The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951
Open accessAbstract
Purpose: Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present the long-term follow-up findings of a randomized phase III study on the addition of six cycles of procarbazine, lomustine, and vincristine (PCV) chemotherapy to radiotherapy (RT). Patients and Methods: Adult patients with newly diagnosed anaplastic oligodendroglial tumors were randomly assigned to either 59.4 Gy of RT or the same RT followed by six cycles of adjuvant PCV. An exploratory analysis of the correlation between 1p/19q status and survival was part of the study. Retrospectively, the methylation status of the methyl-guanine methyl transferase gene promoter and the mutational status of the isocitrate dehydrogenase (IDH) gene were determined. The primary end points were overall survival (OS) and progression-free survival based on intent-to-treat analysis. Results: A total of 368 patients were enrolled. With a median follow-up of 140 months, OS in the RT/PCV arm was significantly longer (42.3 v 30.6 months in the RT arm, hazard ratio [HR], 0.75; 95% CI, 0.60 to 0.95). In the 80 patients with a 1p/19q codeletion, OS was increased, with a trend toward more benefit from adjuvant PCV (OS not reached in the RT/PCV group v 112 months in the RT group; HR, 0.56; 95% CI, 0.31 to 1.03). IDH mutational status was also of prognostic significance. Conclusion: The addition of six cycles of PCV after 59.4 Gy of RT increases both OS and PFS in anaplastic oligodendroglial tumors. 1p/19q-codeleted tumors derive more benefit from adjuvant PCV compared with non–1p/19q-deleted tumors.
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An Integrated Genomic Analysis of Human Glioblastoma Multiforme
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Cited by
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
The Cancer Genome Atlas Research Network (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402121 · Cited by 3,148
EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood
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Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
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Glioma Subclassifications and Their Clinical Significance
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Metadata
- Authors
- van den Bent, M. J., Brandes, A. A., Taphoorn, M. J. B., Kros, J. M., Kouwenhoven, M. C. M., Delattre, J.-Y., Bernsen, H. J. J. A., Frenay, M., Tijssen, C. C., Grisold, W., Sipos, L., Enting, R. H., French, P. J., Dinjens, W. N. M., Vecht, C. J., Allgeier, A., Lacombe, D., Gorlia, T., & Hoang-Xuan, K.
- Venue
- Journal of Clinical Oncology
- Published
- 2013-01-20
- Volume
- 31
- Issue
- 3
- Pages
- 344-350
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2133865472
- Cited by
- 1,226
- References
- 7
- FWCI
- 37.89
- Type
- journal article
- Language
- en
- Open access
- green
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- van den Bent, M. J., Brandes, A. A., Taphoorn, M. J. B., Kros, J. M., Kouwenhoven, M. C. M., Delattre, J.-Y., Bernsen, H. J. J. A., Frenay, M., Tijssen, C. C., Grisold, W., Sipos, L., Enting, R. H., French, P. J., Dinjens, W. N. M., Vecht, C. J., Allgeier, A., Lacombe, D., Gorlia, T., & Hoang-Xuan, K. (2013). Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2012.43.2229
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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