Molecular signature of CD34+ hematopoietic stem and progenitor cells of patients with CML in chronic phase

In silico prediction of protein-protein interactions in human macrophages

Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785 · see citing works

Significance analysis of microarrays applied to the ionizing radiation response

Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568 · see citing works

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

Brazma, A., Hingamp, P., Quackenbush, J., Sherlock, G., Spellman, P., Stoeckert, C., Aach, J., Ansorge, W., Ball, C. A., Causton, H. C., et al. (2001) · Nature Genetics · doi:10.1038/ng1201-365 · Cited by 4,109 · see citing works

Variance stabilization applied to microarray data calibration and to the quantification of differential expression

Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A., & Vingron, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.suppl_1.s96 · Cited by 2,440 · see citing works

Induction of Chronic Myelogenous Leukemia in Mice by the P210 bcr/abl Gene of the Philadelphia Chromosome

Daley, G. Q., Etten, R. A. V., & Baltimore, D. (1990) · Science · doi:10.1126/science.2406902 · Cited by 2,141 · see citing works

The molecular biology of chronic myeloid leukemia

Deininger, M. W., Goldman, J. M., & Melo, J. V. (2000) · Blood · doi:10.1182/blood.v96.10.3343 · Cited by 1,654 · see citing works

The Biology of Chronic Myeloid Leukemia

Faderl, S. H., Talpaz, M., Estrov, Z. E., O'Brien, S. M., Kurzrock, R., & Kantarjian, H. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907153410306 · Cited by 1,296 · see citing works

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

Tapon, N. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80156-1 · Cited by 819 · see citing works

Intracellular signalling pathways activated by leptin.

Frühbeck, G. (2006) · Biochemical Journal · doi:10.1042/bj20051578 · Cited by 805 · see citing works

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

Gainsford, T., Willson, T. A., Metcalf, D., Handman, E., McFarlane, C., Ng, A. P., Nicola, N. A., Alexander, W. S., & Hilton, D. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14564 · Cited by 750 · see citing works

Intracellular signalling pathways activated by leptin

Frühbeck, G. (. (2006) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · Cited by 745 · see citing works

BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571

Donato, N. J., Wu, J. Y., Stapley, J., Gallick, G. E., Lin, H., Arlinghaus, R. B., & Talpaz, M. (2002) · Blood · doi:10.1182/blood.v101.2.690 · Cited by 663 · see citing works

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644 · see citing works

Gene expression changes associated with progression and response in chronic myeloid leukemia

Radich, J. P., Dai, H., Mao, M., Oehler, V., Schelter, J., Druker, B., Sawyers, C., Shah, N., Stock, W., Willman, C. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510423103 · Cited by 583 · see citing works

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway

Skorski, T., Bellacosa, A., Nieborowska‐Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6151 · Cited by 567 · see citing works

Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity

Storms, R. W., Sindram-Trujillo, A. P., Springer, J. B., Shah, L., Colvin, O. M., Ludeman, S. M., & Smith, C. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9118 · Cited by 552 · see citing works

Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

Bhatia, R., Holtz, M. S., Niu, N., Gray, R., Snyder, D., Sawyers, C. L., Arber, D. A., Slovak, M. L., & Forman, S. J. (2003) · Blood · doi:10.1182/blood-2002-09-2780 · Cited by 543 · see citing works

Prospective isolation of human clonogenic common myeloid progenitors

Manz, M. G., Miyamoto, T., Akashi, K., & Weissman, I. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172384399 · Cited by 529 · see citing works

The hematopoietic stem cell in its place

Adams, G. B., & Scadden, D. T. (2006) · Nature Immunology · doi:10.1038/ni1331 · Cited by 450 · see citing works

Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia

Gordon, M. Y., Dowding, C., Riley, G. P., Goldman, J. M., & Greaves, M. F. (1987) · Nature · doi:10.1038/328342a0 · Cited by 436 · see citing works

A Coiled-Coil Oligomerization Domain of Bcr Is Essential for the Transforming Function of Bcr-Abl Oncoproteins

McWhirter, J. R., Galasso, D. L., & Wang, J. Y. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7587 · Cited by 422 · see citing works

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

Skórski, T., Kanakaraj, P., Nieborowska-Skorska, M., Ratajczak, M. Z., Wen, S. C., Zon, G., Gewirtz, A., PERUSSIA, B., & Calabretta, B. (1995) · Blood · doi:10.1182/blood.v86.2.726.bloodjournal862726 · Cited by 403 · see citing works

Dominant negative MYC blocks transformation by ABL oncogenes

Sawyers, C. L., Callahan, W., & Witte, O. N. (1992) · Cell · doi:10.1016/0092-8674(92)90241-4 · Cited by 395 · see citing works

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

Raitano, A., Halpern, J., Hambuch, T. M., & Sawyers, C. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11746 · Cited by 394 · see citing works

Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL

Horita, M., Andreu, E. J., Benito, A., Arbona, C., Sanz, C., Benet, I., Prósper, F., & Fernández-Luna, J. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.6.977 · Cited by 366 · see citing works

Hematopoietic cytokines, transcription factors and lineage commitment

Zhu, J., & Emerson, S. G. (2002) · Oncogene · doi:10.1038/sj.onc.1205318 · Cited by 327 · see citing works

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

Pineault, N., Helgason, C. D., Lawrence, H. J., & Humphries, R. K. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00757-3 · Cited by 282 · see citing works

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines.

Pizer, E. S., Chrest, F. J., DiGiuseppe, J. A., & Han, W. F. (1998) · PubMed · Cited by 250 · see citing works

STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells

Sillaber, C., Gesbert, F., Frank, D. A., Sattler, M., & Griffin, J. D. (2000) · Blood · doi:10.1182/blood.v95.6.2118 · Cited by 222 · see citing works

The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells

Cortez, D., Reuther, G. W., & Pendergast, A. M. (1997) · Oncogene · doi:10.1038/sj.onc.1201400 · Cited by 221 · see citing works

A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation

Notari, M., Neviani, P., Santhanam, R., Blaser, B. W., Chang, J.-S., Galietta, A., Willis, A. E., Roy, D., Caligiuri, M. A., Marcucci, G., et al. (2005) · Blood · doi:10.1182/blood-2005-09-3732 · Cited by 202 · see citing works

Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities

Konopleva, M. Y., Mikhail, A. A., Estrov, Z. E., Zhao, S., Harris, D., Sanchez‐Williams, G., Kornblau, S. M., Dong, J., Kliche, K. O., Jiang, S., et al. (1999) · Blood · doi:10.1182/blood.v93.5.1668 · Cited by 187 · see citing works

