myeloid Leukemia: A Better Indicator of Poor Prognosis Than a Complex Karyotype
Open accessAbstract
Purpose: To investigate the prognostic value of various cytogenetic components of a complex karyotype in acute myeloid leukemia (AML). Patients and Methods: Cytogenetics and overall survival (OS) were analyzed in 1,975 AML patients age 15 to 60 years. Results: Besides AML with normal cytogenetics (CN) and core binding factor (CBF) abnormalities, we distinguished 733 patients with cytogenetic abnormalities. Among the latter subgroup, loss of a single chromosome (n = 109) conferred negative prognostic impact (4-year OS, 12%; poor outcome). Loss of chromosome 7 was most common, but outcome of AML patients with single monosomy −7 (n = 63; 4-year OS, 13%) and other single autosomal monosomies (n = 46; 4-year OS, 12%) did not differ. Structural chromosomal abnormalities influenced prognosis only in association with a single autosomal monosomy (4-year OS, 4% for very poor v 24% for poor). We derived a monosomal karyotype (MK) as a predictor for very poor prognosis of AML that refers to two or more distinct autosomal chromosome monosomies (n = 116; 4-year OS, 3%) or one single autosomal monosomy in the presence of structural abnormalities (n = 68; 4-year OS, 4%). In direct comparisons, MK provides significantly better prognostic prediction than the traditionally defined complex karyotype, which considers any three or more or five or more clonal cytogenetic abnormalities, and also than various individual specific cytogenetic abnormalities (eg, del[5q], inv[3]/t[3;3]) associated with very poor outcome. Conclusion: MK enables (in addition to CN and CBF) the prognostic classification of two new aggregates of cytogenetically abnormal AML, the unfavorable risk MK-negative category (4-year OS, 26% ± 2%) and the highly unfavorable risk MK-positive category (4-year OS, 4% ± 1%).
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Cites
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Cytogenetics in acute leukemia
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Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078
Genomic classification and prognosis in acute myeloid leukemia
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Kayser, S., Döhner, K., Krauter, J., Köhne, C.-H., Horst, H. A., Held, G., von Lilienfeld-Toal, M., Wilhelm, S., Kündgen, A., Götze, K., et al. (2011) · Blood · doi:10.1182/blood-2010-08-301713 · Cited by 487
Metadata
- Authors
- Breems, D. A., Van Putten, W. L. J., De Greef, G. E., Van Zelderen-Bhola, S. L., Gerssen-Schoorl, K. B. J., Mellink, C. H. M., Nieuwint, A., Jotterand, M., Hagemeijer, A., Beverloo, H. B., & Löwenberg, B.
- Venue
- Journal of Clinical Oncology
- Published
- 2008-10-10
- Volume
- 26
- Issue
- 29
- Pages
- 4791-4797
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2117446917
- Cited by
- 580
- References
- 13
- FWCI
- 20.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Breems, D. A., Van Putten, W. L. J., De Greef, G. E., Van Zelderen-Bhola, S. L., Gerssen-Schoorl, K. B. J., Mellink, C. H. M., Nieuwint, A., Jotterand, M., Hagemeijer, A., Beverloo, H. B., & Löwenberg, B. (2008). Monosomal Karyotype in Acute Myeloid Leukemia: A Better Indicator of Poor Prognosis Than a Complex Karyotype. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2008.16.0259
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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