Wiman, Klas G.

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

Bykov, V. J. N., Issaeva, N., Shilov, A., Hultcrantz, M., Pugacheva, E., Chumakov, P., Bergman, J., Wiman, K. G., & Selivanova, G. (2002) · Nature Medicine

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 1,067

Targeting mutant p53 for efficient cancer therapy

Bykov, V. J. N., Eriksson, S. E., Bianchi, J., & Wiman, K. G. (2018) · Nature Reviews Cancer

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 889

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

Lambert, J. M. R., Gorzov, P., Veprintsev, D. B., Söderqvist, M., Segerbäck, D., Bergman, J., Fersht, A. R., Hainaut, P., Wiman, K. G., & Bykov, V. J. N. (2009) · Cancer Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 592

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

Lehmann, S., Bykov, V. J. N., Ali, D., Andrén, O., Cherif, H., Tidefelt, U., Uggla, B., Yachnin, J., Juliusson, G., Moshfegh, A., et al. (2012) · Journal of Clinical Oncology

Cancer-related Molecular PathwaysAcute Myeloid Leukemia Research

Cited by 406

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Liu, D. S., Duong, C. P., Haupt, S., Montgomery, K. G., House, C. M., Azar, W. J., Pearson, H. B., Fisher, O. M., Read, M., Guerra, G. R., et al. (2017) · Nature Communications

Cancer-related Molecular PathwaysSulfur Compounds in Biology

Cited by 321

TP53: an oncogene in disguise

Soussi, T., & Wiman, K. G. (2015) · Cell Death & Differentiation

Cancer-related Molecular PathwaysChromatin Remodeling and Cancer

Cited by 305

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Zhang, Q., Bykov, V. J. N., Wiman, K. G., & Zawacka-Pankau, J. (2018) · Cell Death & Disease

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 261

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

Xu, D., Wang, Q., Gruber, A., Björkholm, M., Chen, Z., Zaid, A., Selivanova, G., Peterson, C., Wiman, K. G., & Pisa, P. (2000) · Oncogene

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 257

PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis

Bykov, V. J. N., Zache, N., Stridh, H., Westman, J., Bergman, J., Selivanova, G., & Wiman, K. G. (2005) · Oncogene

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 252

Reactivation of mutant p53: molecular mechanisms and therapeutic potential

Selivanova, G., & Wiman, K. G. (2007) · Oncogene

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 186

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

Mohell, N., Alfredsson, J., Fransson, Å., Uustalu, M., Byström, S., Gullbo, J., Hallberg, A., Bykov, V. J. N., Björklund, U., & Wiman, K. G. (2015) · Cell Death & Disease

Cancer-related Molecular PathwaysOvarian cancer diagnosis and treatment

Cited by 183

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

Peng, X., Zhang, M.-Q.-Z., Conserva, F., Hosny, G., Selivanova, G., Bykov, V. J. N., Arnér, E. S. J., & Wiman, K. G. (2013) · Cell Death & Disease

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 170

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Bykov, V. J. N., Zhang, Q., Zhang, M., Ceder, S., Abrahmsen, L., & Wiman, K. G. (2016) · Frontiers in Oncology

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 137

p53 as a hub in cellular redox regulation and therapeutic target in cancer

Eriksson, S. E., Ceder, S., Bykov, V. J. N., & Wiman, K. G. (2019) · Journal of Molecular Cell Biology

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 123

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Haffo, L., Lu, J., Bykov, V. J. N., Martin, S. S., Ren, X., Coppo, L., Wiman, K. G., & Holmgren, A. (2018) · Scientific Reports

Redox biology and oxidative stressCancer-related Molecular Pathways

Cited by 73

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant high-grade serous ovarian cancer

Fransson, Å., Glaessgen, D., Alfredsson, J., Wiman, K. G., Bajalica-Lagercrantz, S., & Mohell, N. (2016) · Journal of Ovarian Research

Ovarian cancer diagnosis and treatmentCancer-related Molecular Pathways

Cited by 65

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

Ceder, S., Eriksson, S. E., Cheteh, E. H., Dawar, S., Corrales Benitez, M., Bykov, V. J. N., Fujihara, K. M., Grandin, M., Li, X., Ramm, S., et al. (2021) · EMBO Molecular Medicine

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 41

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

Synnott, N. C., Madden, S. F., Bykov, V. J. N., Crown, J., Wiman, K. G., & Duffy, M. J. (2018) · Translational Oncology

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 35

Mutant p53 protein, master regulator of human malignancies: A report on the Fifth Mutant p53 Workshop

Blandino, G., Deppert, W., Hainaut, P., Levine, A., Lozano, G., Olivier, M., Rotter, V, Wiman, K., & Oren, M. (2012) · Cell Death & Differentiation

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 34

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Ceder, S., Eriksson, S. E., Liang, Y. Y., Cheteh, E. H., Zhang, S. M., Fujihara, K. M., Bianchi, J., Bykov, V. J. N., Abrahmsen, L., Clemons, N. J., et al. (2021) · Cell Death & Disease

Acute Lymphoblastic Leukemia researchCancer-related Molecular Pathways

Cited by 18