Transforming growth factor inhibits erythropoiesis by blocking proliferation and accelerating differentiation of erythroid progenitors

Zermati, Y., Fichelson, S., Valensi, F., Freyssinier, J. M., Rouyer‐Fessard, P., Cramer, E. M., Guichard, J., Varet, B. R., & Hermine, O. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00488-4 · Cited by 179 · see citing works

Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow–derived and circulating human CD34+ hematopoietic stem cells

Steidl, U. U., Kronenwett, R., Rohr, U., Fenk, R. R., Kliszewski, S., Maercker, C., Neubert, P., Aivado, M. A., Koch, J., Modlich, O., et al. (2002) · Blood · doi:10.1182/blood.v99.6.2037 · Cited by 148 · see citing works

Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative Disorder

Hao, S. X., & Ren, R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1149-1161.2000 · Cited by 143 · see citing works

BCR-ABL Induces the Expression of Skp2 through the PI3K Pathway to Promote p27Kip1 Degradation and Proliferation of Chronic Myelogenous Leukemia Cells

Andreu, E. J., Lledó, E., Poch, E., Ivorra, C., Albero, M. P., Martinez-Climent, J. A., Montiel‐Duarte, C., Rifón, J., Pérez‐Calvo, J., Arbona, C., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1357 · Cited by 141 · see citing works

Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML

Yong, A. S. M., Szydlo, R., Goldman, J. M., Apperley, J. F., & Melo, J. V. (2005) · Blood · doi:10.1182/blood-2005-05-2155 · Cited by 139 · see citing works

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G 1

Wu, C., Classon, M., Dyson, N. J., & Harlow, E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3698 · Cited by 139 · see citing works

Bcr/Abl expression stimulates integrin function in hematopoietic cell lines.

Bazzoni, G., Carlesso, N., Griffin, J. D., & Hemler, M. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118820 · Cited by 126 · see citing works

DLC‐1, a Rho GTPase‐activating protein with tumor suppressor function, is essential for embryonic development

Durkin, M. E., Avner, M. R., Huh, C.-G., Yuan, B., Thorgeirsson, S. S., & Popescu, N. C. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.12.090 · Cited by 119 · see citing works

Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis

Zheng, C., Li, L., Haak, M., Brors, B., Frank, O., Giehl, M., Fabarius, A. C., Schatz, M. C., Weisser, A., Lorentz, C., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404227 · Cited by 117 · see citing works

The Activity of Guanine Exchange Factor NET1 Is Essential for Transforming Growth Factor-β-mediated Stress Fiber Formation

Shen, X., Li, J., Hu, P. P.-C., Waddell, D. S., Zhang, J., & Wang, X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009534200 · Cited by 116 · see citing works

Chronic myelogenous leukemia molecular signature

Nowicki, M. O., Pawlowski, P., Fischer, T. H., Heß, G., Pawlowski, T., & Skórski, T. (2003) · Oncogene · doi:10.1038/sj.onc.1206620 · Cited by 114 · see citing works

Activation of RhoA and SAPK/JNK signalling pathways by the RhoA‐specific exchange factor mNET1

Alberts, A. S., & Treisman, R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.4075 · Cited by 114 · see citing works

Identification of genes involved in imatinib resistance in CML: a gene-expression profiling approach

Villuendas, R., Steegmann, J. L., Pollán, M., Tracey, L., Granda, A., Fernández‐Ruiz, E., Casado, L., Martínez‐López, J., Martinez, P. B., Lombardía, L., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404197 · Cited by 110 · see citing works

The Adapter Protein Crkl Links Cbl to C3G after Integrin Ligation and Enhances Cell Migration

Uemura, N., & Griffin, J. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37525 · Cited by 110 · see citing works

Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients

Frank, O., Brors, B., Fabarius, A. C., Li, L., Haak, M., Merk, S., Schwindel, U., Zheng, C., Müller, M. C., Gretz, N., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404270 · Cited by 109 · see citing works

Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathwayPreprint

Dai, Z., Quackenbush, R. C., Courtney, K. D., Grove, M., Cortez, D., Reuther, G. W., & Pendergast, A. M. (1998) · Genes & Development · doi:10.1101/gad.12.10.1415 · Cited by 109 · see citing works

Expression of matrix metalloproteinases (MMP-2 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells

Janowska‐Wieczorek, A., Marquez‐Curtis, L. A., Matsuzaki, A., Hashmi, H., Larratt, L. M., Boshkov, L., Turner, A. R., Zhang, M., Edwards, D. R., & Kossakowska, A. E. (1999) · British Journal of Haematology · doi:10.1111/j.1365-2141.1999.01352.x · Cited by 107 · see citing works

Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2

Burchert, A. (2003) · Blood · doi:10.1182/blood-2003-08-2970 · Cited by 102 · see citing works

Persistent Transactivation by Meis1 Replaces Hox Function in Myeloid Leukemogenesis Models: Evidence for Co-Occupancy of Meis1-Pbx and Hox-Pbx Complexes on Promoters of Leukemia-Associated Genes

Wang, G. G., Pasillas, M. P., & Kamps, M. P. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3902-3916.2006 · Cited by 97 · see citing works

Tissue inhibitor of metalloproteinases-1 signalling pathway leading to erythroid cell survival

Lambert, E., Boudot, C., Kadri, Z., Soula-Rothhut, M., Sowa, M.-L., Mayeux, P., Hornebeck, W., Haye, B., & Petitfrere, E. (2003) · Biochemical Journal · doi:10.1042/bj20030187 · Cited by 94 · see citing works

Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity

Ng, Y. Y., van Kessel, B., Lokhorst, H. M., Baert, M. R. M., van den Burg, C. M. M., Bloem, A. C., & Staal, F. J. T. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603287 · Cited by 90 · see citing works

Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells

Ohmine, K., Ota, J., Ueda, M., Ueno, S., Yoshida, K., Yamashita, Y., Kirito, K., Imagawa, S., Nakamura, Y., Saito, K., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1205029 · Cited by 79 · see citing works

Pharmacogenomic Analysis of Cytogenetic Response in Chronic Myeloid Leukemia Patients Treated with Imatinib

McLean, L. A., Gathmann, I., Capdeville, R., Polymeropoulos, M. H., & Dressman, M. A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0784-3 · Cited by 79 · see citing works

Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities

Konopleva, M. Y., Mikhail, A. A., Estrov, Z. E., et al. (1999) · Blood · doi:10.1182/blood.v93.5.1668.405a15_1668_1676 · Cited by 78 · see citing works

Immature Leukemic CD34 + CXCR4 + Cells from CML Patients Have Lower Integrin‐Dependent Migration and Adhesion in Response to the Chemokine SDF‐1

Peled, A., Hardan, I., Trakhtenbrot, L., Gur, E., Magid, M., Darash‐Yahana, M., Cohen, N., Grabovsky, V., Franitza, S., Kollet, Ó., et al. (2002) · Stem Cells · doi:10.1634/stemcells.20-3-259 · Cited by 77 · see citing works

Abnormalities in the erythroid progenitor compartments in patients with chronic myelogenous leukemia (CML).

