Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer
Lehmann, Sören, Bykov, Vladimir J.N., Ali, Dina, Andrén, Ove, Cherif, Honar, Tidefelt, Ulf, Uggla, Bertil, Yachnin, Jeffrey, Juliusson, Gunnar, Moshfegh, Ali, Paul, Christer, Wiman, Klas G., Andersson, Per-Ola·2012·Journal of Clinical Oncology
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- Sensitivity of pancreatic cancer cells to chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals can be regulated by WT-TP53Stephen Lee Abrams, Shaw M. Akula, Alberto Maria Martelli, Lucio Cocco, Stefano Ratti, Massimo Libra, Saverio Candido, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak et al. · 2021 · Advances in Biological Regulation
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- Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cellsMasashi Idogawa, Tomoko Ohashi, Jun Sugisaka, Yasushi Sasaki, Hiromu Suzuki, Takashi Tokino · 2014 · Oncotarget
- Apoptosis in CancerZahid Hussain Siddik · 2014 · Elsevier eBooks
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- What Are the Prospects for Treating TP53 Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia?Chen Wang, David A. Sallman · 2022 · The Cancer Journal
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- Defining key concepts of intestinal and epithelial cancer biology through the use of mouse modelsToby James Phesse, Victoria Marsh Durban, Owen James Sansom · 2017 · Carcinogenesis
- MDM2/P53 Inhibitors as Sensitizing Agents for Cancer ChemotherapyYan Yu Zhu, Herui Wang, Asha Thuraisamy · 2019 · Elsevier eBooks
- PRIMA-1MET Induces Cellular Senescence and Apoptotic Cell Death in Cholangiocarcinoma CellsChayanit Piyawajanusorn, Yingpinyapat Kittirat, Prakasit Sa-Ngiamwibool, Attapol Titapun, Watcharin Loilome, Nisana Namwat · 2019 · Cancer Genomics & Proteomics
- Following in the footsteps of acute myeloid leukemia: are we witnessing the start of a therapeutic revolution for higher-risk myelodysplastic syndromes?Jan Philipp Bewersdorf, Amer Methqal Zeidan · 2020 · Leukemia & lymphoma/Leukemia and lymphoma
- Can the New and Old Drugs Exert an Immunomodulatory Effect in Acute Myeloid Leukemia?Francesco Tarantini, Cosimo Cumbo, Luisa Anelli, Antonella Zagaria, Giorgina Specchia, Pellegrino Musto, Francesco Albano · 2021 · Cancers
- Tumor protein 53 mutations in acute myeloid leukemia: conventional induction chemotherapy or novel therapeuticsHannah H Asghari, Chetasi Talati · 2020 · Current Opinion in Hematology
- Dual-functional copper nanoplatform potentiates cuproptosis through p53 reactivation and metabolic reprogrammingLele Ma, Huiying Zheng, Wanlin Xie, Weidi Sun, Qunying Yuan, Kun Song, Peiyu Xi, Fengli Qu, Hui Zhang · 2025 · Journal of Colloid and Interface Science
- Molecular Features and Treatment Paradigms of Acute Myeloid LeukemiaMihir Shukla, Maher Abdul‐Hay, Jun‐Hui Choi · 2024 · Biomedicines
- SOHO State of the Art and Next Questions: Treatment of Higher-Risk Myelodysplastic SyndromesBrandon J. Aubrey, Andrew Mark Brunner · 2022 · Clinical Lymphoma Myeloma & Leukemia
- Molecular targets for the treatment of AML in the forthcoming 5th World Health Organization Classification of Haematolymphoid TumoursMatteo Molica, Salvatore Perrone · 2022 · Expert Review of Hematology
- Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53Iulianna C. Taritsa, Eric T. Fossel · 2025 · Frontiers in Pharmacology
- Topological properties and in vitro identification of essential nodes of the Paclitaxel and Vincristine interactomes in PC-3 cellsClaudia Delgado-Carreño, Gina Méndez-Callejas · 2019 · Biomedical Journal
- Drugging the Master Regulator TP53 in Cancer: Mission Possible?Giovanni Blandino · 2021 · Journal of Clinical Oncology
- Stability of p53 oligomers: Tetramerization of p53 impinges on its stabilityJohnson Wahengbam Luwang, Aadithye R. Nair, Ramanathan NATESH · 2021 · Biochimie
