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Cited by 362

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients With Relapsed Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma

Ogura, Michinori, Ishida, Takashi, Hatake, Kiyohiko, Taniwaki, Masafumi, Ando, Kiyoshi, Tobinai, Kensei, Fujimoto, Katsuya, Yamamoto, Kazuhito, Miyamoto, Toshihiro, Uike, Naokuni, Tanimoto, Mitsune, Tsukasaki, Kunihiro, Ishizawa, Kenichi, Suzumiya, Junji, Inagaki, Hiroshi, Tamura, Kazuo, Akinaga, Shiro, Tomonaga, Masao, Ueda, Ryuzo·2014·Journal of Clinical Oncology
DOI 10.1200/jco.2013.52.0924
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Abstract

Purpose: CC chemokine receptor 4 (CCR4) is expressed by peripheral T-cell lymphomas (PTCLs) and is associated with poor outcomes. Mogamulizumab (KW-0761) is a defucosylated humanized anti-CCR4 antibody engineered to exert potent antibody-dependent cellular cytotoxicity. This multicenter phase II study evaluated the efficacy and safety of mogamulizumab in patients with relapsed PTCL and cutaneous T-cell lymphoma (CTCL). Patients and Methods: Mogamulizumab (1.0 mg/kg) was administered intravenously once per week for 8 weeks to patients with relapsed CCR4-positive PTCL or CTCL. The primary end point was the overall response rate, and the secondary end points included safety, progression-free survival (PFS), and overall survival (OS). Results: A total of 38 patients were enrolled, and 37 patients received mogamulizumab. Objective responses were noted for 13 of 37 patients (35%; 95% CI, 20% to 53%), including five patients (14%) with complete response. The median PFS was 3.0 months (95% CI, 1.6 to 4.9 months), and the median OS was not calculated. The mean maximum and trough mogamulizumab concentrations (± standard deviation) after the eighth infusion were 45.9 ± 9.3 and 29.0 ± 13.3 μg/mL, respectively. The most common adverse events were hematologic events, pyrexia, and skin disorders, all of which were reversible and manageable. Conclusion: Mogamulizumab exhibited clinically meaningful antitumor activity in patients with relapsed PTCL and CTCL, with an acceptable toxicity profile. Further investigation of mogamulizumab for treatment of T-cell lymphoma is warranted.

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Metadata

Authors
Ogura, M., Ishida, T., Hatake, K., Taniwaki, M., Ando, K., Tobinai, K., Fujimoto, K., Yamamoto, K., Miyamoto, T., Uike, N., Tanimoto, M., Tsukasaki, K., Ishizawa, K., Suzumiya, J., Inagaki, H., Tamura, K., Akinaga, S., Tomonaga, M., & Ueda, R.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2014-04-10
Volume
32
Issue
11
Pages
1157-1163
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2013.52.0924
OpenAlex
W2057910076
Cited by
362
References
37
FWCI
42.12
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients With Relapsed Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma. https://app.cochat.ai/papers/10.1200/jco.2013.52.0924
The paper
Ogura, M., Ishida, T., Hatake, K., Taniwaki, M., Ando, K., Tobinai, K., Fujimoto, K., Yamamoto, K., Miyamoto, T., Uike, N., Tanimoto, M., Tsukasaki, K., Ishizawa, K., Suzumiya, J., Inagaki, H., Tamura, K., Akinaga, S., Tomonaga, M., & Ueda, R. (2014). Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients With Relapsed Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2013.52.0924

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.