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The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Type I and II Endometrial Cancers: Have They Different Risk Factors?

Open access
Setiawan, Veronica Wendy, Yang, Hannah P., Pike, Malcolm C., McCann, Susan E., Yu, Herbert, Xiang, Yong-Bing, Wolk, Alicja, Wentzensen, Nicolas, Weiss, Noel S., Webb, Penelope M., van den Brandt, Piet A., van de Vijver, Koen, Thompson, Pamela J., The Australian National Endometrial Cancer Study Group, Strom, Brian L., Spurdle, Amanda B., Soslow, Robert A., Shu, Xiao-ou, Schairer, Catherine, Sacerdote, Carlotta, Rohan, Thomas E., Robien, Kim, Risch, Harvey A., Ricceri, Fulvio, Rebbeck, Timothy R., Rastogi, Radhai, Prescott, Jennifer, Polidoro, Silvia, Park, Yikyung, Olson, Sara H., Moysich, Kirsten B., Miller, Anthony B., McCullough, Marjorie L., Matsuno, Rayna K., Magliocco, Anthony M., Lurie, Galina, Lu, Lingeng, Lissowska, Jolanta, Liang, Xiaolin, Lacey, James V., Kolonel, Laurence N., Henderson, Brian E., Hankinson, Susan E., Håkansson, Niclas, Goodman, Marc T., Gaudet, Mia M., Garcia-Closas, Montserrat, Friedenreich, Christine M., Freudenheim, Jo L., Doherty, Jennifer, De Vivo, Immaculata, Courneya, Kerry S., Cook, Linda S., Chen, Chu, Cerhan, James R., Cai, Hui, Brinton, Louise A., Bernstein, Leslie, Anderson, Kristin E., Anton-Culver, Hoda, Schouten, Leo J., Horn-Ross, Pamela L.·2013·Journal of Clinical Oncology
DOI 10.1200/jco.2012.48.2596
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Abstract

Purpose: Endometrial cancers have long been divided into estrogen-dependent type I and the less common clinically aggressive estrogen-independent type II. Little is known about risk factors for type II tumors because most studies lack sufficient cases to study these much less common tumors separately. We examined whether so-called classical endometrial cancer risk factors also influence the risk of type II tumors. Patients and Methods: Individual-level data from 10 cohort and 14 case-control studies from the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 14,069 endometrial cancer cases and 35,312 controls were included. We classified endometrioid (n = 7,246), adenocarcinoma not otherwise specified (n = 4,830), and adenocarcinoma with squamous differentiation (n = 777) as type I tumors and serous (n = 508) and mixed cell (n = 346) as type II tumors. Results: Parity, oral contraceptive use, cigarette smoking, age at menarche, and diabetes were associated with type I and type II tumors to similar extents. Body mass index, however, had a greater effect on type I tumors than on type II tumors: odds ratio (OR) per 2 kg/m 2 increase was 1.20 (95% CI, 1.19 to 1.21) for type I and 1.12 (95% CI, 1.09 to 1.14) for type II tumors (P heterogeneity < .0001). Risk factor patterns for high-grade endometrioid tumors and type II tumors were similar. Conclusion: The results of this pooled analysis suggest that the two endometrial cancer types share many common etiologic factors. The etiology of type II tumors may, therefore, not be completely estrogen independent, as previously believed.

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  1. 10.1097/GRF.0b013e318218c755 · doi:10.1097/grf.0b013e318218c755
  2. Sherman ME, 1997, Mod Pathol, 10, 963
  3. 10.1097/PAS.0b013e318247b7bb · doi:10.1097/pas.0b013e318247b7bb
  4. Kaaks R, 2002, Cancer Epidemiol Biomarkers Prev, 11, 1531

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Metadata

Authors
Setiawan, V. W., Yang, H. P., Pike, M. C., McCann, S. E., Yu, H., Xiang, Y.-B., Wolk, A., Wentzensen, N., Weiss, N. S., Webb, P. M., van den Brandt, P. A., van de Vijver, K., Thompson, P. J., The Australian National Endometrial Cancer Study Group, Strom, B. L., Spurdle, A. B., Soslow, R. A., Shu, X.-O., Schairer, C., Sacerdote, C., Rohan, T. E., Robien, K., Risch, H. A., Ricceri, F., Rebbeck, T. R., Rastogi, R., Prescott, J., Polidoro, S., Park, Y., Olson, S. H., Moysich, K. B., Miller, A. B., McCullough, M. L., Matsuno, R. K., Magliocco, A. M., Lurie, G., Lu, L., Lissowska, J., Liang, X., Lacey, J. V., Kolonel, L. N., Henderson, B. E., Hankinson, S. E., Håkansson, N., Goodman, M. T., Gaudet, M. M., Garcia-Closas, M., Friedenreich, C. M., Freudenheim, J. L., Doherty, J., De Vivo, I., Courneya, K. S., Cook, L. S., Chen, C., Cerhan, J. R., Cai, H., Brinton, L. A., Bernstein, L., Anderson, K. E., Anton-Culver, H., Schouten, L. J., & Horn-Ross, P. L.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2013-07-10
Volume
31
Issue
20
Pages
2607-2618
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2012.48.2596
OpenAlex
W2109870736
Cited by
827
References
28
FWCI
54.35
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Type I and II Endometrial Cancers: Have They Different Risk Factors? https://app.cochat.ai/papers/10.1200/jco.2012.48.2596
The paper
Setiawan, V. W., Yang, H. P., Pike, M. C., McCann, S. E., Yu, H., Xiang, Y.-B., Wolk, A., Wentzensen, N., Weiss, N. S., Webb, P. M., van den Brandt, P. A., van de Vijver, K., Thompson, P. J., The Australian National Endometrial Cancer Study Group, Strom, B. L., Spurdle, A. B., Soslow, R. A., Shu, X.-O., Schairer, C., . . . Horn-Ross, P. L. (2013). Type I and II Endometrial Cancers: Have They Different Risk Factors? Journal of Clinical Oncology. https://doi.org/10.1200/jco.2012.48.2596

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.