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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

Open access
Baccarani, Michele, Cortes, Jorge, Pane, Fabrizio, Niederwieser, Dietger, Saglio, Giuseppe, Apperley, Jane, Cervantes, Francisco, Deininger, Michael, Gratwohl, Alois, Guilhot, François, Hochhaus, Andreas, Horowitz, Mary, Hughes, Timothy, Kantarjian, Hagop, Larson, Richard, Radich, Jerald, Simonsson, Bengt, Silver, Richard T., Goldman, John, Hehlmann, Rudiger·2009·Journal of Clinical Oncology

Abstract

Purpose: To review and update the European LeukemiaNet (ELN) recommendations for the management of chronic myeloid leukemia with imatinib and second-generation tyrosine kinase inhibitors (TKIs), including monitoring, response definition, and first- and second-line therapy. Methods: These recommendations are based on a critical and comprehensive review of the relevant papers up to February 2009 and the results of four consensus conferences held by the panel of experts appointed by ELN in 2008. Results: Cytogenetic monitoring was required at 3, 6, 12, and 18 months. Molecular monitoring was required every 3 months. On the basis of the degree and the timing of hematologic, cytogenetic, and molecular results, the response to first-line imatinib was defined as optimal, suboptimal, or failure, and the response to second-generation TKIs was defined as suboptimal or failure. Conclusion: Initial treatment was confirmed as imatinib 400 mg daily. Imatinib should be continued indefinitely in optimal responders. Suboptimal responders may continue on imatinb, at the same or higher dose, or may be eligible for investigational therapy with second-generation TKIs. In instances of imatinib failure, second-generation TKIs are recommended, followed by allogeneic hematopoietic stem-cell transplantation only in instances of failure and, sometimes, suboptimal response, depending on transplantation risk.

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Metadata

Authors
Baccarani, M., Cortes, J., Pane, F., Niederwieser, D., Saglio, G., Apperley, J., Cervantes, F., Deininger, M., Gratwohl, A., Guilhot, F., Hochhaus, A., Horowitz, M., Hughes, T., Kantarjian, H., Larson, R., Radich, J., Simonsson, B., Silver, R. T., Goldman, J., & Hehlmann, R.
Venue
Journal of Clinical Oncology
Published
2009-12-10
Volume
27
Issue
35
Pages
6041-6051
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
OpenAlex
W2166654361
Cited by
1,291
References
6
FWCI
92.71
Type
journal article
Language
en
Open access
green

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The paper
Baccarani, M., Cortes, J., Pane, F., Niederwieser, D., Saglio, G., Apperley, J., Cervantes, F., Deininger, M., Gratwohl, A., Guilhot, F., Hochhaus, A., Horowitz, M., Hughes, T., Kantarjian, H., Larson, R., Radich, J., Simonsson, B., Silver, R. T., Goldman, J., & Hehlmann, R. (2009). Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2009.25.0779

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.