Eaves, A., & Eaves, C. (1979) · PubMed · Cited by 65 · see citing works

Interferon consensus sequence binding protein: Not essential for interferon alpha-mediated antiviral response to vesicular-stomatitis virus infection in HL-60 cells

Park, B.-K. (2001) · Immune Network · doi:10.4110/in.2001.1.2.109 · Cited by 60 · see citing works

Chronic myeloid leukaemia: stem cell derived but progenitor cell driven

Marley, S. B., & Gordon, M. Y. (2005) · Clinical Science · doi:10.1042/cs20040336 · Cited by 59 · see citing works

Distinct molecular phenotype of malignant CD34+ hematopoietic stem and progenitor cells in chronic myelogenous leukemia

Kronenwett, R., Butterweck, U., Steidl, U. U., Kliszewski, S., Neumann, F., Bork, S., Blanco, E. D., Roes, N., Graef, T. T., Brors, B., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208596 · Cited by 59 · see citing works

Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML

Salesse, S., & Verfaillie, C. M. (2002) · Oncogene · doi:10.1038/sj.onc.1206088 · Cited by 54 · see citing works

Characterization of the Biochemical and Transforming Properties of the Neuroepithelial Transforming Protein 1

Qin, H., Carr, H. S., Wu, X., Muallem, D. R., Tran, N. H., & Frost, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412141200 · Cited by 53 · see citing works

Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networks

Staal, F. J. T., Cario, G., Cazzaniga, G., Haferlach, T., Heuser, M., Hofmann, W. ‐., Mills, K., Schrappe, M., Stanulla, M., Wingen, L. U., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404274 · Cited by 53 · see citing works

Expression of the leptin receptor in human leukaemic blast cells

Nakao, T., Hino, M., Yamane, T., Nishizawà, Y., Morii, H., & Tatsumi, N. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00843.x · Cited by 52 · see citing works

Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development

Wertheim, J. A., Perera, S. A., Hammer, D. A., Ren, R., Boettiger, D. C., & Pear, W. S. (2003) · Blood · doi:10.1182/blood-2003-01-0062 · Cited by 48 · see citing works

Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cells

Nakata, Y., Tomkowicz, B. E., Gewirtz, A. M., & Ptasznik, A. (2006) · Blood · doi:10.1182/blood-2005-08-3343 · Cited by 47 · see citing works

Characterization of Cell Cycle Status and E2F Complexes in Mobilized CD34+ Cells Before and After Cytokine Stimulation

Williams, C. D., Linch, D. C., Watts, M., & Thomas, N. S. B. (1997) · Blood · doi:10.1182/blood.v90.1.194 · Cited by 47 · see citing works

Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors

Malhotra, K., Malhotra, K., Lubin, B. H., & Kuypers, F. A. (1999) · Biochemical Journal · doi:10.1042/bj3440135 · Cited by 45 · see citing works

A sustained and pancellular reversal of gamma-globin gene silencing in adult human erythroid precursor cells

Bhanu, N. V., Trice, T. A., Lee, Y. T., Gantt, N. M., Oneal, P. A., Schwartz, J. D., Noël, P., & Miller, J. L. (2004) · Blood · doi:10.1182/blood-2004-04-1599 · Cited by 39 · see citing works

Biological effects of stroma-derived factor-1α on normal and CML CD34+ haemopoietic cells

Dürig, J., Rosenthal, C., Elmaagacli, A. H., Heyworth, C. M., Halfmeyer, K., Kasper, C., Novotný, J., & Dührsen, U. (2000) · Leukemia · doi:10.1038/sj.leu.2401875 · Cited by 39 · see citing works

Differences between normal and cml stem cells: Potential targets for clinical exploitation

Eaves, A. C., Barnett, M. J., Ponchio, L., Cashman, J., Petzer, A. L., & Eaves, C. J. (2009) · Stem Cells · doi:10.1002/stem.5530160809 · Cited by 36 · see citing works

GCKR Links the Bcr-Abl Oncogene and Ras to the Stress-Activated Protein Kinase Pathway

Shi, C.-S., Tuscano, J. M., Witte, O. N., & Kehrl, J. H. (1999) · Blood · doi:10.1182/blood.v93.4.1338 · Cited by 34 · see citing works

Differential effects of TGF-beta 1 on normal and leukemic human hematopoietic cell proliferation.

MUROHASHI, I., Endho, K., Nishida, S., Yoshida, S., Jinnai, I., Bessho, M., & HIRASHIMA, K. (1995) · PubMed · Cited by 32 · see citing works

Selectively increased growth of fetal hemoglobin-expressing adult erythroid progenitors after brief treatment of early progenitors with transforming growth factor beta

Böhmer, R. M., Campbell, T. A., & Bianchi, D. W. (2000) · Blood · doi:10.1182/blood.v95.9.2967.009k21_2967_2974 · Cited by 31 · see citing works

Leptin: A Promising Therapeutic Target with Pleiotropic Action Besides Body Weight Regulation

Paraskevas, K. I., Liapis, C. D., & Mikhailidis, D. P. (2006) · Current Drug Targets · doi:10.2174/138945006777435371 · Cited by 27 · see citing works

Impact of BCR/ABL gene expression on the proliferative rate of different subpopulations of haematopoietic cells in chronic myeloid leukaemia

Primo, D., Flores-Montero, J. A., Quijano, S., Sánchez, M. L., Sarasquete, M. E., del Pino‐Montes, J., Gaarder, P. I., González, M., & Órfão, A. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06265.x · Cited by 27 · see citing works

Inhibition of angiogenesis in vitro by αv integrin–directed antisense oligonucleotides