- What’s New in the Classification, Diagnosis and Therapy of Myeloid LeukemiasMarco Pizzi, Carmela Gurrieri, Attilio Orazi · 2023 · Hemato
- Tumorigenic p53 mutants undergo common structural disruptions including conversion to α‐sheet structureDennis Bromley, Valerie Daggett · 2020 · Protein Science
- Combined treatment with p53-activating drug APR-246 and a phosphatidylserine-targeting antibody, 2aG4, inhibits growth of human triple-negative breast cancer xenograftsYayun Liang, Cynthia L Besch-Williford, Benford Mafuvadze, Rolf A. Brekken, Salman M. Hyder · 2020 · Cancer Reports and Reviews
- Current State and Future Prospects of Diagnosis and Management of TP53-Mutated Myeloid NeoplasmsSangeetha Venugopal, Sanam Loghavi · 2023 · Pathobiology
- What biomarkers (if any) for precise medicine?Sabrina Strano, Paola C. Muti, Giovanni Blandino · 2015 · Aging
- TP53 mutations and MDM2 polymorphisms in breast and ovarian cancers: amelioration by drugs and natural compoundsRituraj Chakraborty, Anupam Dutta, Rupak Mukhopadhyay · 2025 · Clinical & Translational Oncology
- Tumor microenvironment noise-induced polarization: the main challenge in macrophages’ immunotherapy for cancerJesús Sierra, Ugo Avila-Ponce de León, Pablo Padilla-Longoria · 2025 · Molecular and Cellular Biochemistry
- p53-dependent cell cycle checkpoint after DNA damage and its relevance to PARP1Tadashige Nozaki, Mitsuko Masutani · 2018 · Research and Review Insights
- Leveraging innovative therapies with an evolving understanding of the molecular pathogenesis of penile squamous cell carcinomaAli J. Hajiran, Taylor Bracco, Logan W. Zemp, Philippe E. Spiess · 2020 · Urologic Oncology Seminars and Original Investigations
- Molecular and therapeutic bases of cancerGuadalupe Rosario Fajardo-Orduña, D. Chamorro-Plata · 2021 · Elsevier eBooks
- Differential roles of the Wip1–p38–p53 DNA damage response pathway in early/advanced-stage ovarian clear cell carcinomasChenyang Xu, Takeo Minaguchi, Nan Qi, Kaoru Fujieda, Asami Suto, Hiroya Itagaki, Ayumi Shikama, Nobutaka Tasaka, Azusa Akiyama, Sari Nakao et al. · 2022 · World Journal of Surgical Oncology
- Targeting Mutated p53: Naivete and Enthusiasm to Attempt the ImpossibleWafik S. El‐Deiry · 2023 · Cancer Research
- Novel Approaches and Future Directions in Myelodysplastic Syndrome TreatmentJan Philipp Bewersdorf, Zhuoer Xie, Amer Methqal Zeidan · 2023 · The Cancer Journal
- A step closer toward therapies for p63-related disordersHuiqing Zhou, Daniel Aberdam · 2013 · Rare Diseases
- Breast Cancer Therapy by Small-Molecule Reactivation of Mutant p53Simon H. Slight, Salman M. Hyder · 2025 · Current Oncology
- Modulation of Apoptosis Pathways in the Biology and Treatment of Multiple MyelomaRadhika Bansal, Sagar Rakshit, Weiguo Han, Shaji Kunnathu Kumar · 2021 · touchREVIEWS in Oncology & Haematology
- Appendiceal Goblet Cell Carcinoma: Role of Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)Marie Gaillard, Peter Van Eyken, Geert Verswijvel, Kurt Van der Speeten · 2023 · Indian Journal of Surgical Oncology
- TP53 structure–function relationships in metastatic castrate‐sensitive prostate cancer and the impact of APR‐246 treatmentTung Hoang, Philip Anthony Sutera, Triet Nguyen, Jinhee Chang, Shreya Jagtap, Yang Song, Amol Carl Shetty, Dipanwita D. Chowdhury, Aaron Chan, Francesca A. Carrieri et al. · 2023 · The Prostate
- Advances in the management of higher-risk myelodysplastic syndromes: future prospectsGeorgina Gener‐Ricos, Juan José Rodríguez‐Sevilla, Samuel Urrutia, Álex Bataller, Alexandre Bazinet, Guillermo Garcia‐Manero · 2024 · Leukemia & lymphoma/Leukemia and lymphoma
- A review of first-in-human small molecule oncology clinical trialsDaniel Greenwood, Ian James Stratford, Steven W. Booth · 2016 · International Journal of Clinical Trials
