The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Alterations in Brain Activation During Working Memory Processing Associated With Breast Cancer and Treatment: A Prospective Functional Magnetic Resonance Imaging Study
Open accessAbstract
Purpose: To prospectively examine alterations in working memory (WM) –associated brain activation related to breast cancer and treatment by using functional magnetic resonance imaging. Patients and Methods: Patients treated with chemotherapy (CTx+; n = 16) or without chemotherapy (CTx−; n = 12) and healthy controls (n = 15) were scanned during an n-back task at baseline (after surgery but before radiation, chemotherapy, and/or antiestrogen treatment), 1 month after completion of chemotherapy (M1), and 1 year later (Y1), or at yoked intervals for CTx− and controls. SPM5 was used for all image analyses, which included cross-sectional between-group and group-by-time interaction and longitudinal within-group analyses, all using a statistical threshold of 0.001. Results: At baseline, patients with cancer showed increased bifrontal and decreased left parietal activation compared with controls. At M1, both cancer groups showed decreased frontal hyperactivation compared with controls, with increased hyperactivation at Y1. These cross-sectional findings were confirmed by group-by-time interaction analyses, which showed frontal activation decreases from baseline to M1 in patients compared with controls. Within-group analyses showed different patterns of longitudinal activation change by treatment group (CTx+ or CTx−), with prominent alterations in the frontal lobes bilaterally. Conclusion: Significant frontal lobe hyperactivation to support WM was found in patients with breast cancer. Superimposed on this background, patients showed decreased frontal activation at M1, with partial return to the previously abnormal baseline at Y1. These functional changes correspond to frontal lobe regions where we previously reported structural changes in this cohort and provide prospective, longitudinal data that further elucidate mechanisms underlying cognitive effects related to breast cancer and its treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Spielberger, C. D. (2010) · The Corsini Encyclopedia of Psychology · doi:10.1002/9780470479216.corpsy0943 · Cited by 2,535
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
Dickerson, B. C., Salat, D. H., Greve, D. N., Chua, E. F., Rand-Giovannetti, E., Rentz, D. M., Bertram, L., Mullin, K., Tanzi, R. E., Blacker, D., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000171450.97464.49 · Cited by 910
Hann (1998) · Quality of Life Research · doi:10.1023/a:1008842517972 · Cited by 500
Berman, K. F., Schmidt, P. J., Rubinow, D. R., Danaceau, M. A., Van Horn, J. D., Esposito, G., Ostrem, J. L., & Weinberger, D. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8836 · Cited by 318
Identifying clinically meaningful fatigue with the fatigue symptom inventory
Donovan, K. A., Jacobsen, P. B., Small, B. J., Munster, P. N., & Andrykowski, M. A. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2007.11.013 · Cited by 144
Cited by
Lange, M., Joly, F., Vardy, J., Ahles, T., Dubois, M., Tron, L., Winocur, G., De Ruiter, M. B., & Castel, H. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz410 · Cited by 667
Self-citationCognitive Effects of Cancer and Cancer Treatments
Ahles, T. A., & Root, J. C. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050817-084903 · Cited by 367
Self-citationRecovery from chemotherapy-induced white matter changes in young breast cancer survivors?
Billiet, T., Emsell, L., Vandenbulcke, M., Peeters, R., Christiaens, D., Leemans, A., Van Hecke, W., Smeets, A., Amant, F., Sunaert, S., et al. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9665-8 · Cited by 81
Kesler, S. R., Adams, M., Packer, M., Rao, V., Henneghan, A. M., Blayney, D. W., & Palesh, O. (2017) · Brain and Behavior · doi:10.1002/brb3.643 · Cited by 77
The Effect of Systemic Chemotherapy on Neurogenesis, Plasticity and Memory
Wigmore, P. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_235 · Cited by 66
Metadata
- Authors
- McDonald, B. C., Conroy, S. K., Ahles, T. A., West, J. D., & Saykin, A. J.
- Venue
- Journal of Clinical Oncology
- Published
- 2012-07-10
- Volume
- 30
- Issue
- 20
- Pages
- 2500-2508
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2153599751
- Cited by
- 282
- References
- 5
- FWCI
- 17.31
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Alterations in Brain Activation During Working Memory Processing Associated With Breast Cancer and Treatment: A Prospective Functional Magnetic Resonance Imaging Study. https://app.cochat.ai/papers/10.1200/jco.2011.38.5674
- The paper
- McDonald, B. C., Conroy, S. K., Ahles, T. A., West, J. D., & Saykin, A. J. (2012). Alterations in Brain Activation During Working Memory Processing Associated With Breast Cancer and Treatment: A Prospective Functional Magnetic Resonance Imaging Study. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2011.38.5674
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