Kronenwett, R., Graef, T. T., Nedbal, W., Weber, M., Steidl, U. U., Rohr, U., Möhler, T., & Haas, R. R. (2002) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700474 · Cited by 22 · see citing works

Gene expression profiling of Philadelphia chromosome (Ph)-negative CD34+ hematopoietic stem and progenitor cells of patients with Ph-positive CML in major molecular remission during therapy with imatinib

Neumann, F., Teutsch, N., Kliszewski, S., Bork, S., Steidl, U. U., Brors, B., Schimkus, N., Roes, N., Germing, U., Hildebrandt, B., et al. (2004) · Leukemia · doi:10.1038/sj.leu.2403615 · Cited by 20 · see citing works

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

Baccarani, M., Cortes, J. E., Pane, F., Niederwieser, D. W., Saglio, G. N., Apperley, J. F., Cervantes, F., Deininger, M. W., Gratwohl, A. A., Guilhot, F., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.0779 · Cited by 1,276 · see citing works

The IRF Family Transcription Factors in Immunity and Oncogenesis

Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259 · see citing works

Regulation of immunity and oncogenesis by the IRF transcription factor family

Savitsky, D., Tamura, T., Yanai, H., & Taniguchi, T. (2010) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-009-0804-6 · Cited by 298 · see citing works

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow

Lee, J., Breton, G., Oliveira, T. Y., Zhou, Y. J., Aljoufi, A., Puhr, S., Cameron, M. J., Sékaly, R., Nussenzweig, M. C., & Liu, K. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141442 · Cited by 258 · see citing works

Myc Roles in Hematopoiesis and Leukemia

Delgado, M. D., & León, J. (2010) · Genes & Cancer · doi:10.1177/1947601910377495 · Cited by 248 · see citing works

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

Abraham, S. A., Hopcroft, L. E. M., Carrick, E., Drotar, M. E., Dunn, K., Williamson, A. J. K., Korfi, K., Baquero, P., Park, L. E., Scott, M. T., et al. (2016) · Nature · doi:10.1038/nature18288 · Cited by 225 · see citing works

Subtype-specific 3D genome alteration in acute myeloid leukaemia

Xu, J., Song, F., Lyu, H., Kobayashi, M., Zhang, B., Zhao, Z., Hou, Y., Wang, X., Luan, Y., Jia, B., et al. (2022) · Nature · doi:10.1038/s41586-022-05365-x · Cited by 208 · see citing works

Mechanisms of leukemogenesis by MLL fusion proteins

Marschalek, R. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08459.x · Cited by 185 · see citing works

Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein

Järås, M., Johnels, P., Hansen, N., Ågerstam, H., Tsapogas, P., Rissler, M., Lassen, C., Olofsson, T., Bjerrum, O. W., Richter, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004408107 · Cited by 185 · see citing works

The Multiple Roles of Interferon Regulatory Factor family in Health and Disease

Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01980-4 · Cited by 178 · see citing works

Chronic myeloid leukemia stem cells

Houshmand, M., Simonetti, G., Circosta, P., Gaidano, V., Cignetti, A., Martinelli, G., Saglio, G. N., & Gale, R. P. (2019) · Leukemia · doi:10.1038/s41375-019-0490-0 · Cited by 177 · see citing works

MicroRNA-126 Regulates HOXA9 by Binding to the Homeobox

Shen, W.-F., Hu, Y., Uttarwar, L., Passegue, E. A., & Largman, C. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01652-07 · Cited by 150 · see citing works

Role of Distinct Natural Killer Cell Subsets in Anticancer Response

Stabile, H., Fionda, C., Gismondi, A., & Santoni, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00293 · Cited by 149 · see citing works

Insights into the stem cells of chronic myeloid leukemia

Sloma, I., Jiang, X.-Y., Eaves, A., & Eaves, C. (2010) · Leukemia · doi:10.1038/leu.2010.159 · Cited by 130 · see citing works

Transcriptional Analysis of Quiescent and Proliferating CD34+ Human Hemopoietic Cells from Normal and Chronic Myeloid Leukemia Sources

Graham, S. M., Vass, J. K., Holyoake, T. L., & Graham, G. J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0250 · Cited by 96 · see citing works

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

Schemionek, M., Elling, C., Steidl, U. G., Bäumer, N., Hamilton, A., Spieker, T., Göthert, J. R., Stehling, M., Wagers, A. J., Huettner, C. S., et al. (2010) · Blood · doi:10.1182/blood-2009-04-215376 · Cited by 95 · see citing works

The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence

Bruns, I., Czibere, A. G., Fischer, J., Roels, F., Cadeddu, R.-P., Buest, S., Brünnert, D., Huenerlituerkoglu, A.-N., Stoecklein, N., Singh, R., et al. (2009) · Leukemia · doi:10.1038/leu.2008.392 · Cited by 81 · see citing works

The EBV Latent Antigen 3C Inhibits Apoptosis through Targeted Regulation of Interferon Regulatory Factors 4 and 8

Banerjee, S., Lu, J. L., Cai, Q., Saha, A., Jha, H. C., Dzeng, R. K., & Robertson, E. S. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003314 · Cited by 81 · see citing works

A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes

Careccia, S., Mainardi, S., Pelosi, A., Gurtner, A., Diverio, D., Riccioni, R., Testa, U., Pelosi, E., Piaggio, G., Sacchi, A., et al. (2009) · Oncogene · doi:10.1038/onc.2009.255 · Cited by 81 · see citing works

Yin Yang 1 expression in human tumors

Zaravinos, A., & Spandidos, D. A. (2010) · Cell Cycle · doi:10.4161/cc.9.3.10588 · Cited by 79 · see citing works

Monocyte derived dendritic cells generated by IFN-α acquire mature dendritic and natural killer cell properties as shown by gene expression analysis

Korthals, M., Safaian, N., Kronenwett, R., Maihöfer, D., Schott, M., Papewalis, C., Blanco, E. D., Winter, M., Czibere, A. G., Haas, R. R., et al. (2007) · Journal of Translational Medicine · doi:10.1186/1479-5876-5-46 · Cited by 78 · see citing works

Co-clustering phenome–genome for phenotype classification and disease gene discovery

Hwang, T., Atluri, G., Xie, M., Dey, S., Hong, C., Kumar, V., & Kuang, R. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks615 · Cited by 75 · see citing works