- Precision Medicine Based on Next-Generation Sequencing and Master ControllersKaterina Dukleska, Charles J. Yeo, Michael Jon Pishvaian, Jonathan Robert Brody · 2018 · Springer eBooks
- The Cell Cycle and Androgen Signaling Interactions in Prostate CancerSimone de Brot, Nigel Patrick Mongan · 2017 · Molecular pathology library
- Caractérisation génomique des carcinomes épidermoïdes de la tête et du cou : impact et enjeux pour la prise en charge thérapeutiqueEsma Saâda-Bouzid, Gerard Alain Milano, Juliette Thariat · 2018 · Bulletin du Cancer
- Targeting TP53 Mutations in Myelodysplastic SyndromesDavid Andrew Sallman · 2018 · The Hematologist
- Treatment Strategy for Ultra-High-Risk Multiple Myelomas with Chromosomal Aberrations Considering Minimal Residual Disease Status and Bone Marrow MicroenvironmentKazuhito Suzuki, Shingo Yano · 2023 · Cancers
- Precision medicine for TP53-mutated acute myeloid leukemiaMarte Karen Brattås, Håkon Reikvam, Tor Henrik Anderson Tvedt, Øystein Bruserud · 2019 · Expert Review of Precision Medicine and Drug Development
- Az akut mieloid leukémia kezelésének új lehetőségei: út a személyre szabott terápiás stratégiák feléZsolt Szakács, Hussain Alizadeh · 2022 · Hematológia–Transzfuziológia
- Structural and functional studies of proteins in cell signaling and cancerRebecca Dovega · 2014 · Figshare
- p53 mutation-associated prognosis across cancer types underlines hematological malignancy as an applicable cancer type to p53-rescue therapyShujun Xiao, Jiaqi Wu, Kai Wei Tan, Sujiang Zhang, Yuting Dai, Jiarui Wu, Jiale Wu, Xinle Han, Derun Zheng, Xin Wang et al. · 2025 · Fundamental Research
- Pharmacologic progress in higher-risk MDS: an uphill battleAlain Antoine Mina, Amer Methqal Zeidan · 2026 · Expert Opinion on Pharmacotherapy
- Reactivating p53 mutants selectively in patientsShuo Chen, H. Michael Shepard, Min Lu · 2026 · Cancer Cell
- Wild-Type p53 Protein Enhances APR-246-Induced Cytotoxicity in Acute Myeloid Leukemia and Normal Hematopoietic Stem/Progenitor CellsJohn Bradley Cart, David Zhu, Lucas Norris, Sadhna O. Piryani, Li-Chan Chang, Christine Elissa Eyler, Chang‐Lung Lee · 2026 · International Journal of Molecular Sciences
- Drugging p53 mutants: Recent advances using small-molecule modulation strategiesElizabeth A. Lopes, Tomás G. Monteiro, Maria M. M. Santos · 2026 · European Journal of Medicinal Chemistry
- Targeting apoptosis is the major battle field for killing cancersXiaochun Liu · 2015 · World Journal of Translational Medicine
- Small molecules targeting misfolded mutants of p53 as a rescue strategy to improve glioblastoma chemotherapyArutselvan Natarajan, Husam A. Babikir, Ramasamy Paulmurugan, Tarik F. Massoud · 2021 · Elsevier eBooks
- Research Progress of Mutant p53 as a Potential Therapeutic Target for Breast Cancer俊臻 周 · 2021 · Advances in Clinical Medicine
- Prognostic significance of tumor suppressor protein p53 in prostate cancerSarra Ben Rejeb, Nadia Kouki, Sirine Elfekih, Ines Cherif, Hassen Khouni · 2024 · La Tunisie Médicale
- Abstract CT204: Preliminary results from PiSARRO, a phase Ib/II study of APR-246, a mutant p53 reactivating small molecule, in combination with standard chemotherapy in platinum-sensitive ovarian cancerMikael von Euler, Klas G. Wiman, Hani Gabra, James D. Brenton, Bristi Basu, Ignace B. Vergote, Charlie Gourley, Austin Smith, Jessica Alfredsson, Nina Mohell et al. · 2015 · Cancer Research
- Studies of New Signal Transduction Modulators in Acute Myeloid LeukemiaAnna Eriksson · 2012 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
- TP53 mutations in myelodysplastic syndromes with deletion of 5qLeonie Saft · 2013 · Figshare
