The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Interim Cosmetic and Toxicity Results From RAPID: A Randomized Trial of Accelerated Partial Breast Irradiation Using Three-Dimensional Conformal External Beam Radiation Therapy
Open accessAbstract
Purpose: To report interim cosmetic and toxicity results of a multicenter randomized trial comparing accelerated partial-breast irradiation (APBI) using three-dimensional conformal external beam radiation therapy (3D-CRT) with whole-breast irradiation (WBI). Patients and Methods: Women age > 40 years with invasive or in situ breast cancer ≤ 3 cm were randomly assigned after breast-conserving surgery to 3D-CRT APBI (38.5 Gy in 10 fractions twice daily) or WBI (42.5 Gy in 16 or 50 Gy in 25 daily fractions ± boost irradiation). The primary outcome was ipsilateral breast tumor recurrence (IBTR). Secondary outcomes were cosmesis and toxicity. Adverse cosmesis was defined as a fair or poor global cosmetic score. After a planned interim cosmetic analysis, the data, safety, and monitoring committee recommended release of results. There have been too few IBTR events to trigger an efficacy analysis. Results: Between 2006 and 2011, 2,135 women were randomly assigned to 3D-CRT APBI or WBI. Median follow-up was 36 months. Adverse cosmesis at 3 years was increased among those treated with APBI compared with WBI as assessed by trained nurses (29% v 17%; P < .001), by patients (26% v 18%; P = .0022), and by physicians reviewing digital photographs (35% v 17%; P < .001). Grade 3 toxicities were rare in both treatment arms (1.4% v 0%), but grade 1 and 2 toxicities were increased among those who received APBI compared with WBI (P < .001). Conclusion: 3D-CRT APBI increased rates of adverse cosmesis and late radiation toxicity compared with standard WBI. Clinicians and patients are cautioned against the use of 3D-CRT APBI outside the context of a controlled trial.
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Long-Term Results of Hypofractionated Radiation Therapy for Breast Cancer
Whelan, T. J., Pignol, J.-P., Levine, M. N., Julian, J. A., MacKenzie, R., Parpia, S., Shelley, W., Grimard, L., Bowen, J., Lukka, H., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0906260 · Cited by 1,878
Self-citation(2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70077-9 · Cited by 1,132
Bartelink, H., Horiot, J.-C., Poortmans, P. M., Struikmans, H., Van den Bogaert, W., Fourquet, A., Jager, J. J., Hoogenraad, W. J., Oei, S. B., Wárlám-Rodenhuis, C. C., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.4991 · Cited by 1,047
Smith, B. D., Arthur, D. W., Buchholz, T. A., Haffty, B. G., Hahn, C. A., Hardenbergh, P. H., Julian, T. B., Marks, L. B., Todor, D. A., Vicini, F. A., et al. (2009) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.02.031 · Cited by 872
Self-citationVaidya, J. S., Joseph, D. J., Tobias, J. S., Bulsara, M., Wenz, F., Saunders, C., Alvarado, M., Flyger, H. L., Massarut, S., Eiermann, W., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60837-9 · Cited by 772
Polgár, C., Limbergen, E. V., Pötter, R., Kovács, G., Polo, A., Lyczek, J., Hildebrandt, G., Niehoff, P., Guinot, J. L., Guedea, F., et al. (2010) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2010.01.014 · Cited by 633
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Accelerated partial breast irradiation using 3D conformal radiation therapy (3D-CRT)
Baglan, K. L., Sharpe, M. B., Jaffray, D., Frazier, R. C., Fayad, J., Kestin, L. L., Remouchamps, V., Martinez, A. A., Wong, J., & Vicini, F. A. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)03811-7 · Cited by 289
Cited by
Strnad, V., Ott, O. J., Hildebrandt, G., Kauer-Dorner, D., Knauerhase, H., Major, T., Lyczek, J., Guinot, J. L., Dunst, J., Miguelez, C. G., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00471-7 · Cited by 659
Polgár, C., Ott, O. J., Hildebrandt, G., Kauer-Dorner, D., Knauerhase, H., Major, T., Lyczek, J., Guinot, J. L., Dunst, J., Miguelez, C. G., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30011-6 · Cited by 257
Prevalence of pain in patients with breast cancer post-treatment: A systematic review
Wang, K., Yee, C., Tam, S., Drost, L., Chan, S., Zaki, P., Rico, V., Ariello, K., Dasios, M., Lam, H., et al. (2018) · The Breast · doi:10.1016/j.breast.2018.08.105 · Cited by 176
Metadata
- Authors
- Olivotto, I. A., Whelan, T. J., Parpia, S., Kim, D.-H., Berrang, T., Truong, P. T., Kong, I., Cochrane, B., Nichol, A., Roy, I., Germain, I., Akra, M., Reed, M., Fyles, A., Trotter, T., Perera, F., Beckham, W., Levine, M. N., & Julian, J. A.
- Venue
- Journal of Clinical Oncology
- Published
- 2013-11-10
- Volume
- 31
- Issue
- 32
- Pages
- 4038-4045
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2115718867
- Cited by
- 379
- References
- 22
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Olivotto, I. A., Whelan, T. J., Parpia, S., Kim, D.-H., Berrang, T., Truong, P. T., Kong, I., Cochrane, B., Nichol, A., Roy, I., Germain, I., Akra, M., Reed, M., Fyles, A., Trotter, T., Perera, F., Beckham, W., Levine, M. N., & Julian, J. A. (2013). Interim Cosmetic and Toxicity Results From RAPID: A Randomized Trial of Accelerated Partial Breast Irradiation Using Three-Dimensional Conformal External Beam Radiation Therapy. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2013.50.5511
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