Aurora-A kinase: a novel target of cellular immunotherapy for leukemia

Ochi, T., Fujiwara, H., Suemori, K., Azuma, T., Yakushijin, Y., Hato, T., Kuzushima, K., & Yasukawa, M. (2008) · Blood · doi:10.1182/blood-2008-06-164889 · Cited by 75 · see citing works

IRF8 Regulates Acid Ceramidase Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia

Hu, X., Yang, D., Zimmerman, M. A., Liu, F., Yang, J., Kannan, S., Burchert, A., Szulc, Z. M., Bielawska, A. E., Ozato, K., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2493 · Cited by 72 · see citing works

CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting

Landberg, N., von Palffy, S., Askmyr, M., Lilljebjörn, H., Sandén, C., Rissler, M., Mustjoki, S. M., Hjorth‐Hansen, H., Richter, J., Ågerstam, H., et al. (2017) · Haematologica · doi:10.3324/haematol.2017.169946 · Cited by 70 · see citing works

Chronic Myeloid Leukemia Stem Cells

Jamieson, C. H. M. (2008) · Hematology · doi:10.1182/asheducation-2008.1.436 · Cited by 68 · see citing works

Molecular and functional analysis of the stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34− cell population with intrinsic resistance to imatinib

Lemoli, R. M., Salvestrini, V., Bianchi, E., Bertolini, F., Fogli, M., Amabile, M., Tafuri, A., Salati, S., Zini, R., Testoni, N., et al. (2009) · Blood · doi:10.1182/blood-2008-08-176016 · Cited by 67 · see citing works

Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy

Humbert, M., Seiler, K., Mosimann, S., Rentsch, V., Sharma, K., Pandey, A. V., McKenna, S. L., & Tschan, M. P. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00768-1 · Cited by 64 · see citing works

MYC oncogene in myeloid neoplasias

Delgado, M. D., Albajar, M., Gómez‐Casares, M. T., Batlle, A., & León, J. (2012) · Clinical & Translational Oncology · doi:10.1007/s12094-012-0926-8 · Cited by 63 · see citing works

Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis

Thomas, E. K., Cancelas, J. A., Zheng, Y., & Williams, D. A. (2008) · Leukemia · doi:10.1038/leu.2008.71 · Cited by 62 · see citing works

MYC in chronic myeloid leukemia: induction of aberrant DNA synthesis and association with poor response to imatinib

Albajar, M., Gómez-Casares, M. T., Llorca, J., Mauleon, I., Vaqué, J. P., Acosta, J. C., Bermúdez, A., Donato, N., Delgado, M. D., & León, J. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0356 · Cited by 62 · see citing works

Emerging stem cell concepts for imatinib‐resistant chronic myeloid leukaemia: implications for the biology, management, and therapy of the disease

Valent, P. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07197.x · Cited by 61 · see citing works

A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis

Shen, N., Yan, F., Pang, J., Wu, L., Al‐Kali, A., Litzow, M. R., & Liu, S. (2014) · Oncotarget · doi:10.18632/oncotarget.2131 · Cited by 55 · see citing works

Efficacious Immune Therapy in Chronic Myelogenous Leukemia (CML) Recognizes Antigens That Are Expressed on CML Progenitor Cells

Biernacki, M. A., Marina, O., Zhang, W., Liu, F., Bruns, I., Cai, A., Neuberg, D. S., Canning, C. M., Alyea, E. P., Soiffer, R. J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2303 · Cited by 52 · see citing works

Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance

Scheller, M., Schönheit, J., Zimmermann, K., Leser, U., Rosenbauer, F., & Leutz, A. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130706 · Cited by 48 · see citing works

Growth Arrest Specific 2 Is Up-Regulated in Chronic Myeloid Leukemia Cells and Required for Their Growth

Zhou, H., Ge, Y., Sun, L., Ma, W., Wu, J., Zhang, X., Hu, X., Eaves, C. J., Wu, D., & Zhao, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086195 · Cited by 45 · see citing works

Sorcin silencing inhibits epithelial-to-mesenchymal transition and suppresses breast cancer metastasis in vivo

Hu, Y., Li, S., Yang, M., Yan, C., Fan, D., Zhou, Y., Zhang, Y., Yagüe, E., & Xiong, D. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2809-2 · Cited by 41 · see citing works

Gene Expression Differences between Enriched Normal and Chronic Myelogenous Leukemia Quiescent Stem/Progenitor Cells and Correlations with Biological Abnormalities

Affer, M., Dao, S., Liu, C., Olshen, A. B., Mo, Q., Viale, A. J., Lambek, C. L., Marr, T. G., & Clarkson, B. (2011) · Journal of Oncology · doi:10.1155/2011/798592 · Cited by 40 · see citing works

Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia

Yu, C., Gorantla, S. P., Rudorf, A., Müller, T. A., Kreutmair, S., Albers, C., Jakob, L., Lippert, L. J., Yue, Z., Engelhardt, M. M., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.212027 · Cited by 39 · see citing works

Inhibition of sorcin reverses multidrug resistance of K562/A02 cells and MCF-7/A02 cells via regulating apoptosis-related proteins

Hu, Y., Cheng, X., Li, S., Zhou, Y., Wang, J., Cheng, T., Yang, M., & Xiong, D. (2013) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-013-2254-2 · Cited by 37 · see citing works

MEIS1, PREP1, and PBX4 Are Differentially Expressed in Acute Lymphoblastic Leukemia: Association of MEIS1 Expression with Higher Proliferation and Chemotherapy Resistance

Rosales-Aviña, J. A., Torres-Flores, J., Aguilar‐Lemarroy, A., Gurrola‐Díaz, C. M., Hernández‐Flores, G., Ortiz‐Lazareno, P. C., Lerma-Díaz, J. M., Célis, R. D., Gonzalez-Ramella, O. R., Barrera‐Chairez, E., et al. (2011) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-30-112 · Cited by 37 · see citing works

Imatinib-resistant chronic myeloid leukemia (CML): Current concepts on pathogenesis and new emerging pharmacologic approaches.