- Molecular genetic studies on Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia - with focus on prognostic markersKerstin Willander · 2014 · Linköping University Electronic Press eBooks
- 4th international conference on tumor progression and therapeutic resistance: meeting reportVarun V. Prabhu, Wafik S. El‐Deiry · 2015 · Cancer Biology & Therapy
- Mechanisms of p53-mediated intrinsic and extrinsic tumor suppressionHai Li · 2014 · Figshare
- How far is the horizon? From current targets to future drugs in advanced renal cancerStephan Kruck, Axel S. Merseburger, Arnulf Stenzl, Jens Bedke · 2013 · World Journal of Urology
- Mutacje TP53 w nowotworach hematologicznychM Zajac, Krzysztof Giannopoulos · 2015 · Acta Haematologica Polonica
- Mechanisms of p53-mediated Intrinsic and Extrinsic Tumor SuppressionGalina Selivanova, Petter Höglund, Giulia Piaggio, Regina Elena, Teresa Pereira, Anthony R. Wright, Claes Wadelius, Uppusala Universitit · 2014
- Review Article A review of first-in-human small molecule oncology clinical trialsDaniel J.H. Greenwood, Ian James Stratford, Steven W. Booth · 2016
- Investigation of novel therapeutic strategies for epithelial ovarian cancerNobuhisa Yoshikawa · 2016 · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
- Visual Analytics Methods for Analyzing Molecular Dynamics Simulations of Mutant ProteinsDennis Bromley · 2015 · ResearchWorks at the University of Washington (University of Washington)
- Characterization and functional analysis of mutant p53 secretome in human cancerReshma Shakya · 2016 · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
- Understanding p53 structure and targeting mutant p53 for improved cancer therapyQiang Zhang · 2018 · Figshare
- Making sense from nonsense and missense : pharmacological rescue of mutant tumor suppressor p53Meiqiongzi Zhang · 2018 · Figshare
- Molecular targets and targeted therapyPeixin Dong · 2014
- Targeted Next-Generation Sequencing in Head and Neck CancerIngeborg Tinhofer · 2018 · Springer eBooks
- Discovery Of Piperlongumine Derivatives As Anti-Leukemic And Anti-Prostate Cancer AgentsYi Liao · 2018 · Human Biology
- Transplantation for TP53 mutant MDS: Room for improvementDries Deeren · 2018 · Leukemia Research
- As vias de p53/ARF e interferon beta como alvos de terapia gênica de carcinoma colorretalPaulo Roberto Del Valle · 2019
- Change in mutation frequency at a TP53 hotspot during culture of ENU-mutagenised human lymphoblastoid cellsMasahiko Watanabe, Masae Toudou, Taeko Uchida, Misato Yoshikawa, Hiroaki Aso, Katsuya Suemaru · 2019 · Mutagenesis
- OVER KANSERİ HÜCRELERİNDE PRİMA-1 Met TEDAVİSİNE YANIT OLARAK DEĞİŞEN miRNA EKSPRESYON ANALİZİNilüfer İmir, Esra Arslan Aydemir, Ece Şimşek · 2020 · Sağlık Bilimleri Dergisi
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- Mechanisms of Resistence of New Target Drugs in Acute Myeloid LeukemiaDebora Capelli, Francesco Saraceni, Diego Menotti, Alessandro Fiorentini, Attilio Olivieri · 2020 · IntechOpen eBooks
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- Updates on Acute Myeloid Leukemia Management in older patientsSalman Otoukesh, Julio Alvarenga Thiebaud, Guido Marcucci, Monzr M. Al Malki · 2021 · Trends in Transplantation
- Three essays on licensing university inventionsRadu Munteanu · 2007 · eScholarship (California Digital Library)
- Targeting MDM2, the antagonist of the tumor suppressor p53Anusha Sriraman · 2018 · eDiss (Georg-August-Universität Göttingen)
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- TP53Kensuke Kojima, Michael Andreeff · 2015 · Wiley eBooks
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- RAD54L Is a Prognostic Biomarker and Demonstrate Correlation With Drug Sensitivity in Hepatocellular CarcinomaTingting You, Hui Jun Tang, Hui Ge, Chunmei Bai, Jianfeng Zhou · 2025 · Cell Biology International
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