Valent, P. (2007) · PubMed Central · Cited by 35 · see citing works

G0S2 inhibits the proliferation of K562 cells by interacting with nucleolin in the cytosol

Yamada, T., Park, C. S., Shen, Y., Rabin, K. R., & Lacorazza, H. D. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.10.006 · Cited by 34 · see citing works

Potential Role of Notch Signalling in CD34+ Chronic Myeloid Leukaemia Cells: Cross-Talk between Notch and BCR-ABL

Aljedai, A., Buckle, A., Hiwarkar, P., & Syed, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123016 · Cited by 32 · see citing works

NF-κB suppresses ROS levels in BCR–ABL+ cells to prevent activation of JNK and cell death

Stein, S. J., & Baldwin, A. S. (2011) · Oncogene · doi:10.1038/onc.2011.156 · Cited by 32 · see citing works

Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells

Suknuntha, K., Ishii, Y., Tao, L., Hu, K., McIntosh, B. E., Yang, D. T., Swanson, S. A., Stewart, R. M., Wang, J. Y. J., Thomson, J. L., et al. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.10.015 · Cited by 31 · see citing works

Role of bone marrow adipocytes in leukemia and chemotherapy challenges

Samimi, A., Ghanavat, M., Shahrabi, S., Azizidoost, S., & Saki, N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03031-6 · Cited by 32 · see citing works

CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia

Korthuis, P. M., Berger, G., Bakker, B., Geugien, M., Jaques, J., de Haan, G., Schuringa, J. J., Vellenga, E., & Schepers, H. (2014) · Leukemia · doi:10.1038/leu.2014.259 · Cited by 29 · see citing works

Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy

Abe, A., Minami, Y., Hayakawa, F., Kitamura, K., Nomura, Y., Murata, M., Katsumi, A., Kiyoi, H., Jamieson, C. H. M., Wang, J. Y. J., et al. (2008) · International Journal of Hematology · doi:10.1007/s12185-008-0221-1 · Cited by 29 · see citing works

Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha

Schubert, C., Allhoff, M., Tillmann, S., Maié, T., Costa, I. G., Lipka, D. B., Schemionek, M., Feldberg, K., Baumeister, J., Brümmendorf, T. H., et al. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0722-9 · Cited by 29 · see citing works

The Head-to-Toe Hormone: Leptin as an Extensive Modulator of Physiologic Systems

Misch, M., & Puthanveetil, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105439 · Cited by 30 · see citing works

Defective homing and impaired induction of cytotoxic T cells by BCR/ABL-expressing dendritic cells

Mumprecht, S., Claus, C., Schürch, C. M., Pavelic, V., Matter, M. S., & Ochsenbein, A. F. (2009) · Blood · doi:10.1182/blood-2008-05-156471 · Cited by 28 · see citing works

Crosstalk Between MYC and lncRNAs in Hematological Malignancies

Arman, K., & Möröy, T. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.579940 · Cited by 27 · see citing works

C/EBPβ promotes BCR–ABL-mediated myeloid expansion and leukemic stem cell exhaustion

Hayashi, Y., Hirai, H., Kamio, N., Yao, H., Yoshioka, S., Miura, Y., Ashihara, E., Fujiyama, Y., Tenen, D. G., & Maekawa, T. (2012) · Leukemia · doi:10.1038/leu.2012.258 · Cited by 27 · see citing works

The impact of gene profiling in chronic myeloid leukaemia

Yong, A. S. M., & Melo, J. V. (2009) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2009.04.002 · Cited by 27 · see citing works

Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells

Stirewalt, D. L., Choi, Y. E., Sharpless, N. E., Pogosova‐Agadjanyan, E. L., Cronk, M. R., Yukawa, M., Larson, E. B., Wood, B. L., Appelbaum, F. R., Radich, J. P., et al. (2008) · Leukemia · doi:10.1038/leu.2008.176 · Cited by 28 · see citing works

Delayed cytogenetic and major molecular responses associated to increased BMI at baseline in chronic myeloid leukemia patients treated with imatinib

Breccia, M., Loglisci, G., Salaroli, A., Serrao, A., Mancini, M., Diverio, D., Latagliata, R., & Alimena, G. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.12.018 · Cited by 25 · see citing works

Leptin and its receptor in hematologic malignancies.

Han, T., & Wang, X. (2015) · PubMed Central · Cited by 25 · see citing works

Novel Combination Treatments Targeting Chronic Myeloid Leukemia Stem Cells

Baghdadi, T. A., Abonour, R., & Boswell, H. S. (2011) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2011.10.003 · Cited by 24 · see citing works

Comparison of the Transcriptomic Signatures in Pediatric and Adult CML

Youn, M., Smith, S. M., Lee, A. G., Chae, H.-D., Spiteri, E., Erdmann, J., Galperin, I. B., Jones, L. M., Donato, M., Abidi, P., et al. (2021) · Cancers · doi:10.3390/cancers13246263 · Cited by 23 · see citing works

Antigens in chronic myeloid leukemia: implications for vaccine development

Šmahel, M. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1126-z · Cited by 23 · see citing works

Early in vivo changes of the transcriptome in Philadelphia chromosome-positive CD34+ cells from patients with chronic myelogenous leukaemia following imatinib therapy

Brünnert, D., Czibere, A. G., Bruns, I., Kronenwett, R., Gattermann, N., Haas, R. R., & Neumann, F. (2008) · Leukemia · doi:10.1038/leu.2008.337 · Cited by 22 · see citing works

Leptin Reverts Pro-Apoptotic and Antiproliferative Effects of α-Linolenic Acids in BCR-ABL Positive Leukemic Cells: Involvement of PI3K Pathway

Beaulieu, A., Poncin, G., Belaid, Z., Humblet, C., Bogdanovic, G. M., Lognay, G. C., Boniver, J., & Defresne, M.-P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025651 · Cited by 22 · see citing works

Pharmacogenetics and Pharmacogenomics of Targeted Therapeutics in Chronic Myeloid Leukemia

Nath, A., Wang, J., & Huang, R. S. (2017) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-017-0292-x · Cited by 22 · see citing works

Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia

Inselmann, S., Wang, Y., Saußele, S., Fritz, L. V., Schütz, C., Huber, M., Liebler, S., Ernst, T., Cai, D., Botschek, S., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1477 · Cited by 21 · see citing works

Transcriptomic and phospho‐proteomic analyzes of erythroblasts expanded in vitro from normal donors and from patients with polycythemia vera

Hricik, T., Federici, G., Zeuner, A., Alimena, G., Tafuri, A., Tirelli, V., Varricchio, L., Masiello, F., Ciaffoni, F., Vaglio, S., et al. (2013) · American Journal of Hematology · doi:10.1002/ajh.23487 · Cited by 20 · see citing works

Aurora-A kinase: a novel target both for cellular immunotherapy and molecular target therapy against human leukemia

Ochi, T., Fujiwara, H., & Yasukawa, M. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903307483 · Cited by 20 · see citing works

Pleiotropic p27Kip1, BCR-ABL and leukemic stem cell: the trio in concert

Sengupta, A., & Banerjee, S. (2007) · Leukemia · doi:10.1038/sj.leu.2404842 · Cited by 20 · see citing works

Characterization of K562 cells: uncovering novel chromosomes, assessing transferrin receptor expression, and probing pharmacological therapies

Karagiannis, T. C., Wall, M., Ververis, K., Pitsillou, E., Tortorella, S. M., Wood, P. A., Rafehi, H., Khurana, I., Maxwell, S., Hung, A., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04905-6 · Cited by 19 · see citing works

Expression differences of genes in the PI3K/AKT, WNT/b-catenin, SHH, NOTCH and MAPK signaling pathways in CD34+ hematopoietic cells obtained from chronic phase patients with chronic myeloid leukemia and from healthy controls

Carrara, R. C. V., Fontes, A. M., Abraham, K., Orellana, M. D., Kashima, S. H., Palma, P. V. B., Panepucci, R. A., Zago, M. A., & Covas, D. T. (2017) · Clinical & Translational Oncology · doi:10.1007/s12094-017-1751-x · Cited by 19 · see citing works

Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML

Toda, J., Ichii, M., Oritani, K., Shibayama, H., Tanimura, A., Saito, H., Yokota, T., Motooka, D., Okuzaki, D., Kitai, Y., et al. (2020) · Oncogene · doi:10.1038/s41388-020-01387-9 · Cited by 20 · see citing works

The Prognostic Significance of IRF8 Transcripts in Adult Patients with Acute Myeloid Leukemia

Pogosova‐Agadjanyan, E. L., Kopecky, K. J., Ostronoff, F., Appelbaum, F. R., Godwin, J. E., Lee, H., List, A. F., May, J. J., Oehler, V. G., Petersdorf, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070812 · Cited by 20 · see citing works

Expression profiling of circulating non-red blood cells in embryonic blood

McIntyre, B. A. S., Alev, C., Tarui, H., Jakt, L. M., & Sheng, G. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-21 · Cited by 19 · see citing works

Gene expression analysis of BCR/ABL1‐dependent transcriptional response reveals enrichment for genes involved in negative feedback regulation

Håkansson, P., Nilsson, B., Andersson, A., Lassen, C., Gullberg, U., & Fioretos, T. (2008) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20528 · Cited by 18 · see citing works

Proteomics analysis of MPP+-induced apoptosis in SH-SY5Y cells

Xie, H., Chang, M., Hu, X., Wang, D., Tian, M., Li, G., Jiang, H., Wang, Y., Dong, Z., Zhang, Y., et al. (2010) · Neurological Sciences · doi:10.1007/s10072-010-0340-3 · Cited by 18 · see citing works

Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism

Gonzalez, M. A., Olivas, I. M., Bencomo-Alvarez, A. E., Rubio, A. J., Barreto‐Vargas, C., López, J. L. G., Dang, S. K., Solecki, J. P., McCall, E. B., Astudillo, G. E., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1146 · Cited by 17 · see citing works

Grb10 is involved in BCR-ABL-positive leukemia in mice

Illert, A. L., Albers, C., Kreutmair, S., Leischner, H., Peschel, C., Miething, C., & Duyster, J. (2014) · Leukemia · doi:10.1038/leu.2014.283 · Cited by 17 · see citing works

Single cell sequencing reveals cell populations that predict primary resistance to imatinib in chronic myeloid leukemia

Zhang, W., Yang, B., Weng, L., Li, J., Bai, J., Wang, T., Wang, J., Ye, J., Jing, H., Jiao, Y., et al. (2020) · Aging · doi:10.18632/aging.104136 · Cited by 15 · see citing works

Uncovering two neutrophil-committed progenitors that immediately precede promyelocytes during human neutropoiesis

Signoretto, I., Calzetti, F., Finotti, G., Lonardi, S., Balanzin, C., Bianchetto-Aguilera, F. M., Gasperini, S., Gardiman, E., Castellucci, M., Russignan, A., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01259-w · Cited by 14 · see citing works

Statins Enhance the Molecular Response in Chronic Myeloid Leukemia when Combined with Tyrosine Kinase Inhibitors

Jang, H.-J., Woo, Y.-M., Naka, K., Park, J.-H., Han, H. J., Kim, H., Kim, S., Ahn, J., Kim, T. P., Kimura, S. H., et al. (2021) · Cancers · doi:10.3390/cancers13215543 · Cited by 14 · see citing works

Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia

Chan, L., Lin, X., Yung, G., Lui, T. K.-L., Chiu, Y. M., Wang, F., Tsui, N. B. Y., Cho, W. C. S., Yip, S. P., Siu, P. M., et al. (2015) · Scientific Reports · doi:10.1038/srep10973 · Cited by 14 · see citing works

Gene expression profile of circulating CD34+ cells and granulocytes in chronic myeloid leukemia

Čokić, V. P., Mojsilović, S. B., Jauković, A., Kraguljac‐Kurtović, N., Mojsilović, S. S., Šefer, D., Ajtić, O. M., Milošević, V., Bogdanovic, A. D., Đikić, D., et al. (2015) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2015.08.002 · Cited by 14 · see citing works

Profiling conserved biological pathways in Autosomal Dominant Polycystic Kidney Disorder (ADPKD) to elucidate key transcriptomic alterations regulating cystogenesis: A cross-species meta-analysis approach

Chatterjee, S., Verma, S. P., & Pandey, P. (2017) · Gene · doi:10.1016/j.gene.2017.06.059 · Cited by 14 · see citing works

Knockout of LASP1 in CXCR4 expressing CML cells promotes cell persistence, proliferation and TKI resistance

Herrmann, A. B., Müller, M., Orth, M. F., Müller, J. P., Zernecke, A., Hochhaus, A., Ernst, T., Butt, E., & Frietsch, J. J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14910 · Cited by 14 · see citing works

Stem Cell Biomarkers in Chronic Myeloid Leukemia

Jiang, X., Zhao, Y. S., Forrest, D. L., Smith, C. A., Eaves, A. C., & Eaves, C. J. (2008) · Disease Markers · doi:10.1155/2008/146871 · Cited by 14 · see citing works

Imatinib Mesylate Therapy Induces Reduction in Neutrophil Gelatinase-Associated Lipocalin Serum Levels and Increase in Leptin Concentrations in Chronic Myeloid Leukemia Patients in Molecular Remission

Alonci, A., Allegra, A., Russo, S., Penna, G., Bellomo, G., D’Angelo, A., Campo, S., Cannavò, A., Centorrino, R., & Musolino, C. (2011) · Acta Haematologica · doi:10.1159/000330948 · Cited by 13 · see citing works

Aberrant Chloride Intracellular Channel 4 Expression Is Associated With Adverse Outcome in Cytogenetically Normal Acute Myeloid Leukemia

Huang, S., Huang, Z., Chen, P., & Feng, C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01648 · Cited by 12 · see citing works

Leptin Receptor in Childhood Acute Leukemias

Górska, E., Popko, K., & Wasik, M. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-4549-0_20 · Cited by 12 · see citing works

Potential functions of hsa-miR-155-5p and core genes in chronic myeloid leukemia and emerging role in human cancer: A joint bioinformatics analysis

Soltani, I., Bahia, W., Farrah, A., Mahdhi, A., Ferchichi, S., & Almawi, W. Y. (2021) · Genomics · doi:10.1016/j.ygeno.2021.04.014 · Cited by 11 · see citing works

Phenotypic and gene expression diversity of malignant cells in human blast crisis chronic myeloid leukemia

Simanovsky, M., Berlinsky, S., Sinai, P., Leiba, M., Nagler, A., & Galski, H. (2008) · Differentiation · doi:10.1111/j.1432-0436.2008.00270.x · Cited by 11 · see citing works

Expression of P190 and P210 BCR/ABL1 in normal human CD34+ cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage

Järås, M., Johnels, P., Ågerstam, H., Lassen, C., Rissler, M., Edén, P., Cammenga, J., Olofsson, T., Bjerrum, O. W., Richter, J., et al. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2008.11.003 · Cited by 11 · see citing works

MYC as therapeutic target in leukemia and lymphoma

León, J., Cortiguera, M. G., Batlle‐López, A., Albajar, M., & Delgado, M. D. (2015) · Blood and Lymphatic Cancer Targets and Therapy · doi:10.2147/blctt.s60495 · Cited by 10 · see citing works

Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells

Hara, T., Schwieger, M., Kazama, R., Okamoto, S., Minehata, K., Ziegler, M., Löhler, J., & Stocking, C. (2008) · Oncogene · doi:10.1038/sj.onc.1211043 · Cited by 10 · see citing works

Antileukemic potential of methylated indolequinone MAC681 through immunogenic necroptosis and PARP1 degradation

Orlikova-Boyer, B., Lorant, A., Gajulapalli, S. R., Cerella, C., Schnekenburger, M., Lee, J.-Y., Paik, J. Y., Lee, Y., Siegel, D. M., Ross, D., et al. (2024) · Biomarker Research · doi:10.1186/s40364-024-00594-w · Cited by 9 · see citing works

Compromised anti-tumor–immune features of myeloid cell components in chronic myeloid leukemia patients

Harada, I., Sasaki, H., Murakami, K., Nishiyama, A., Nakabayashi, J., Ichino, M., Miyazaki, T., Kumagai, K., Matsumoto, K., Hagihara, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-97371-8 · Cited by 9 · see citing works

Gene Network Exploration of Crosstalk between Apoptosis and Autophagy in Chronic Myelogenous Leukemia

Wang, F., Cho, W. C. S., Chan, L., Wong, S. C. C., Tsui, N. B. Y., Siu, P. M., Yip, S. P., & Yung, B. Y. (2015) · BioMed Research International · doi:10.1155/2015/459840 · Cited by 8 · see citing works

Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

Rodriguez, J., Iniguez, A., Jena, N., Tata, P. V., Liu, Z., Lander, A. D., Lowengrub, J. S., & Etten, R. A. V. (2023) · eLife · doi:10.7554/elife.84149 · Cited by 9 · see citing works

Microarray Analysis Using a Limited Amount of Cells

Peterková, M., Koutná, I., Tesařová, L., Potěšilová, M., Kozubek, M., Hrabčáková, V., Klabusay, M., Doubek, M., & Mayer, J. (2009) · Folia Biologica · doi:10.14712/fb2009055020053 · Cited by 8 · see citing works

Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases

Ichii, M., Oritani, K., Toda, J., Hosen, N., Matsuda, T., & Kanakura, Y. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.11.002 · Cited by 7 · see citing works

BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

Brumatti, G., Kaloni, D., de Castro, F. A., & Amarante-Mendes, G. P. (2023) · Biochemical Journal · doi:10.1042/bcj20210608 · Cited by 7 · see citing works

Molecular Signature of Distinct CD34+ Hematopoietic Stem and Progenitor Cell Subsets of Patients with CML in Chronic Phase.

Bruns, I., Czibere, A. G., Fischer, J., Steidl, U. G., Pechtel, S., Koch, A., Brünnert, D., Büst, S., Cadeddu, R., Kronenwett, R., et al. (2007) · Blood · doi:10.1182/blood.v110.11.3170.3170

Molecular Phenotype of Malignant CD34+ Hematopoietic Stem and Progenitor Cells in Chronic Myelogenous Leukemia.

Kronenwett, R., Blanco, E. D., Graef, T. T., Steidl, U. U., Kliszewski, S., Bruns, I., Neumann, F., Bork, S., Butterweck, U., Roes, N., et al. (2005) · Blood · doi:10.1182/blood.v106.11.2863.2863

Molecular signature and functional analysis of leukemic and normal CD34+ hematopoietic stem and progenitor cells

Blanco, E. D. (2008) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver

Distinct molecular phenotype of malignant CD34+ hematopoietic stem and progenitor cells in chronic myelogenous leukemia

Kronenwett, R., Butterweck, U., Steidl, U. U., Kliszewski, S., Neumann, F., Bork, S., Blanco, E. D., Roes, N., Graef, T. T., Brors, B., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208596 · Cited by 59 · see citing works

Expression differences of genes in the PI3K/AKT, WNT/b-catenin, SHH, NOTCH and MAPK signaling pathways in CD34+ hematopoietic cells obtained from chronic phase patients with chronic myeloid leukemia and from healthy controls

Carrara, R. C. V., Fontes, A. M., Abraham, K., Orellana, M. D., Kashima, S. H., Palma, P. V. B., Panepucci, R. A., Zago, M. A., & Covas, D. T. (2017) · Clinical & Translational Oncology · doi:10.1007/s12094-017-1751-x · Cited by 19 · see citing works